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Map** alternative splicing events in colorectal cancer
Although aberrant splicing events of genes are closely related to the development and progression of colorectal cancer (CRC), the map** of abnormal...
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Introduction: Regulatory processes, an emerging feature in intracellular membrane traffic
The subject of this volume is the molecular mechanism of the intracellular membrane trafficking, a central eukaryotic cell biological process. In the...
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Functions of Rab GTPases in organelle biogenesis
Rab GTPases regulate diverse aspects of the biogenesis of secretory and endocytic organelles. The conformational changes that accompany GTP binding...
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Charge Transport and Catalysis by Molecules Confined in Polymeric Materialsand Application to Future Nanodevices for Energy Conversion
Polymeric materials confining functional molecules are one of the most promising materials for designing nanodevices for energy conversion, e.g.,...
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White matter microstructural integrity as a key to effective propagation of gamma entrainment in humans
Gamma entrainment through sensory stimulation has the potential to reduce the pathology of Alzheimer’s disease in mouse models. However, clinical...
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Gene therapy by virus-like self-spooling toroidal DNA condensates for revascularization of hindlimb ischemia
Peripheral arterial diseases (PAD) have been reported to be the leading cause for limb amputations, and the current therapeutic strategies including...
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Advanced Targeting Strategies for Murine Retroviral and Adeno-associated Viral Vectors
Targeted gene delivery involves broadening viral tropism to infect previously nonpermissive cells, replacing viral tropism to infect a target cell...
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Nonviral Delivery of Cancer Genetic Vaccines
The potential use of genetic vaccines to address numerous diseases including cancer is promising, but currently unrealized. Here, we review...
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Production and Formulation of Adenovirus Vectors
Adenovirus vectors have attracted considerable interest over the past decade, with ongoing clinical development programs for applications ranging...
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Molecular Conjugates
Molecular conjugates are nanometer-sized entities consisting of synthetic materials (lipids, polycations, targeting agents, and so on) and nucleic...
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Regulation of SNARE assembly by protein phosphorylation
Protein phosphorylation is emerging as an important regulatory mechanism that controls the secretory pathway. It enables coupling between the...
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Molecular mechanisms in clathrin-mediated membrane budding
Clathrin-coated vesicles (CCVs) form at the plasma membrane where they select cargo for endocytic entry into cells. CCVs also form at the trans-Golgi...
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Tethering proteins in membrane traffic
In eukaryotic cells, protein secretion and the transport of materials between membrane-bounded organelles require efficient and accurate delivery of...
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Regulation of exocytotic events by centrosome-analogous structures
Centrosomes, spindle pole bodies, and related structures, generally termed microtubule organising centres (MTOCs; Pickett-Heaps 1969), are best...
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Spiro Compounds for Organic Electroluminescence and Related Applications
A comprehensive review about functional spiro compounds, their synthesis, physical properties and applications in optoelectronic devices is given.
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Polyphenylene-type Emissive Materials: Poly(para-phenylene)s,Polyfluorenes, and Ladder Polymers
This ‘chapter’ reviews the synthesis of the various classes of polyphenylene-based materials that have been investigated as active materials in...
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Conducting Polymer Nanomaterials and Their Applications
A paradigm shift takes place in the fabrication of conducting polymers from bulky features with microsize to ultrafine features with nanometer range....
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Adeno-associated Virus as a Gene Therapy Vector: Vector Development, Production and Clinical Applications
Adeno-associated virus (AAV) has emerged as an attractive vector for gene therapy. AAV vectors have successfully been utilized to promote...