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The regulation and differentiation of regulatory T cells and their dysfunction in autoimmune diseases
The discovery of FOXP3 + regulatory T (T reg ) cells as a distinct cell lineage with a central role in regulating immune responses provided a deeper...
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Dihydroartemisinin inhibits follicular helper T and B cells: implications for systemic lupus erythematosus treatment
Systemic lupus erythematosus (SLE) is a common autoimmune disease, and its pathogenesis mainly involves the aberrant activation of B cells through...
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Regulatory T cells in autoimmune kidney diseases and transplantation
Regulatory T (T reg ) cells that express the transcription factor forkhead box protein P3 (FOXP3) are naturally present in the immune system and have...
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The phosphatase PTEN links platelets with immune regulatory functions of mouse T follicular helper cells
Beyond a function in hemostasis and thrombosis, platelets can regulate innate and adaptive immune responses. Hyperactive platelets are frequently...
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Regulatory T cells in the face of the intestinal microbiota
Regulatory T cells (T reg cells) are key players in ensuring a peaceful coexistence with microorganisms and food antigens at intestinal borders....
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Intratumoral follicular regulatory T cells curtail anti-PD-1 treatment efficacy
Immune-checkpoint blockade (ICB) has shown remarkable clinical success in boosting antitumor immunity. However, the breadth of its cellular targets...
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The link between circulating follicular helper T cells and autoimmunity
Follicular helper T (T FH ) cells provide help to B cells, supporting the formation of germinal centres that allow affinity maturation of antibody...
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IL6 suppresses vaccine responses in neonates by enhancing IL2 activity on T follicular helper cells
The inability of neonates to develop CD4 + FoxP3 - CXCR5 hi PD-1 hi T follicular helper (T FH ) cells contributes to their weak vaccine responses. In previous...
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CaMK4 controls follicular helper T cell expansion and function during normal and autoimmune T-dependent B cell responses
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by dysregulated B cell compartment responsible for the production of...
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Interleukin-21 modulates balance between regulatory T cells and T-helper 17 cells in chronic hepatitis B virus infection
BackgroundChronic HBV infection is always accompanied by differences in the balance between regulatory T cells (Tregs) and T-helper 17 (Th17) cells...
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Tumor heterogeneity and immune-evasive T follicular cell lymphoma phenotypes at single-cell resolution
T follicular helper (T FH ) cell lymphomas (TFHLs) are characterized by T FH -like properties and accompanied by substantial immune-cell infiltration...
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PD-L1- and IL-4-expressing basophils promote pathogenic accumulation of T follicular helper cells in lupus
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by anti-nuclear autoantibodies whose production is promoted by autoreactive...
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Differentiation, functions, and roles of T follicular regulatory cells in autoimmune diseases
T follicular helper cells participate in stimulating germinal center (GC) formation and supporting B cell differentiation and autoantibody...
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Analysis of T follicular and T peripheral helper lymphocytes in autoimmune thyroid disease
PurposePeripheral helper T (Tph) cells have an important role in the induction of humoral immune responses and autoantibody production. Accordingly,...
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Induced regulatory T cells remain suppressive capability on effector T cells and synovial fibroblasts in collagen-induced arthritis
Rheumatoid arthritis (RA) is a common autoimmune disorder initiated by inflammatory synovitis. Hyperproliferation of destructive synovial fibroblasts...
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Imbalance of circulating CTLA4+ follicular helper and follicular regulatory T cells in obstetric antiphospholipid syndrome
Obstetric antiphospholipid syndrome (OAPS) is a systemic autoimmune disease that is characterized clinically by a variety of obstetric manifestations...
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Regulatory T cells in skin regeneration and wound healing
As the body’s integumentary system, the skin is vulnerable to injuries. The subsequent wound healing processes aim to restore dermal and epidermal...
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CTLA4 protects against maladaptive cytotoxicity during the differentiation of effector and follicular CD4+ T cells
As chronic antigenic stimulation from infection and autoimmunity is a feature of primary antibody deficiency (PAD), analysis of affected patients...
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Pathogen regulatory RNA usage enables chronic infections, T-cell exhaustion and accelerated T-cell exhaustion
Pathogens evade or disable cellular immune defenses using regulatory ribonucleic acids (RNAs), including microRNAs and long non-coding RNAs....
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Comprehensive Analysis of the miRNA-mRNA Pathological Regulatory Network of Intestinal CD4 + T Cells in Parkinson’s Disease
Infiltration of CD4 + T cells was found in brain tissue samples from PD patients, suggesting their involvement in develo** central nervous system...
