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Current Treatment Landscape for Third- or Later-Line Therapy in Metastatic Colorectal Cancer
Purpose of ReviewThe aim of this paper is to summarize the current treatment landscape in metastatic colorectal cancer, as well as those on the...
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Treatment Refractory Metastatic Colorectal Cancer
Patients with metastatic colorectal cancer are treated with biochemotherapy in the first-line setting with promising response rates. However, most... -
Systematic review and network meta-analyses of third-line treatments for metastatic colorectal cancer
BackgroundLimited treatment options are available in chemotherapy-refractory metastatic colorectal cancer (mCRC). The objective was to conduct a...
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Feasibility of 7-T fluorine magnetic resonance spectroscopic imaging (19F MRSI) for TAS-102 metabolite detection in the liver of patients with metastatic colorectal cancer
Trifluridine/tipiracil (TAS-102) has shown a significant overall survival benefit in patients with heavily pre-treated metastatic colorectal cancer....
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Estimation of cellular carbon content based on the cell biovolume of microalgae from a eutrophic estuary (Sea of Marmara, Türkiye)
The cellular carbon content based on the cell biovolume of a total of 61 microalgal species determined in a eutrophic estuary (Golden Horn, Sea of...
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Monitoring arsenic species concentration in rice-based processed products distributed in South Korean markets and related risk assessment
Rice is an important grain as a major source of carbohydrates in Asia but contains more arsenic (As) than other grains. A total of 239 rice-based...
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Metastasiertes kolorektales Karzinom – moderne Therapiestrategien und -sequenzen
The treatment of metastatic colorectal cancer (mCRC) has been considerably expanded and relevantly improved in recent years with new strategies, such...
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New Developments in Treating RAS-Mutated Metastatic Colorectal Cancer
One of the great challenges in digestive oncology is choosing the optimal therapy for RAS -mutated metastatic colorectal cancer (mCRC). Even though...
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Chemotherapy re-use versus anti-angiogenic monotherapy as the third-line treatment of patients with metastatic colorectal cancer: a real-world cohort study
BackgroundThere are various recommendations for third-line treatment in mCRC, however, there is no consensus on who is more suitable for particular...
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Clinical outcomes of chemotherapy-based therapies for previously treated advanced colorectal cancer: a systematic literature review and meta-analysis
PurposeThe purpose of this study was to evaluate clinical outcomes of standard therapies in previously treated, advanced colorectal cancer (CRC)...
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Improving fission-product decay data for reactor applications: part I—decay heat
Effort has been expended to assess the relative merits of undertaking further decay-data measurements of the main fission-product contributors to the...
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Update on the management of elderly patients with colorectal cancer
Colorectal cancer (CRC) is one of the most common tumours worldwide, and 70% of CRC patients are over 65 years of age. However, the scientific...
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Metastasiertes kolorektales Karzinom – moderne Therapiestrategien und -sequenzen
The treatment of metastatic colorectal cancer (mCRC) has been considerably expanded and relevantly improved in recent years with new strategies, such...
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New Estimates on the Cost of a Delay Day in Drug Development
Two frequently cited figures by clinical research insiders and observers – the cost of missing a day to generate prescription drug sales and the cost...
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SEOM-GEMCAD-TTD clinical guidelines for the systemic treatment of metastatic colorectal cancer (2022)
Colorectal cancer (CRC) is the second leading cause of cancer deaths in Spain. Metastatic disease is present in 15–30% of patients at diagnosis and...
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Impact of axillary surgery on outcome of clinically node positive breast cancer treated with neoadjuvant chemotherapy
PurposeAxillary Lymph Node Dissection (ALND) is recommended for breast cancer patients who present with clinically node positive disease (cN1)...
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Geospatial analysis of Plasmodium falciparum serological indicators: school versus community sampling in a low-transmission malaria setting
BackgroundDue to low numbers of active infections and persons presenting to health facilities for malaria treatment, case-based surveillance is...