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  1. Current Treatment Landscape for Third- or Later-Line Therapy in Metastatic Colorectal Cancer

    Purpose of Review

    The aim of this paper is to summarize the current treatment landscape in metastatic colorectal cancer, as well as those on the...

    Sadaf Qureshi, Lyudmyla Berim, Patrick M. Boland in Current Colorectal Cancer Reports
    Article 23 October 2021
  2. Treatment Refractory Metastatic Colorectal Cancer

    Patients with metastatic colorectal cancer are treated with biochemotherapy in the first-line setting with promising response rates. However, most...
    Ryan Huey, Kanwal Raghav in Colorectal Liver Metastasis
    Chapter 2022
  3. Systematic review and network meta-analyses of third-line treatments for metastatic colorectal cancer

    Background

    Limited treatment options are available in chemotherapy-refractory metastatic colorectal cancer (mCRC). The objective was to conduct a...

    Thomas Walter, Neil S. Hawkins, ... Paul J. Ross in Journal of Cancer Research and Clinical Oncology
    Article Open access 27 July 2020
  4. Feasibility of 7-T fluorine magnetic resonance spectroscopic imaging (19F MRSI) for TAS-102 metabolite detection in the liver of patients with metastatic colorectal cancer

    Trifluridine/tipiracil (TAS-102) has shown a significant overall survival benefit in patients with heavily pre-treated metastatic colorectal cancer....

    Sophie A. Kurk, Bart R. Steensma, ... Wybe J. M. van der Kemp in European Radiology Experimental
    Article Open access 11 July 2018
  5. Estimation of cellular carbon content based on the cell biovolume of microalgae from a eutrophic estuary (Sea of Marmara, Türkiye)

    The cellular carbon content based on the cell biovolume of a total of 61 microalgal species determined in a eutrophic estuary (Golden Horn, Sea of...

    Article 11 September 2023
  6. Monitoring arsenic species concentration in rice-based processed products distributed in South Korean markets and related risk assessment

    Rice is an important grain as a major source of carbohydrates in Asia but contains more arsenic (As) than other grains. A total of 239 rice-based...

    Chang-Hyun Noh, Su-Hyun Chun, ... Kwang-Won Lee in Food Science and Biotechnology
    Article 07 March 2023
  7. Metastasiertes kolorektales Karzinom – moderne Therapiestrategien und -sequenzen

    The treatment of metastatic colorectal cancer (mCRC) has been considerably expanded and relevantly improved in recent years with new strategies, such...

    T. J. Ettrich, J. S. Schuhbaur, Thomas Seufferlein in Die Onkologie
    Article 30 January 2024
  8. The colorectal cancer drug market

    Laura Ramos García, Rachel M. Webster in Nature Reviews Drug Discovery
    Article 09 February 2024
  9. New Developments in Treating RAS-Mutated Metastatic Colorectal Cancer

    One of the great challenges in digestive oncology is choosing the optimal therapy for RAS -mutated metastatic colorectal cancer (mCRC). Even though...

    Katleen Janssens, Chinouk Lambrechts, ... Marc Peeters in Current Treatment Options in Oncology
    Article 22 May 2023
  10. Chemotherapy re-use versus anti-angiogenic monotherapy as the third-line treatment of patients with metastatic colorectal cancer: a real-world cohort study

    Background

    There are various recommendations for third-line treatment in mCRC, however, there is no consensus on who is more suitable for particular...

    **g**g Duan, Lila Zhu, ... Ting Deng in BMC Cancer
    Article Open access 05 March 2024
  11. Clinical outcomes of chemotherapy-based therapies for previously treated advanced colorectal cancer: a systematic literature review and meta-analysis

    Purpose

    The purpose of this study was to evaluate clinical outcomes of standard therapies in previously treated, advanced colorectal cancer (CRC)...

    Mayur M. Amonkar, Lauren A. Abderhalden, ... Ina Zhang in International Journal of Colorectal Disease
    Article 11 January 2023
  12. Improving fission-product decay data for reactor applications: part I—decay heat

    Effort has been expended to assess the relative merits of undertaking further decay-data measurements of the main fission-product contributors to the...

    A. L. Nichols, P. Dimitriou, ... J. L. Tain in The European Physical Journal A
    Article Open access 13 April 2023
  13. Update on the management of elderly patients with colorectal cancer

    Colorectal cancer (CRC) is one of the most common tumours worldwide, and 70% of CRC patients are over 65 years of age. However, the scientific...

    Gemma Soler-González, Javier Sastre-Valera, ... Regina Gironés-Sarrió in Clinical and Translational Oncology
    Article Open access 27 July 2023
  14. Metastasiertes kolorektales Karzinom – moderne Therapiestrategien und -sequenzen

    The treatment of metastatic colorectal cancer (mCRC) has been considerably expanded and relevantly improved in recent years with new strategies, such...

    T. J. Ettrich, J. S. Schuhbaur, T. Seufferlein in Die Innere Medizin
    Article 24 May 2023
  15. New Estimates on the Cost of a Delay Day in Drug Development

    Two frequently cited figures by clinical research insiders and observers – the cost of missing a day to generate prescription drug sales and the cost...

    Zachary P. Smith, Joseph A. DiMasi, Kenneth A. Getz in Therapeutic Innovation & Regulatory Science
    Article 21 May 2024
  16. A synthetic control arm for refractory metastatic colorectal cancer: the no placebo initiative

    Takayuki Yoshino, Qian Shi, ... Aimery de Gramont in Nature Medicine
    Article 28 July 2023
  17. SEOM-GEMCAD-TTD clinical guidelines for the systemic treatment of metastatic colorectal cancer (2022)

    Colorectal cancer (CRC) is the second leading cause of cancer deaths in Spain. Metastatic disease is present in 15–30% of patients at diagnosis and...

    Ana Fernández Montes, Vicente Alonso, ... Jorge Aparicio in Clinical and Translational Oncology
    Article Open access 03 May 2023
  18. Impact of axillary surgery on outcome of clinically node positive breast cancer treated with neoadjuvant chemotherapy

    Purpose

    Axillary Lymph Node Dissection (ALND) is recommended for breast cancer patients who present with clinically node positive disease (cN1)...

    Joseph Dux, Mehran Habibi, ... David Euhus in Breast Cancer Research and Treatment
    Article 02 August 2023
  19. Geospatial analysis of Plasmodium falciparum serological indicators: school versus community sampling in a low-transmission malaria setting

    Background

    Due to low numbers of active infections and persons presenting to health facilities for malaria treatment, case-based surveillance is...

    Alicia Jaramillo-Underwood, Camelia Herman, ... Eric Rogier in BMC Medicine
    Article Open access 23 January 2024
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