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SPRING licenses S1P-mediated cleavage of SREBP2 by displacing an inhibitory pro-domain
Site-one protease (S1P) conducts the first of two cleavage events in the Golgi to activate Sterol regulatory element binding proteins (SREBPs) and...
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MAGinator enables accurate profiling of de novo MAGs with strain-level phylogenies
Metagenomic sequencing has provided great advantages in the characterisation of microbiomes, but currently available analysis tools lack the ability...
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The incidence of diabetes mellitus and its determining factors in a Kurdish population: insights from a cohort study in western Iran
Diabetes mellitus (DM) is among the most widespread non-communicable diseases and poses a substantial global health challenge. The aim of this study...
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Employing antagonistic C-X-C motif chemokine receptor 4 antagonistic peptide functionalized NaGdF4 nanodots for magnetic resonance imaging-guided biotherapy of breast cancer
C-X-C motif chemokine receptor 4 (CXCR4) is a promising therapeutic target of breast cancer because it is overexpressed on cell surface of all...
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Evolution and subfunctionalization of CIPK6 homologous genes in regulating cotton drought resistance
The occurrence of whole-genome duplication or polyploidy may promote plant adaptability to harsh environments. Here, we clarify the evolutionary...
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Elevated SLC3A2 associated with poor prognosis and enhanced malignancy in gliomas
The role of SLC3A2, a gene implicated in disulfidptosis, has not been characterized in gliomas. This study aims to clarify the prognostic value of...
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Proteomic profiling of regenerated urinary bladder tissue in a non-human primate augmentation model
Urinary bladder dysfunction can be caused by environmental, genetic, and developmental insults. Depending upon insult severity, the bladder may lose...
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Numerical simulation on transient electromagnetic response of separation layer water in coal seam roof
Mining stress induces deformation and fracture of the overlaying rock, which will result in water filling the separation layer if the aquifer finds...
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Neural network-based algorithm for door handle recognition using RGBD cameras
The ability to recognize and interact with a variety of doorknob designs is an important component on the path to true robot adaptability, allowing...
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Noninvasive, label-free image approaches to predict multimodal molecular markers in pluripotency assessment
Manufacturing regenerative medicine requires continuous monitoring of pluripotent cell culture and quality assessment while eliminating cell...
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Topologically controlled synthesis of active colloidal bipeds
Topological growth control allows to produce a narrow distribution of outgrown colloidal rods with defined and adjustable length. We use an external...
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An efficient, reliable and valid assessment for affective states during online learning
The current study aims to develop an efficient, reliable and valid assessment, the affective states for online learning scale (ASOLS), for measuring...
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Prediction of frequency response of sub-frame bushing and study of high-order fractional derivative viscoelastic model
This paper presents experimental and dynamic modeling research on the rubber bushings of the rear sub-frame. The Particle Swarm Optimization...
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Restoring private autism dataset from sanitized database using an optimized key produced from enhanced combined PSO-GWO framework
The timely identification of autism spectrum disorder (ASD) in children is imperative to prevent potential challenges as they grow. When sharing data...
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Recovery effect of self‐myofascial release treatment using different type of a foam rollers
Among athletes, foam rolling is popular technique of myofascial release aimed to support recovery processes and counteract delayed onset muscle...
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A hierarchical optimization approach to maximize hosting capacity for electric vehicles and renewable energy sources through demand response and transmission expansion planning
Within the scope of sustainable development, integrating electric vehicles (EVs) and renewable energy sources (RESs) into power grids offers a number...
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Ionic liquid based surfactant-free microemulsion as a new protocol for preparation of visible light active poly(methyl methacrylate)/TiO2 nanocomposite
The practical application of sensitized TiO 2 nanocomposites is very satisfying due to their high photon utilization in visible light, simple recovery...
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Heterogeneity in lung macrophage control of Mycobacterium tuberculosis is modulated by T cells
Following Mycobacterium tuberculosis infection, alveolar macrophages are initially infected but ineffectively restrict bacterial replication. The...
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Lithium-ion battery components are at the nexus of sustainable energy and environmental release of per- and polyfluoroalkyl substances
Lithium-ion batteries (LiBs) are used globally as a key component of clean and sustainable energy infrastructure, and emerging LiB technologies have...
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B-cell hub genes play a cardiovascular pathogenic role of in childhood obesity and Kawasaki disease as revealed by transcriptomics-based analyses
The study aims to explore the central genes that Kawasaki disease (KD) and Obesity (OB) may jointly contribute to coronary artery disease....
