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Machine learning-aided search for ligands of P2Y6 and other P2Y receptors
The P2Y 6 receptor, activated by uridine diphosphate (UDP), is a target for antagonists in inflammatory, neurodegenerative, and metabolic disorders,...
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Three-dimensional environment sensitizes pancreatic cancer cells to the anti-proliferative effect of budesonide by reprogramming energy metabolism
BackgroundPancreatic ductal adenocarcinoma (PDAC) is the most lethal cancer with an aggressive metastatic phenotype and very poor clinical prognosis....
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Evaluation of Antimicrobial Activity of Aryl/Alkyl Cyanamides and Substituted Tetrazole Compounds
AbstractCyanamides, tetrazole and their derivatives have pharmaceutically attracted much attention because of their wide range of biological...
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Isthmin-1 attenuates allergic Asthma by stimulating adiponectin expression and alveolar macrophage efferocytosis in mice
BackgroundAllergic asthma is a common respiratory disease that significantly impacts human health. Through in silico analysis of human lung RNASeq,...
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Young People with Asthma on Vacation at Aqua Park—Esmeraldas
This article focuses on providing general information about Esmeraldas, one of the twenty-four provinces that make up the Republic of Ecuador. It...
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Exploring the therapeutic potential of monoclonal antibodies targeting TSLP and IgE in asthma management
BackgroundIn recent years, there has been a growing interest in the utilization of biologic therapies for the management of asthma. Both TSLP and IgE...
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Airway and Systemic Immunoglobulin Profiling and Immune Response in Adult Asthma
IntroductionImmunoglobulins play a vital role in host immune response and in the pathogenesis of conditions like asthma. Therapeutic agents such as...
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Phytomolecules and Novel Drug Delivery Approach for COVID-19
Coronavirus disease 2019 (COVID-19) has been a recent pandemic where very rarely few therapeutic modalities are effective in the treatment and...
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CpG oligodeoxynucleotides attenuate RORγt-mediated Th17 response by restoring histone deacetylase-2 in cigarette smoke-exposure asthma
BackgroundCigarette smoke (CS) exposure increases corticosteroid insensitive asthma related to increased Th17 phenotype, and new treatment strategies...
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Anesthetic Management in Nasal Polypectomy
Nasal polypectomy surgery requires a careful and cautious perioperative management, especially due to its association with Samter’s triad. A detailed...
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The Effect of Anti-Chemokine Oral Drug XC8 on Cough Triggered by The Agonists of TRPA1 But Not TRPV1 Channels in Guinea Pigs
IntroductionChronic cough heavily affects patients’ quality of life, and there are no effective licensed therapies available. Cough is a complication...
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Beneficial role of kaempferol and its derivatives from different plant sources on respiratory diseases in experimental models
Respiratory illnesses impose a significant health burden and cause deaths worldwide. Despite many advanced strategies to improve patient outcomes,...
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Chronic urticaria associated with Blastocystis hominis infection
Urticaria is a skin rash with several etiologic factors, including infectious agents. Blastocystis hominis is an intestinal protozoan parasite that...
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In silico studies of bioactive compounds from selected African plants with inhibitory activity against nitric oxide synthase and arginase implicated in asthma
BackgroundIt is a known fact that arginine is a common substrate for arginase and nitric oxide synthase (NOS). However, an imbalance between both...
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Natural drug sources for respiratory diseases from Fritillaria: chemical and biological analyses
Fritillaria naturally grows in the temperate region of Northern Hemisphere and mainly distributes in Central Asia, Mediterranean region, and North...
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Inhaled Corticosteroids in Adults with Non-cystic Fibrosis Bronchiectasis: From Bench to Bedside. A Narrative Review
Due to their potent anti-inflammatory capacity (particularly in predominantly eosinophilic inflammation) and immunosuppressive properties, inhaled...
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Noninvasive Mechanical Ventilation After Chemical Disasters
Mass casualty is caused by exposure to chemical agents or natural environmental exposure. The clinical presentations depend to the intensity of the...
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Exploring the Impact of Airway Microbiome on Asthma Morbidity: A Focus on the “Constructing a ‘Eubiosis Reinstatement Therapy’ for Asthma—CURE” Project
The asthma pandemic imposes a huge burden on patients and health systems in both developed and develo** countries. Despite available treatments,...
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Noninvasive Mechanical Ventilation After Chemical Disasters
Mass casualty is caused by exposure to chemical agents or natural environmental exposure. The clinical presentations depend on the intensity of the...
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Nutraceuticals and mitochondrial oxidative stress: bridging the gap in the management of bronchial asthma
Asthma is a chronic inflammatory disease primarily characterized by inflammation and reversible bronchoconstriction. It is currently one of the...
