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The cholesterol uptake regulator PCSK9 promotes and is a therapeutic target in APC/KRAS-mutant colorectal cancer
Therapeutic targeting of KRAS -mutant colorectal cancer (CRC) is an unmet need. Here, we show that Proprotein Convertase Subtilisin/Kexin type 9...
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SOAT1 regulates cholesterol metabolism to induce EMT in hepatocellular carcinoma
Cholesterol metabolism reprogramming is one of the significant characteristics of hepatocellular carcinoma (HCC). Cholesterol increases the risk of...
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DHCR24 reverses Alzheimer’s disease-related pathology and cognitive impairment via increasing hippocampal cholesterol levels in 5xFAD mice
Accumulating evidences reveal that cellular cholesterol deficiency could trigger the onset of Alzheimer’s disease (AD). As a key regulator,...
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Metformin Inhibits Zika Virus Infection in Trophoblast Cell Line
Zika virus (ZIKV) infections have been associated with severe clinical outcomes, which may include neurological manifestations, especially in...
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TDP-43 regulates cholesterol biosynthesis by inhibiting sterol regulatory element-binding protein 2
Dyslipidemia is considered an essential component of the pathological process of amyotrophic lateral sclerosis (ALS), a fatal motor neuron disease....
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TNFAIP1 promotes macrophage lipid accumulation and accelerates the development of atherosclerosis through the LEENE/FoxO1/ABCA1 pathway
Macrophage lipid accumulation is a critical contributor to foam cell formation and atherosclerosis. Tumor necrosis factor-α-induced protein 1...
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LIMA1 links the E3 ubiquitin ligase RNF40 to lipid metabolism
LIMA1 is a LIM domain and Actin binding 1 protein that acts as a skeleton protein to promote cholesterol absorption, which makes it an ideal target...
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Sodium butyrate alleviates deoxynivalenol-induced hepatic cholesterol metabolic dysfunction via RORγ-mediated histone acetylation modification in weaning piglets
BackgroundCholesterol is an essential component of lipid rafts in cell plasma membrane, which exerts a hepatoprotective role against mycotoxin...
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MBTPS2 acts as a regulator of lipogenesis and cholesterol synthesis through SREBP signalling in prostate cancer
BackgroundProstate cancer is the most common cancer in men in the developed world, with most deaths caused by advanced and metastatic disease which...
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Retinoic acid increases the cellular cholesterol predominantly in a mTOR-independent manner
Retinoic acid (RA) plays a role in the mounting immune response and controls several functions of the human body, including cholesterol homeostasis....
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Oncheong-eum alleviated hepatic lipid accumulation and intestinal barrier disruption in nonalcoholic steatohepatitis in vivo model
BackgroundObesity refers to a range of disorders associated with fatty liver, which occur in abnormal and accumulated excessive fat as well as...
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USP28 controls SREBP2 and the mevalonate pathway to drive tumour growth in squamous cancer
SREBP2 is a master regulator of the mevalonate pathway (MVP), a biosynthetic process that drives the synthesis of dolichol, heme A, ubiquinone and...
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Biological functions of CRTC2 and its role in metabolism-related diseases
CREB-regulated transcription coactivator2 (CRTC2 or TORC2) is a transcriptional coactivator of CREB(cAMP response element binding protein), which...
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TFEB controls integrin-mediated endothelial cell adhesion by the regulation of cholesterol metabolism
The dynamic integrin-mediated adhesion of endothelial cells (ECs) to the surrounding ECM is fundamental for angiogenesis both in physiological and...
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SIK2 enhances synthesis of fatty acid and cholesterol in ovarian cancer cells and tumor growth through PI3K/Akt signaling pathway
Salt-inducible kinase 2 (SIK2) has been established as a regulator of diverse biological processes including cell metabolism. A recent study has...
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Deubiquitinase USP35 stabilizes BRPF1 to activate mevalonate (MVA) metabolism during prostate tumorigenesis
The mutual interplay between epigenetic modifications and metabolic rewiring contributes to malignant features of prostate adenocarcinoma (PRAD)....
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Hepatic SREBP signaling requires SPRING to govern systemic lipid metabolism in mice and humans
The sterol regulatory element binding proteins (SREBPs) are transcription factors that govern cholesterol and fatty acid metabolism. We recently...
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The translational potential of cholesterol-based therapies for neurological disease
Cholesterol is an important metabolite and membrane component and is enriched in the brain owing to its role in neuronal maturation and function. In...
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The roles of different microRNAs in the regulation of cholesterol in viral hepatitis
Cholesterol plays a significant role in stabilizing lipid or membrane rafts, which are specific cellular membrane structures. Cholesterol is involved...
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Adaptive activation of EFNB2/EPHB4 axis promotes post-metastatic growth of colorectal cancer liver metastases by LDLR-mediated cholesterol uptake
The microenvironment of distant organ plays vital roles in regulating tumor metastases. However, little is known about the crosstalk between...
