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Immunologic and Genetic Contributors to CD46-Dependent Immune Dysregulation
Mutations in CD46 predispose to atypical hemolytic uremic syndrome (aHUS) with low penetrance. Factors driving immune-dysregulatory disease in...
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B cells in multiple sclerosis — from targeted depletion to immune reconstitution therapies
Increasing evidence indicates the involvement of B cells in the pathogenesis of multiple sclerosis (MS), but their precise roles are unclear. In this...
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Single-cell sequencing resolves the landscape of immune cells and regulatory mechanisms in HIV-infected immune non-responders
Immune non-responder after highly active antiretroviral therapy (HAART) is the main cause of opportunistic infections and high mortality in AIDS...
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The role of the immune system in idiopathic nephrotic syndrome
Idiopathic nephrotic syndrome (INS) in children is characterized by massive proteinuria and hypoalbuminemia and usually responds well to steroids....
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Overview and Current Advances in Dapsone Hypersensitivity Syndrome
Purpose of ReviewAs a sulfone antibacterial agent, dapsone has been widely used to treat leprosy. Moreover, dapsone is also used in many immune...
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Unmasking lymphoma immune reconstitution inflammatory syndrome in a patient with pyrexia of unknown origin: a case report
BackgroundImmune reconstitution inflammatory syndrome (IRIS) is a constellation of inflammatory disorders that are unmasked after the initiation of...
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Engraftment Syndrome Post Stem Cell Transplant
The engraftment syndrome is a complication due to the engraftment of stem cells in patients undergoing stem cell transplantation (SCT) which...
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Potential of extracellular vesicles for early prediction of severity and potential risk stratification in critical inflammatory diseases
Some acute inflammatory diseases are often exacerbated during or after hospitalization, leading to some severe manifestations like systemic...
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Comparison of infection and human immune responses of two SARS-CoV-2 strains in a humanized hACE2 NIKO mouse model
The COVID-19 pandemic has sickened millions, cost lives and has devastated the global economy. Various animal models for experimental infection with...
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Environmental Impact on Immune System
Environmental influences, either social or physical, can affect any aspect of human health, from disease onset (accumulating in their effects...
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p53 suppresses MHC class II presentation by intestinal epithelium to protect against radiation-induced gastrointestinal syndrome
Radiation-induced gastrointestinal syndrome is a major complication and limiting factor for radiotherapy. Tumor suppressor p53 has a protective role...
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Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19
Pediatric Coronavirus Disease 2019 (pCOVID-19) is rarely severe; however, a minority of children infected with severe acute respiratory syndrome...
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Emergomycosis
Emergomycosis is an invasive fungal disease caused by dimorphic fungi from the recently described Onyenalean genus, Emergomyces. The disease has been...
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Immune Checkpoint Inhibitors
Immune costimulatory checkpoints are crucial in regulating both lymphocyte activation and function. They also serve a major role in foreign antigen...
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Expanding Concept of Immune Reconstitution Inflammatory Syndrome: A New View Regarding How the Immune System Fights Exogenous Pathogens
Increased occurrence of opportunistic infections has been reported coincident with restoration of host CD4+ T cell number and reactivity: rapid...
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Mesenchymal stromal cells (MSCs) as a therapeutic agent of inflammatory disease and infectious COVID-19 virus: live or dead mesenchymal?
The COVID-19 infection is a worldwide disease that causes numerous immune-inflammatory disorders, tissue damage, and lung dysfunction. COVID-19...
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α4 Integrins in Immune Homeostasis and Disease
α4 integrins (including α4β1 and α4β7) are primarily expressed on leukocytes. By interacting with their ligands expressed on high endothelial venules...
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Difficulty in diagnosing intracranial infection caused by Mycobacterium avium in an AIDS patient: case report and review of the literature
BackgroundMycobacterium avium complex (MAC) is an uncommon clinical pathogen, especially in the central nervous system (CNS), and carries a poor...
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A potential mechanism of the onset of immune-related pneumonitis triggered by anti-PD-1 treatment in a patient with advanced adenocarcinoma lung cancer: case report
BackgroundIn recent years, the application of immunotherapy combined with chemotherapy in the first-line lung cancer has showed significant benefit...
