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Amyloid Light Chain (AL) Amyloidosis
Amyloid light chain (AL) amyloidosis is one of the most frequent forms of amyloidosis. In this condition, a plasma cell clone produces monoclonal...
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Outcome prediction by interim positron emission tomography and IgM monoclonal gammopathy in diffuse large B-cell lymphoma
In diffuse large B-cell lymphoma (DLBCL), a positive interim positron emission tomography (PET) scan predicts treatment failure, but the proportion...
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Tubulointerstitial nephritis with IgA kappa-positive plasma cells in a patient with primary Sjögren’s syndrome and monoclonal gammopathy
This is a case report of a 69-year-old Japanese man who has been undergoing treatment for primary Sjögren’s syndrome (pSS) since he was 62 years. A...
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A nationwide study of patients with monoclonal gammopathy of undetermined significance with a 10-year follow-up in South Korea
In clinical practice, most patients with monoclonal gammopathy of undetermined significance (MGUS) undergo long-term follow-up without disease...
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Therapeutic Monoclonal Antibody Therapies in Chronic Autoimmune Demyelinating Neuropathies
Autoimmune diseases of the peripheral nervous system have so far been treated mainly with exogenous high-dose intravenous immunoglobulins (IVIg),...
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Monoclonal Gammopathy of Renal Significance: An Insight
The term monoclonal gammopathy of renal significance (MGRS) was first introduced by the International Kidney and Monoclonal Gammopathy Research Group...
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IgA vasculitis with underlying monoclonal IgA gammopathy: innovative therapeutic approach targeting plasma cells. A case series
ObjectiveThere is currently no evidence of the possible benefit of plasma cell–targeting therapies (PCTT) in immunoglobulin A (IgA) monoclonal...
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Tubulointerstitial nephritis in antineutrophil cytoplasmic antibody-associated vasculitis with monoclonal gammopathy
Isolated tubulointerstitial nephritis (TIN) without glomerular crescent formation is a rare manifestation of antineutrophil cytoplasmic antibody...
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The presence of two light chain bands on immunofixation is associated with poor outcomes in newly diagnosed multiple myeloma patients
We aimed to describe the clinical and biological characteristics and the prognosis of patients presenting with an additional light chain (LC) band...
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Yellowish Erythematous Desquamative Lesion in a Middle Aged Man
Diffuse plane normolipaemic xanthomatosis is a rare form of acquired non-Langerhans histiocytosis showing as yellowish plaques of the skin and of the...
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IgA Monoclonal Gammopathy with Pseudohyperphosphatemia
Monoclonal gammopathies (MGs) reflect conditions in which abnormal amounts of immunoglobulins are produced by a clone that developed from a single...
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An N-glycosylation hotspot in immunoglobulin κ light chains is associated with AL amyloidosis
Immunoglobulin light chain (AL) amyloidosis is caused by a small, minimally proliferating B-cell/plasma-cell clone secreting a patient-unique,...
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A multidisciplinary case report of multiple myeloma with renal and cardiac involvement: a look beyond amyloidosis
BackgroundMultiple myeloma (MM) is a malignant neoplasm associated with kidney involvement in nearly half of the patients. Cast nephropathy,...
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MASS-FIX for the detection of monoclonal proteins and light chain N-glycosylation in routine clinical practice: a cross-sectional study of 6315 patients
Immunoenrichment-based matrix assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS), termed MASS-FIX, offers several...
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Polyclonal serum free light chain elevation is associated with increased risk of monoclonal gammopathies
Monoclonal gammopathies (MG) constitute a spectrum of disorders starting from a monoclonal gammopathy of undetermined significance (MGUS) to active...
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Neutrophilic Dermatosis
Neutrophilic dermatoses are a clinically heterogeneous group of diseases that primarily present neutrophilic infiltration in skin tissues. This...
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Jan Waldenström. An Esteemed Globetrotter
JWJW was awarded with seven honorary doctorates and countless prizes. He was the third winner of the big Nordic Jahre Prize in Oslo succeeding...
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Immune biomarkers to predict SARS-CoV-2 vaccine effectiveness in patients with hematological malignancies
There is evidence of reduced SARS-CoV-2 vaccine effectiveness in patients with hematological malignancies. We hypothesized that tumor and...
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First case report of pre-mortem biopsy-proven kidney involvement by necrobiotic xanthogranuloma with monoclonal gammopathy
Necrobiotic xanthogranuloma (NXG) is a rare non-Langerhans cell histiocytosis with characteristic cutaneous features and rare visceral involvement....
