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Neurorights, Mental Privacy, and Mind Reading
A pressing worry in the ongoing neurorights debate is the language used to advocate for newly proposed rights. This paper addresses this concern by...
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Identification of retinal oligomeric, citrullinated, and other tau isoforms in early and advanced AD and relations to disease status
This study investigates various pathological tau isoforms in the retina of individuals with early and advanced Alzheimer’s disease (AD), exploring...
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Flexible multitask computation in recurrent networks utilizes shared dynamical motifs
Flexible computation is a hallmark of intelligent behavior. However, little is known about how neural networks contextually reconfigure for different...
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Brain Networks, Neurotransmitters and Psychedelics: Towards a Neurochemistry of Self-Awareness
Purpose of ReviewSelf-awareness can be defined as the capacity of becoming the object of one’s own awareness and, increasingly, it has been the...
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Modeling kinematic variability reveals displacement and velocity based dual control of saccadic eye movements
Noise is a ubiquitous component of motor systems that leads to behavioral variability of all types of movements. Nonetheless, systems-based models...
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Protective and curative effects of unconjugated bilirubin on gene expression of LOX-1 and iNOS in the heart of rats receiving high-fat diet and low dose streptozotocin: a histomorphometric approach
BackgroundAtherosclerosis is a chronic inflammatory condition affecting the large arteries and is a major cause of cardiovascular diseases (CVDs)...
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Investigation of the Circular Transcriptome in Alzheimer’s Disease Brain
Circular RNAs (circRNAs) are a subclass of non-coding RNAs which have demonstrated potential as biomarkers for Alzheimer’s disease (AD). In this...
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A Calculated Risk: Evaluation of QTc Drug–Drug Interaction (DDI) Clinical Decision Support (CDS) Alerts and Performance of the Tisdale Risk Score Calculator
IntroductionA risk factor for a potentially fatal ventricular arrhythmia Torsade de Pointes is a prolongation in the heart rate-corrected QT interval...
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Serum dysregulation of serine and glycine metabolism as predictive biomarker for cognitive decline in frail elderly subjects
Frailty is a common age-related clinical syndrome characterized by a decline in the function of multiple organ systems, increased vulnerability to...
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Distribution Clearance: Significance and Underlying Mechanisms
PurposeEvaluation of distribution kinetics is a neglected aspect of pharmacokinetics. This study examines the utility of the model-independent...
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Resolution of anti-LGI1-associated autoimmune encephalitis in a patient after treatment with efgartigimod
BackgroundAnti leucine-rich, glioma inactivated 1 (LGI1) antibody-associated autoimmune encephalitis (AE) is the second most common AE, where the...
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Optimal Significance Levels and Sample Sizes for Signal Detection Methods Based on Non-constant Hazards
Background and ObjectivesStatistical methods for signal detection of adverse drug reactions (ADRs) in electronic health records (EHRs) need...
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Formulation and Antimycotic Evaluation of Colloidal Itraconazole-Loaded Metered Dose Sprays for Treating Superficial Mycoses
Commercial topical formulations containing itraconazole (poorly water soluble), for mycotic infections, have poor penetration to infection sites...
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Association Between County-Level Social Vulnerability and Deprivation with Opioid Dispensing Rates in the United States
Policymakers planning to implement evidence-based programs (e.g., harm reduction therapy) to address opioid-related overdoses and deaths may benefit...
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Contextual Triggers and Tic Severity Across Life Periods: A Retrospective Analysis in Adults with Tic Disorders
In tic disorders (TD), tic expression varies across the lifespan and as a function of contextual factors. This study explored connections between tic...
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Pharmacokinetics of piperaquine and its association with intermittent malaria preventive therapy outcomes during pregnancy
BackgroundDihydroartemisinin-piperaquine (DHP) recently showed superior effectiveness over sulfadoxine-pyrimethamine for malaria intermittent...
