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Biodistribution and immunity of adenovirus 5/35 and modified vaccinia Ankara vector vaccines against human immunodeficiency virus 1 clade C
Previously, we developed a chimeric adenovirus type 5 with type 35 fiber (Ad5/35), which has high tropism to dendritic cells and low hepatoxicity....
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Vector Tropism
Recombinant viruses expand the neurobiology toolbox and offer researchers an assortment of gene delivery options. Each type of virus varies in its...
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Medicinal Plants Against Human Adenovirus Type 1 Infections: Ethnopharmacology, Chemistry, and Clinical and Preclinical Studies
Adenoviruses are double-stranded DNA viruses responsible for respiratory infections, eye infections, epidemic conjunctivitis, and gastroenteritis in...
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SOCS3 inhibiting JAK-STAT pathway enhances oncolytic adenovirus efficacy by potentiating viral replication and T-cell activation
Oncolytic viruses (OVs) are emerging as a potentially useful treatment for malignancies due to the capabilities of direct oncolysis and immune...
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Surface Modification of Adenovirus Vector to Improve Immunogenicity and Tropism
Although adenovirus is a popular vector for delivering genes, there are several drawbacks that limit its effectiveness, including tropism and both...
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Identification of cross reactive T cell responses in adenovirus based COVID 19 vaccines
Vaccination has proven to be a valuable tool to combat SARS-CoV-2. However, reports of rare adverse reactions such as thrombosis/thrombocytopenia...
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Oncolytic adenovirus coding for shedding-resistant MICA enhances immune responses against tumors
Cancer immunotherapies strive to overcome tumor-induced immune suppression and activate antitumor immune responses. Although cytotoxic T lymphocytes...
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Oncolytic adenovirus encoding apolipoprotein A1 suppresses metastasis of triple-negative breast cancer in mice
BackgroundDysregulation of cholesterol metabolism is associated with the metastasis of triple-negative breast cancer (TNBC). Apolipoprotein A1...
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Vector-Mediated Cancer Gene Therapy Reduces Toxicity and Inhibition of Lung Carcinoma Growth in Nude Mice
Replication-competent oncolytic adenovirus (TOA2) gene therapy is a recently introduced anti-tumor treatment regimen with superior results. The...
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Preparation and identification of a single domain antibody specific for adenovirus vectors and its application to the immunoaffinity purification of adenoviruses
Adenovirus belongs to the family of Adenoviridae. As a vaccine carrier, it has high safety and stimulates the body to produce cellular immunity and...
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Molecular epidemiology analysis of fowl adenovirus detected from apparently healthy birds in eastern China
BackgroundFowl adenovirus is of major concern to the poultry industry worldwidely. In order to monitor the prevalent status of Fowl adenovirus in...
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Plasma Metabonomics of Human Adenovirus-infected Patients with Pneumonia and Upper Respiratory Tract Infection
ObjectiveHuman adenovirus (HAdV) infection is common and can develop to serious conditions with high mortality, yet the mechanism of HAdV infection...
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Effects of pre-existing anti-adenovirus antibodies on transgene expression levels and therapeutic efficacies of arming oncolytic adenovirus
Oncolytic adenoviruses (OAds), most of which are based on species C human adenovirus serotype 5 (Ad5) (OAd5), have recently received much attention...
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Variational autoencoder for design of synthetic viral vector serotypes
Recent, rapid advances in deep generative models for protein design have focused on small proteins with lots of data. Such models perform poorly on...
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Targeted shock-and-kill HIV-1 gene therapy approach combining CRISPR activation, suicide gene tBid and retargeted adenovirus delivery
Infections with the human immunodeficiency virus type 1 (HIV-1) are incurable due the long-lasting, latent viral reservoir. The shock-and-kill cure...
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Genomic Evolution and Recombination Dynamics of Human Adenovirus D Species: Insights from Comprehensive Bioinformatic Analysis
Human adenoviruses (HAdVs) can infect various epithelial mucosal cells, ultimately causing different symptoms in infected organ systems. With more...
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A selective cytotoxic adenovirus vector for concentration of pluripotent stem cells in human pluripotent stem cell-derived neural progenitor cells
Highly sensitive detection of residual undifferentiated pluripotent stem cells is essential for the quality and safety of cell-processed therapeutic...
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Both chimpanzee adenovirus-vectored and DNA vaccines induced long-term immunity against Nipah virus infection
Nipah virus (NiV) is a highly lethal zoonotic paramyxovirus that poses a severe threat to humans due to its high morbidity and the lack of viable...
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Revolutionizing Veterinary Health with Viral Vector-Based Vaccines
Vaccines signify one of the economical and reasonable means to prevent and eradicate the important infectious diseases. Conventional vaccines like...
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Ixovex-1, a novel oncolytic E1B-mutated adenovirus
There is a great demand for improved oncolytic viruses that selectively replicate within cancer cells while sparing normal cells. Here, we describe a...
