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Differential effects of interleukin-17A and 17F on cell interactions between immune cells and stromal cells from synovium or skin
We compared the contribution of IL-17A and IL-17F in co-culture systems mimicking cell interactions as found in inflamed synovium and skin....
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Increased levels and activation of the IL-17 receptor in microglia contribute to enhanced neuroinflammation in cerebellum of hyperammonemic rats
BackgroundPatients with liver cirrhosis may show minimal hepatic encephalopathy (MHE) with mild cognitive impairment and motor incoordination. Rats...
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Matrine-loaded self-adhesive swelling microneedle for inflammation regulation to improve eczema treatment
Eczema is a common chronic dermatological disease. Conventional treatments exhibit limited efficacy due to fast drug release resulting in short-term...
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Pro-resolving and anti-inflammatory effects of resolvins and protectins in rheumatoid arthritis
Rheumatoid arthritis (RA) is typified by persistent joint inflammation, which leads to the deterioration of bone and cartilage and a reduction in...
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IL-17 in wound repair: bridging acute and chronic responses
Chronic wounds, resulting from persistent inflammation, can trigger a cascade of detrimental effects including exacerbating inflammatory cytokines,...
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Abnormal generation of IL-17A represses tumor infiltration of stem-like exhausted CD8+ T cells to demote the antitumor immunity
BackgroundVariated anti-cancer therapies are combined with immune checkpoint blockades (ICBs) for improving ICB therapeutic efficacy. Occurrence of...
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Loss of Interleukin-17RA Expression is Associated with Tumour Progression in Colorectal Carcinoma
Interleukin-17 (IL-17) is a pro-inflammatory cytokine found in various cancers. Current evidence indicates that IL-17 plays a vital role in tumour...
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Specialized pro-resolving mediators in vascular inflammation and atherosclerotic cardiovascular disease
Timely resolution of the acute inflammatory response (or inflammation resolution) is an active, highly coordinated process that is essential to...
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T Helper Cells Producing Granulocyte-Macrophage Colony Stimulating Factor as a Risk Marker for Coronary Heart Disease
Coronary heart disease (CHD) is related to aberrant aggregation of immune cells in the plaques. This study focused on identification of abnormal T...
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Tumor Necrosis Factor and Interleukin Modulators for Pathologic Pain States: A Narrative Review
Chronic pain, a complex and debilitating condition, involves intricate interactions between central and peripheral inflammatory processes. Cytokines,...
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New insights into the function of Interleukin-25 in disease pathogenesis
Interleukin-25 (IL-25), also known as IL-17E, is a cytokine belonging to the IL-17 family. IL-25 is abundantly expressed by Th2 cells and various...
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Exploring the Effects of Ixekizumab on Pain in Patients with Ankylosing Spondylitis Based on Objective Measures of Inflammation: Post Hoc Analysis from a Large Randomized Clinical Trial
IntroductionThe objective of this analysis is to evaluate the improvement in spinal pain with ixekizumab, placebo, and adalimumab based on objective...
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Tissue Engineered Mini-Cornea Model for Eye Irritation Test
Background :Eye irritation tests with animals have been conducted for a long time. However, the subjective decision to irritation, the...
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Bacteroides uniformis-induced perturbations in colonic microbiota and bile acid levels inhibit TH17 differentiation and ameliorate colitis developments
Inflammatory bowel disease (IBD) is associated with gut dysbiosis and can lead to colitis-associated malignancies. Bacteroides uniformis (Bu)...
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Organizing structural principles of the IL-17 ligand–receptor axis
The IL-17 family of cytokines and receptors have central roles in host defence against infection and development of inflammatory diseases
1 . The...
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The role of IL-17 in the pathogenesis and treatment of glioblastoma—an update on the state of the art and future perspectives
Glioblastoma (GBM) is the most common malignant brain tumor, which, despite significant progress made in the last years in the field of...
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Network pharmacological prediction of the mechanism of action of Shen-Zhu-Lian-Bai Decoction in the treatment of ulcerative colitis
The incidence of ulcerative colitis (UC) is on the rise globally. Shen-Zhu-Lian-Bai decoction (SZLBD) can relieve the clinical symptoms of UC. This...
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Interleukin-17 as a key player in neuroimmunometabolism
In mammals, interleukin (IL)-17 cytokines are produced by innate and adaptive lymphocytes. However, the IL-17 family has widespread expression...
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Role of IL-17 family cytokines in the progression of IPF from inflammation to fibrosis
Idiopathic pulmonary fibrosis (IPF) is a fatal chronic interstitial lung disease with no established treatment and is characterized by progressive...
