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PEGylation of Proteins as Tailored Chemistry for Optimized Bioconjugates
The high potential of peptides and proteins as therapeutic agents has not been fully exploited because of their common shortcomings: the only...
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Polymer Therapeutics for Cancer: Current Status and Future Challenges
Drug delivery systems for cancer therapeutics have revolutionized medicine. Delivery systems have improved the efficacy and reduced the toxicity of...
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Polypeptide and Polypeptide Hybrid Copolymer Synthesis via NCA Polymerization
This article summarizes recent developments in the synthesis of polypeptides and hybrid peptide copolymers. Traditional methods used to polymerize...
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Gene Delivery Using Polymer Therapeutics
The use of polymers as synthetic non-viral carriers for introducing nucleic acids into cells appears very appealing. Polymers can be generated in...
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Nanostructured Devices Based on Block Copolymer Assemblies for Drug Delivery: Designing Structures for Enhanced Drug Function
Block copolymers spontaneously assemble into nanoscaled polymeric micelles, which have significant potential as drug carriers. Following much work...
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Polymer Therapeutics: Polymers as Drugs, Drug and Protein Conjugates and Gene Delivery Systems: Past, Present and Future Opportunities
As the 21st century begins we are witnessing a paradigm shift in medical practice. Whereas the use of polymers in biomedical materials applications...
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Solution Properties of Polypeptide-based Copolymers
The aggregation behaviour of biomimetic polypeptide hybrid copolymers and copolypeptides is here reviewed with a particular eye on the occurrence...
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The Broad Spectrum of Responses to Oxidative Stress in Proliferating Cells
Proliferating mammalian cells exhibit a broad spectrum of responses to oxidative stress, depending on the stress level encountered. Very low levels...
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Low Molecular Weight Antioxidants
Low molecular weight antioxidants are an important part of the antioxidative defense mechanisms of cells and organisms. This chapter gives a short...
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Environmental Oxidative Stress – Environmental Sources of ROS
Environmental factors are known sources for oxidative stress. In consequence of the numerous influences that define our environment, environmental...
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Endogenous Oxidant-Generating Systems
Although organisms respiring air oxygen use their energy sources in an optimal way they are threatened by the compulsory formation of reactive oxygen...
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Recent Advances in Vinylogous Aldol Reactions and Their Applications in the Syntheses of Natural Products
The synthesis of complex natural products still remains as the bottleneck for the biological evaluation of such compounds. In contrast to the...
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Enantioselective Synthesis of C(8)-Hydroxylated Lignans—Early Approaches and Recent Advances
α-Hydroxylated lignans, dimers of phenylpropene with important biological properties, have been enantioselectively prepared following different...
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Glutathione
Glutathione is the most abundant non-protein thiol in cells. It is a tripeptide with two important structural features: the thiol group and the...
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Modulation of Cellular Signaling Processes by Reactive Oxygen Species
Exposure of cells to reactive oxygen species (ROS) may result not only in cell death by excessive oxidation of biomolecules but also cause the...
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Recent Progress in the Total Synthesis of Dolabellane and Dolastane Diterpenes
The isolation, structure and total synthesis of members of four classes of diterpenes has been summarized. Dolabellanes, neodolabellanes, dolastanes...
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Marine Natural Products from Pseudopterogorgia elisabethae: Structures, Biosynthesis, Pharmacology, and Total Synthesis
In the late 1990s, the Caribbean octocoral Pseudopterogorgia elisabethae became the target of extensive chemical investigations leading to the...
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Domino Dendrimers
Domino dendrimers have recently been developed and introduced as a potential platform for a single triggered multi-prodrug. Surprisingly, three...
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Molecular-Scale Studies on Biopolymers Using Atomic Force Microscopy
The atomic force microscope (AFM) is capable of acquiring a range of structural and physicochemical information on a wide range of biopolymers. The...
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Polymer Genomics
Biological activities of biocompatible synthetic polymers used in drug delivery, gene delivery, vaccine development or biomaterial surface...