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Rapid evolution of promoters from germline-specifically expressed genes including transposon silencing factors
BackgroundThe piRNA pathway in animal gonads functions as an ‘RNA-based immune system’, serving to silence transposable elements and prevent...
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Identification, validation and candidate gene analysis of major QTL for Supernumerary spikelets in wheat
BackgroundThe number of spikelets per spike is a key trait that affects the yield of bread wheat ( Triticum aestivum L.). Identification of the QTL...
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Exploring the genetic basis of anthracnose resistance in Ethiopian sorghum through a genome-wide association study
BackgroundSorghum anthracnose is a major disease that hampers the productivity of the crop globally. The disease is caused by the hemibiotrophic...
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Integrated proteomic and metabolomic profiling reveals novel insights on the inflammation and immune response in HFpEF
BackgroundThe precise mechanisms leading to the development of heart failure with preserved ejection fraction (HFpEF) remain incompletely defined. In...
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Four novel mutations identified in the COL4A3, COL4A4 and COL4A5 genes in 10 families with Alport syndrome
BackgroundAlport syndrome (AS) is an inherited nephropathy caused by mutations in the type IV collagen genes. It is clinically characterized by...
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Dietary restriction promote sperm remodeling in aged roosters based on transcriptome analysis
BackgroundThe breeder rooster has played a pivotal role in poultry production by providing high-quality semen. Typically, fertility peaks between 30...
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Benchmarking short and long read polishing tools for nanopore assemblies: achieving near-perfect genomes for outbreak isolates
BackgroundOxford Nanopore provides high throughput sequencing platforms able to reconstruct complete bacterial genomes with 99.95% accuracy. However,...
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A case of Ph+ acute lymphoblastic leukemia and EGFR mutant lung adenocarcinoma synchronous overlap: may one TKI drug solve two diseases?
BackgroundPhiladelphia chromosome positive (Ph + ) acute lymphoblastic leukemia (ALL) refers to ALL patients with t(9;22) cytogenetic abnormalities,...
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Transcriptomic responses of Mediterranean sponges upon encounter with symbiont microbial consortia
BackgroundSponges (phylum Porifera) constantly interact with microbes. They graze on microbes from the water column by filter-feeding and they harbor...
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New advances in drug development for metabolic dysfunction-associated diseases and alcohol-associated liver disease
Metabolic disorders are currently threatening public health worldwide. Discovering new targets and develo** promising drugs will reduce the global...
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Targeting protein interaction networks in mitochondrial dynamics for neurodegenerative diseases
Mitochondria, the powerhouse of eukaryotic cells, are the central organelle controlling energy metabolism and apoptosis. Based on metabolic needs,...
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A single-sample workflow for joint metabolomic and proteomic analysis of clinical specimens
Understanding the interplay of the proteome and the metabolome helps to understand cellular regulation and response. To enable robust inferences from...
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Comparative Functional Characterization of nst1, nst2, and nst3 in Arabidopsis thaliana Uncovers Previously Unknown Functions in Diverse Developmental Pathways Beyond Secondary Wall Formation
The regulation of secondary cell wall formation in Arabidopsis thaliana has been extensively studied with NST1 , NST2 , and NST3 playing key roles in...
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Proteome-scale tagging and functional screening in mammalian cells by ORFtag
The systematic determination of protein function is a key goal of modern biology, but remains challenging with current approaches. Here we present...
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Microsecond time-resolved X-ray scattering by utilizing MHz repetition rate at second-generation XFELs
Detecting microsecond structural perturbations in biomolecules has wide relevance in biology, chemistry and medicine. Here we show how MHz repetition...
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Proteome profiling of cutaneous leishmaniasis lesions due to dermotropic Leishmania donovani in Sri Lanka
BackgroundCharacterization of the host response in cutaneous leishmaniasis (CL) through proteome profiling has gained limited insights into...
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Unraveling metabolic pathways and key genes in Alzheimer’s, type 2 diabetes, and estrogen dysregulation among aging women: a systems biology approach
BackgroundAlzheimer’s disease (AD) and Type 2 Diabetes Mellitus (T2DM) present significant global health challenges, particularly affecting aging...
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Functional and evolutionary comparative analysis of the DIR gene family in Nicotiana tabacum L. and Solanum tuberosum L.
BackgroundThe dirigent ( DIR ) genes encode proteins that act as crucial regulators of plant lignin biosynthesis. In Solanaceae species, members of...
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Genetic evidence for causal association between migraine and dementia: a mendelian randomization study
BackgroundThere is an association between migraine and dementia, however, their causal relationship remains unclear. This study employed...
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Population genetic structure of Culex tritaeniorhynchus in different types of climatic zones in China
BackgroundCulex tritaeniorhynchus is widely distributed in China, from Hainan Island in the south to Heilongjiang in the north, covering tropical,...
