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Benmelstobart, anlotinib and chemotherapy in extensive-stage small-cell lung cancer: a randomized phase 3 trial
Immunochemotherapy is the first-line standard for extensive-stage small-cell lung cancer (ES-SCLC). Combining the regimen with anti-angiogenesis may...
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Adoptive transfer of personalized neoantigen-reactive TCR-transduced T cells in metastatic colorectal cancer: phase 2 trial interim results
Adoptive cell transfer (ACT) with neoantigen-reactive T lymphocytes can mediate cancer regression. Here we isolated unique, personalized,...
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Emotion-focused therapy for women with premenstrual dysphoric disorder: a randomized clinical controlled trial
BackgroundPremenstrual dysphoric disorder (PMDD) is a debilitating condition, affecting women of reproductive age. It is characterized by severe...
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The spectrum of anti-GQ1B antibody syndrome: beyond Miller Fisher syndrome and Bickerstaff brainstem encephalitis
IntroductionSince the initial identification of Miller Fisher syndrome (MFS) and Bickerstaff brainstem encephalitis (BBE),significant milestones have...
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Systematic Review and Meta-Analysis of the Diagnostic Accuracy of a Graded Gait and Truncal Instability Rating in Acutely Dizzy and Ataxic Patients
BackgroundIn patients presenting with acute prolonged vertigo and/or gait imbalance, the HINTS [Head-Impulse, Nystagmus, Test-of-Skew] are very...
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Paclitaxel in colon cancer management: from conventional chemotherapy to advanced nanocarrier delivery systems
Paclitaxel, a potent chemotherapeutic agent derived from the bark of the Pacific yew tree, has demonstrated significant efficacy in the treatment of...
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Attention-based cross-frequency graph convolutional network for driver fatigue estimation
Fatigue driving significantly contributes to global vehicle accidents and fatalities, making driver fatigue level estimation crucial....
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Regulation of MicroRNAs After Spinal Cord Injury in Adult Zebrafish
Spinal cord injury (SCI) is a central nerve injury that often leads to loss of motor and sensory functions at or below the level of the injury....
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The Association Between Autism Symptomatology and Adaptive Functioning Over Six Months: Findings from the Pilot Phase of the PARC Study
PurposeIn the context of developmental trajectories, the association between adaptive functioning and core autism symptomatology remains unclear. The...
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Patterns of Pregabalin Users from Substance Abuse Treatment Facilities: Results from the French OPPIDUM Program from 2008 to 2022
IntroductionIn recent years, pregabalin has received growing attention due to its abuse liability. The aim of this study was to further characterize...
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Heterogeneity in choice models of addiction: the role of context
RationaleTheories of addiction guide scientific progress, funding priorities, and policy development and ultimately shape how people experiencing or...
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Antibiotic use and risk of autism spectrum disorder and attention-deficit/hyperactivity disorder: a population-based cohort study
BackgroundThe gut microbiota is believed to influence neurodevelopment through the gut–brain axis, but prior studies have shown inconsistent results...
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Precision public health in the era of genomics and big data
Precision public health (PPH) considers the interplay between genetics, lifestyle and the environment to improve disease prevention, diagnosis and...
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Inequality in high-cost borrowing and unemployment insurance generosity in US states during the COVID-19 pandemic
US consumers may turn to the private market for credit when income and government benefits fall short. The most vulnerable consumers have access only...
