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Production of the Extracellular Part of the ErbB2 Receptor for the Study of Immunobiologicals
Abstract —The extracellular part of the ErbB2 receptor (ecdErbB2), an oncological marker and a target for therapeutic antibodies, has been expressed...
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The Role of ERBB2/HER2 Tyrosine Kinase Receptor in the Regulation of Cell Death
AbstractHER2 (Human Epidermal Growth Factor Receptor 2), also known as ERBB2, CD340, and Neu protooncogene, is a member of the epidermal growth...
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Imaging strategies for receptor tyrosine kinase dimers in living cells
Receptor tyrosine kinases (RTKs) are the essential regulators of cell signal transduction pathways and play important roles in biological processes....
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Regulatory chromatin rewiring promotes metabolic switching during adaptation to oncogenic receptor tyrosine kinase inhibition
Oesophageal adenocarcinoma (OAC) patients show poor survival rates and there are few targeted molecular therapies available. However, components of...
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Mathematical model of the cell signaling pathway based on the extended Boolean network model with a stochastic process
BackgroundIn cell signaling pathways, proteins interact with each other to determine cell fate in response to either cell-extrinsic...
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Molecular insights of exercise therapy in disease prevention and treatment
Despite substantial evidence emphasizing the pleiotropic benefits of exercise for the prevention and treatment of various diseases, the underlying...
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microRNA miR-133a as a Biomarker for Doxorubicin-Induced Cardiotoxicity in Women with Breast Cancer: A Signaling Pathway Investigation
Cardiovascular toxicity is the main adverse effect of Doxorubicin (DOX) in cancer patients. microRNAs (miRNAs) are promising biomarkers to identify...
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The prognostic significance and potential mechanism of DBF4 zinc finger in hepatocellular carcinoma
DBF4 zinc finger (DBF4) is a critical component involved in DNA replication and cell proliferation. It acts as a positive regulator of the cell...
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Loss of Kmt2c in vivo leads to EMT, mitochondrial dysfunction and improved response to lapatinib in breast cancer
Deep sequencing of human tumours has uncovered a previously unappreciated role for epigenetic regulators in tumorigenesis. H3K4 methyltransferase KMT2C/MLL3...
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Oncogenes
Oncogenes are one important type of cancer gene and act in a dominant mode. They were first discovered in cancer-causing viruses. Retroviral...
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The role of kinesin family members in hepatobiliary carcinomas: from bench to bedside
As a major component of the digestive system malignancies, tumors originating from the hepatic and biliary ducts seriously endanger public health....
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Insulin and the insulin receptor collaborate to promote human gastric cancer
BackgroundGastric adenocarcinoma is common and consequent mortality high. Presentation and mortality are increased in obese individuals, many of whom...
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Alteration in tyrosine phosphorylation of cardiac proteome and EGFR pathway contribute to hypertrophic cardiomyopathy
Alterations of serine/threonine phosphorylation of the cardiac proteome are a hallmark of heart failure. However, the contribution of tyrosine...
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Disentangling oncogenic amplicons in esophageal adenocarcinoma
Esophageal adenocarcinoma is a prominent example of cancer characterized by frequent amplifications in oncogenes. However, the mechanisms leading to...
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Signal Transduction in Radiation Oncology
Processes in cells in the human body and other organisms are controlled by specific and tightly regulated events. These events are called signal...
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Computational Analysis of Differentially Expressed Circulating MicroRNA and Identification of Key Genes in Prostate Cancer
Bioinformatics is considered a powerful tool to investigate and deeply analyze large datasets. A significant quantity of data is generated by...
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Role of glycosyltransferases in carcinogenesis; growth factor signaling and EMT/MET programs
The glycosylation of cell surface receptors has been shown to regulate each step of signal transduction, including receptor trafficking to the cell...
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BET-directed PROTACs in triple negative breast cancer cell lines MDA-MB-231 and MDA-MB-436
PurposeThis study aims to find whether the proliferation and migration of triple negative breast cancer (TNBC) cell lines can be reduced by treatment...
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Molecular Pathology of Endometrial Tumors
In the Western world, endometrial carcinoma is the most common malignant tumor of the female genital tract. The annual incidence has been estimated...