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Mink infection with influenza A viruses: an ignored intermediate host?
Continuously emergence of human infection with avian influenza A virus poses persistent threat to public health, as illustrated in zoonotic H5N1/6...
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Characterization of a reassortant H11N9 subtype avian influenza virus isolated from spot-billed duck in China
H11N9 viruses in wild birds might have provided the NA gene of human H7N9 virus in early 2013 in China, which evolved with highly pathogenic strains...
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Influenza Viruses
Annual epidemics and occasional pandemics of influenza are responsible for a substantial global disease burden related to both the acute effects of...
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Substitution of I222L-E119V in neuraminidase from highly pathogenic avian influenza H7N9 virus exhibited synergistic resistance effect to oseltamivir in mice
That the high frequency and good replication capacity of strains with reduced susceptibility to neuraminidase inhibitors (NAIs) in highly pathogenic...
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Adjuvanted recombinant hemagglutinin H7 vaccine to highly pathogenic influenza A(H7N9) elicits high and sustained antibody responses in healthy adults
An unprecedented number of human infections with avian influenza A(H7N9) in the fifth epidemic wave during the winter of 2016–2017 in China and their...
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Avian Influenza: A Potential Threat to Human Health
Throughout history, emerging viral infections have posed a threat to humanity. Avian influenza viruses (AIVs) are relatively more diverse and can...
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Development of mouse monoclonal antibody for detecting hemagglutinin of avian influenza A(H7N9) virus and preventing virus infection
AbstractMany cases of avian influenza A(H7N9) virus infection in humans have been reported since its first emergence in 2013. The disease is of...
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A small molecule compound targeting hemagglutinin inhibits influenza A virus and exhibits broad-spectrum antiviral activity
Influenza A virus (IAV) is a widespread pathogen that poses a significant threat to human health, causing pandemics with high mortality and...
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A broadly protective human monoclonal antibody targeting the sialidase activity of influenza A and B virus neuraminidases
Improved vaccines and antiviral agents that provide better, broader protection against seasonal and emerging influenza viruses are needed. The viral...
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Expression of the SARS-CoV-2 receptor-binding domain by live attenuated influenza vaccine virus as a strategy for designing a bivalent vaccine against COVID-19 and influenza
Influenza and SARS-CoV-2 are two major respiratory pathogens that cocirculate in humans and cause serious illness with the potential to exacerbate...
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Nanobodies mapped to cross-reactive and divergent epitopes on A(H7N9) influenza hemagglutinin using yeast display
Influenza H7N9 virus continues to cause infections in humans and represents a significant pandemic risk. During the most recent 5th epidemic wave in...
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Avian influenza revisited: concerns and constraints
Avian influenza (AVI) is being known for its pandemic potential and devastating effects on poultry and birds. The AVI outbreaks in domesticated birds...
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Highly pathogenic avian influenza A/Guangdong/17SF003/2016 is immunogenic and induces cross-protection against antigenically divergent H7N9 viruses
Avian influenza A(H7N9) epidemics have a fatality rate of approximately 40%. Previous studies reported that low pathogenic avian influenza...
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A potential Chinese medicine monomer against influenza A virus and influenza B virus: isoquercitrin
BackgroundInfluenza viruses, especially Influenza A virus and Influenza B virus, are respiratory pathogens and can cause seasonal epidemics and...
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A chimeric thermostable M2e and H3 stalk-based universal influenza A virus vaccine
We developed a new chimeric M2e and H3 hemagglutinin (HA) stalk protein vaccine (M2e-H3 stalk) by genetic engineering of modified H3 stalk domain...
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Influenza from a One Health Perspective: Infection by a Highly Versatile Virus
Influenza A viruses (IAVs) are among the most versatile viruses, in terms of host range, pathogenesis, route of transmission, transmissibility...
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Nanoscale Vaccines for Influenza
Influenza, a contagious respiratory illness, spreads easily via contaminated surfaces and air. In majority of the cases, the symptoms are minor,...
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Defining the balance between optimal immunity and immunopathology in influenza virus infection
Influenza A viruses remain a global threat to human health, with continued pandemic potential. In this Review, we discuss our current understanding...
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Influenza virus uses mGluR2 as an endocytic receptor to enter cells
Influenza virus infection is initiated by the attachment of the viral haemagglutinin (HA) protein to sialic acid receptors on the host cell surface....
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Human genes with codon usage bias similar to that of the nonstructural protein 1 gene of influenza A viruses are conjointly involved in the infectious pathogenesis of influenza A viruses
Molecular mechanisms of the non-structural protein 1 (NS1) in influenza A-induced pathological changes remain ambiguous. This study explored the...
