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1. Interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist

   Lymphocystis disease virus-1 (LCDV-1) and several other Iridoviridae encode viral insulin/IGF-1 like peptides (VILPs) with high homology to human...

   Francois Moreau, Nicholas S. Kirk, ... C. Ronald Kahn in Nature Communications

   Article Open access 05 November 2022
   

2. Noncoding RNA actions through IGFs and IGF binding proteins in cancer

   The insulin-like growth factors (IGFs) and their regulatory proteins—IGF receptors and binding proteins—are strongly implicated in cancer progression...

   Aidan Kerr, Robert C. Baxter in Oncogene

   Article Open access 21 May 2022
   

3. Correlation between serum IGF-1 and EGF levels and neuropsychiatric and cognitive in Parkinson’s disease patients

   Background

   Insulin-like growth factor 1 (IGF-1) and epidermal growth factor (EGF) exert neuroprotective effects in Parkinson’s disease (PD). To date,...

   **aoxue Shi, **hua Zheng, ... Mingjian Li in Neurological Sciences

   Article Open access 16 November 2022
   

4. The involvement of Akt, mTOR, and S6K in the in vivo effect of IGF-1 on the regulation of rat cardiac Na⁺/K⁺-ATPase

   Background

   We previously demonstrated that insulin-like growth factor-1 (IGF-1) regulates sodium/potassium adenosine triphosphatase (Na ⁺ /K ⁺ -ATPase)...

   Katarina Banjac, Milan Obradovic, ... Esma R. Isenovic in Molecular Biology Reports

   Article 15 April 2024
   

5. Evaluation of recombinant human IGF-1/IGFBP-3 on intraventricular hemorrhage prevention and survival in the preterm rabbit pup model

   Insulin-like growth factor-1 (IGF-1) is essential for normal brain development and regulates processes of vascular maturation. The pathogenesis of...

   Claes Ekström, Niklas Ortenlöf, ... Magnus Gram in Scientific Reports

   Article Open access 13 November 2023
   

6. Potential role of IGF-1R in the interaction between orbital fibroblasts and B lymphocytes: an implication for B lymphocyte depletion in the active inflammatory phase of thyroid-associated ophthalmopathy

   Background

   Thyroid eye disease (TED) is an inflammatory process involving lymphocyte-mediated immune response and orbital tissue damage. The...

   Renyan Wang, Delu Song, ... Hui Li in BMC Immunology

   Article Open access 11 May 2024
   

7. A variant rs6214 within IGF-1 confers risk for ulcerative colitis in Chinese Han populations

   Insulin growth factor-1 (IGF-1) has been found to correlate with various diseases such as cancer and cardiovascular diseases including ulcerative...

   Hui** Wang, ** Wang, ... Zhansheng Zhu in Functional & Integrative Genomics

   Article 15 December 2022
   

8. Inhibition of the epigenetically activated miR-483-5p/IGF-2 pathway results in rapid loss of meningioma tumor cell viability

   Purpose

   Meningioma is the most common primary central nervous system tumor often causing serious complications, and presently no medical treatment is...

   Erik J. Uhlmann, Charles E. Mackel, ... Anna M. Krichevsky in Journal of Neuro-Oncology

   Article Open access 21 February 2023
   

9. Mouse model of Graves’ orbitopathy induced by the immunization with TSHR A and IGF-1R α subunit gene

   Purpose

   The study aimed to establish a mouse model of Graves’ disease (GD) with Graves’ orbitopathy (GO; GD + GO) that can represent the clinical...

   R. Wu, N. Li, ... W. Zheng in Journal of Endocrinological Investigation

   Article 25 April 2024
   

10. Alterations in Stem Cell Populations in IGF-1 Deficient Pediatric Patients Subjected to Mecasermin (Increlex) Treatment

    Pathway involving insulin-like growth factor 1 (IGF-1) plays significant role in growth and development. Crucial role of IGF-1 was discovered inter...

    Grubczak Kamil, Stożek Karolina, ... Moniuszko Marcin in Stem Cell Reviews and Reports

    Article Open access 21 October 2022
    

11. IGF-1R down regulates the sensitivity of hepatocellular carcinoma to sorafenib through the PI3K / akt and RAS / raf / ERK signaling pathways

    Background

    Insulin-like growth factor-1 receptor (IGF-1R) promotes cell proliferation and migration and inhibitsapoptosis, all of which can contribute...

    Wenpeng Cai, Yongfang Ma, ... **aolong Tang in BMC Cancer

    Article Open access 25 January 2023
    

12. An IGF-1R-mTORC1-SRPK2 signaling Axis contributes to FASN regulation in breast cancer

    Background

    Fatty acid synthase (FASN) expression is associated with a more aggressive breast cancer phenotype and is regulated downstream of receptor...

    Bryan McClellan, Paul Gries, ... Linda deGraffenried in BMC Cancer

    Article Open access 12 September 2022
    

13. BDNF, proBDNF and IGF-1 serum levels in naïve and medicated subjects with autism

    Brain-derived neurotrophic factor (BDNF) and insulin-like growth factor 1 (IGF-1) promote the development and maintenance of neural circuits....

    Maria de los Angeles Robinson-Agramonte, Bernadeta Michalski, ... Margaret Fahnestock in Scientific Reports

    Article Open access 12 August 2022
    

14. CBX1 is involved in hepatocellular carcinoma progression and resistance to sorafenib and lenvatinib via IGF-1R/AKT/SNAIL signaling pathway

    Background

    Chromobox Homolog 1 (CBX1) plays a crucial role in the pathogenesis of numerous diseases, including the evolution and advancement of...

    Su-Su Zheng, **g-Fang Wu, ... Bo-Heng Zhang in Hepatology International

    Article Open access 20 May 2024
    

15. Determinants of IGF-II influencing stability, receptor binding and activation

    Insulin like growth factor II (IGF-II) is involved in metabolic and mitogenic signalling in mammalian cells and plays important roles in normal fetal...

    Andrew Blyth, Michael Ortiz, ... Briony Forbes in Scientific Reports

    Article Open access 18 March 2022
    

16. Serum IGF-1 levels are associated with sarcopenia in elderly men but not in elderly women

    Background

    Sarcopenia is an age-associated decline in muscle mass that negatively affects the metabolic rate, strength, and function of the body and...

    **g-** Jiang, Si-min Chen, ... Qin Zhang in Aging Clinical and Experimental Research

    Article 13 August 2022

17. IGF-1 increases survival of CD4⁺ lineage in a 2D model of thymocyte/thymic stromal cell co-culture

    Insulin-like growth factor-1 (IGF-1), in addition to its classic effects on cell proliferation and organism growth, has pleiotropic actions on the...

    Larissa Fernanda de Araújo Vieira, Marvin Paulo Lins, ... Maria Danielma dos Santos Reis in In Vitro Cellular & Developmental Biology - Animal

    Article 18 November 2022
    

18. Structural basis for assembly and disassembly of the IGF/IGFBP/ALS ternary complex

    Insulin-like growth factors (IGFs) have pleiotropic roles in embryonic and postnatal growth and differentiation. Most serum IGFs are bound in a...

    Hyo** Kim, Yaoyao Fu, ... Ho Min Kim in Nature Communications

    Article Open access 30 July 2022
    

19. The clinicopathological and prognostic significances of IGF-1R and Livin expression in patients with colorectal cancer

    Background

    Colorectal cancer (CRC) is the third most common cancer worldwide. However, limited effective biomarkers are associated with the...

    Zhenling Zhang, Yuxin Zhang, ... **aoying Feng in BMC Cancer

    Article Open access 05 August 2022
    

20. Effects of exercise on inflammatory factors and IGF system in breast cancer survivors: a meta-analysis

    Background

    At present, there are multiple hypotheses regarding the mechanisms underlying the effect of exercise on the postoperative inflammatory...

    Yanan Zhou, Ningxin Jia, ... Kai Yuan in BMC Women's Health

    Article Open access 08 December 2022