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1. Defective IGF-1 prohormone N-glycosylation and reduced IGF-1 receptor signaling activation in congenital disorders of glycosylation

   The insulin-like growth factor-1 (IGF-1) signaling pathway is crucial for the regulation of growth and development. The correct processing of the...

   Laura Di Patria, Giosuè Annibalini, ... Elena Barbieri in Cellular and Molecular Life Sciences

   Article Open access 24 February 2022
   

2. Recombinant IGF-1/BP3 protects against intestinal injury in a neonatal mouse NEC model

   Background

   Recombinant human IGF-1/binding protein-3 (rhIGF-1/BP3) is currently being tested in phase II clinical trials in premature infants to...

   **aocai Yan, Elizabeth Managlia, ... Isabelle G. De Plaen in Pediatric Research

   Article 28 February 2024
   

3. Dynamic Changes and Effects of H₂S, IGF-1, and GH in the Traumatic Brain Injury

   The aim of this study was to examine the expression changes of H ₂ S, IGF-1, and GH in traumatic brain injury (TBI) patients and to detect their...

   Zhen Zhang, **n Wu, ... Hongguang Chen in Biochemical Genetics

   Article 17 January 2024
   

4. Paradoxical effect of dopamine-agonists on IGF-1 in patients with prolactinoma: the role of weight

   Purpose

   An increase of IGF-1 has been reported during therapy with dopamine agonists (DA) for prolactinomas; in such cases a correct diagnosis is...

   S. Caprio, T. Pilli, ... M. G. Castagna in BMC Endocrine Disorders

   Article Open access 20 June 2024
   

5. CircUTRN24/miR-483-3p/IGF-1 Regulates Autophagy Mediated Liver Fibrosis in Biliary Atresia

   Biliary atresia (BA) is a rare neonatal cholestatic disease that presents with a marked bile duct reaction and rapid fibrotic development. Our...

   Dong Liu, Zhouguang Wu, ... Bin Wang in Molecular Biotechnology

   Article 27 June 2023
   

6. Expression of Salivary and Serum IGF-1 and IGFBP-3 in Individuals With Diabetes and Oral Cancer

   Aim

   To evaluate the expression of salivary and serum Insulin-like growth factor-1 (IGF-1) and Insulin-like growth factor binding protein-3 (IGFBP-3)...

   Rajendra Prabhu Abhinav, Catherine M. Bennett, ... Joanne Williams in Journal of Maxillofacial and Oral Surgery

   Article 24 May 2024
   

7. EHD1-dependent traffic of IGF-1 receptor to the cell surface is essential for Ewing sarcoma tumorigenesis and metastasis

   Overexpression of the EPS15 Homology Domain containing 1 (EHD1) protein has been linked to tumorigenesis but whether its core function as a regulator...

   Sukanya Chakraborty, Aaqib M. Bhat, ... Hamid Band in Communications Biology

   Article Open access 20 July 2023
   

8. Characterization of choroid plexus in the preterm rabbit pup following subcutaneous administration of recombinant human IGF-1/IGFBP-3

   Insulin-like growth factor-1 (IGF-1) is essential for normal brain development and regulates essential processes of vascular maturation and...

   Niklas Ortenlöf, Suvi Vallius, ... Magnus Gram in Fluids and Barriers of the CNS

   Article Open access 15 August 2023
   

9. GRP94 is an IGF-1R chaperone and regulates beta cell death in diabetes

   High workload-induced cellular stress can cause pancreatic islet β cell death and dysfunction, or β cell failure, a hallmark of type 2 diabetes...

   Do-Sung Kim, Lili Song, ... Hongjun Wang in Cell Death & Disease

   Article Open access 29 May 2024
   

10. Association between metabolic syndrome, insulin resistance, and IGF-1 in breast cancer survivors of DIANA-5 study

    Purpose

    Circulating insulin-like growth factor-1 (IGF-1) is positively associated with the risk of BC recurrence, and is more frequently dysregulated...

    Mauro De Santi, Giosuè Annibalini, ... Anna Villarini in Journal of Cancer Research and Clinical Oncology

    Article Open access 27 April 2023
    

11. A novel role of IGFBP5 in the migration, invasion and spheroids formation induced by IGF-I and insulin in MCF-7 breast cancer cells

    Purpose

    The insulin-like growth factor (IGF) system includes IGF-I, IGF-II insulin and their membrane receptors. IGF system also includes a family of...

    Karem Rodríguez-Rojas, Pedro Cortes-Reynosa, ... Eduardo Perez Salazar in Breast Cancer Research and Treatment

    Article Open access 19 June 2024
    

12. VAPB-mediated ER-targeting stabilizes IRS-1 signalosomes to regulate insulin/IGF signaling

    The scaffold protein IRS-1 is an essential node in insulin/IGF signaling. It has long been recognized that the stability of IRS-1 is dependent on its...

    **u Kui Gao, Zu Kang Sheng, ... Yi Ting Zhou in Cell Discovery

    Article Open access 01 August 2023
    

13. Inflammation induces stunting by lowering bone mass via GH/IGF-1 inhibition in very preterm infants

    Background

    Sustained systemic inflammatory response (SIR) was associated with poor postnatal growth in very preterm infants (VPI). We hypothesize that...

    Eduardo Cuestas, Macarena Hillman, ... Alina Rizzotti in Pediatric Research

    Article 20 March 2023
    

14. The relationship between morning blood pressure surge and serum IGF-1 level in acromegaly patients with hypertension

    Objective

    High levels of insulin-like growth factor 1 (IGF-1) in patients with acromegaly cause structural and functional changes specific to the...

    Fatih Necip Arici, Erdinc Gulumsek, ... Hilmi Erdem Sumbul in Irish Journal of Medical Science (1971 -)

    Article 27 July 2023
    

15. IGF Genes in Golden Pompano Trachinotus ovatus Larvae

    Insulin-like growth factors (IGFs) include IGF I and IGF II. IGF I is an essential regulator of cell division, differentiation, embryonic...

    **aomei Wang, Donghao Li, **angming Lin in Ontogenetic development of pompano Trachinotus ovatus

    Chapter 2022
    

16. Activation of NFAT by HGF and IGF-1 via ARF6 and its effector ASAP1 promotes uveal melanoma metastasis

    Preventing or effectively treating metastatic uveal melanoma (UM) is critical because it occurs in about half of patients and confers a very poor...

    Jackson R. Richards, Donghan Shin, ... Jae Hyuk Yoo in Oncogene

    Article 27 July 2023
    

17. Pregnancy associated plasma protein-A2 (PAPP-A2) and stanniocalcin-2 (STC2) but not PAPP-A are associated with circulating total IGF-1 in a human adult population

    The pappalysins pregnancy associated plasma protein-A (PAPP-A) and -A2 (PAPP-A2) act as proteinases of insulin-like growth factor-1 (IGF-1) binding...

    Katharina Nimptsch, Elif Ece Aydin, ... Tobias Pischon in Scientific Reports

    Article Open access 20 January 2024
    

18. The somatotroph pituitary gland function in high-aged multimorbid hospitalized patients with IGF-I deficiency

    Purpose

    It is unclear whether the age-related decline in the somatotropic axis stems from a reduced growth hormone (GH) production in the pituitary...

    Olivia Tausendfreund, Martin Bidlingmaier, ... Michael Drey in Pituitary

    Article Open access 31 May 2024

19. VEGF, IGF-1 and FGF-2 Serum Levels in Children and Adolescents with Autism Spectrum Disorder with and without Bipolar Disorder

    Purpose: To investigate serum levels of VEGF, IGF-1 and FGF-2, and relationships with several clinical characteristics in children and adolescents...

    Gokce Guldiken, Ali Karayagmurlu, ... Murat Coskun in Journal of Autism and Developmental Disorders

    Article 05 September 2023

20. Oral administration of ellagic acid mitigates perioperative neurocognitive disorders, hippocampal oxidative stress, and neuroinflammation in aged mice by restoring IGF-1 signaling

    This study investigates the potential of ellagic acid (EA), a phytochemical with antioxidant and anti-inflammatory properties, in managing...

    Fang Chen, Kai Lu, ... Fang Yue in Scientific Reports

    Article Open access 30 January 2024