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Diacerein mitigates endocrine and cardio-metabolic disruptions in experimental PCOS mice model by modulating AdipoR1/ PON 1
BackgroundThis study aimed to explore the impact of Diacerein (DIC) on endocrine and cardio-metabolic changes in polycystic ovarian syndrome (PCOS)...
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Dried fruit intake and lower risk of type 2 diabetes: a two-sample mendelian randomization study
BackgroundPrevious studies have shown controversy about whether dried fruit intake is associated with type 2 diabetes. This study aimed to examine...
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The obesity-related mutation gene on nonalcoholic fatty liver disease
The prevalence of overweight and obesity is increasing, leading to metabolic-associated fatty liver disease (MAFLD) characterized by excessive...
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Molecular circadian clock disruption in the leukocytes of individuals with type 2 diabetes and overweight, and its relationship with leukocyte–endothelial interactions
Aims/hypothesisAlterations in circadian rhythms increase the likelihood of develo** type 2 diabetes and CVD. Circadian rhythms are controlled by...
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Review on the role of hypothalamic astrocytes in the neuroendocrine control of metabolism
Astrocytes are the most numerous type of glial cells found in the nervous system. They regulate energy homeostasis in collaboration with the neuronal...
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Relationship between non-alcoholic fatty liver and progressive fibrosis and serum 25-hydroxy vitamin D in patients with type 2 diabetes mellitus
ObjectiveWe aimed to analyze the relationship between non-alcoholic fatty liver and progressive fibrosis and serum 25-hydroxy vitamin D (25(OH)D) in...
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Skin carotenoid scores and metabolic syndrome in a general Japanese population: the Hisayama study
BackgroundHigher vegetable intake is being promoted as an initiative to prevent lifestyle-related diseases. Carotenoids are yellow or red pigment...
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Efficacy of tibial cortex transverse transport in treating diabetic foot ulcer and its effect on serum omentin-1 and irisin levels
ObjectiveDiabetic foot ulcer (DFU) is a common and debilitating complication of diabetes that is associated with an increased risk of lower-limb...
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The association between the neutrophil-to-lymphocyte ratio and type 2 diabetes mellitus: a cross-sectional study
BackgroundType 2 diabetes mellitus (T2DM) is a prevalent chronic disease often accompanied by low-grade inflammation. Recently, the...
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Effect of switching from twice-daily basal insulin to once-daily insulin glargine 300 U/mL (Gla-300) in Brazilian people with type 1 diabetes
BackgroundLow adherence to the number of insulin injections and glycemic variability are among the challenges of insulin therapy in type 1 diabetes...
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Association between bone turnover markers, bone mineral density, and serum osteoglycine in middle-aged men with Type 2 Diabetes mellitus
BackgroundPatients with Type 2 diabetes mellitus (T2DM) have decreased bone health. We aimed to investigate serum levels of bone turnover markers...
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The correlation between hepatic controlled attenuation parameter (CAP) value and insulin resistance (IR) was stronger than that between body mass index, visceral fat area and IR
BackgroundHepatic controlled attenuation parameter (CAP) is a novel marker for quantifying hepatic fat accumulation. Insulin resistance (IR) plays a...
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Challenges in the management of patients with HNF1B MODY and multisystem manifestations: the cases of two adolescent boys
IntroductionHepatocyte nuclear factor-1 beta ( HNF1B ) encodes a homeodomain-containing transcription factor, which is expressed early in...
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Preparation of a monoclonal antibody against recombinant LSDV034 protein and its application in detecting lumpy skin disease virus through a competitive enzyme-linked immunosorbent assay (cELISA)
Lumpy skin disease (LSD) is a highly contagious disease caused by lumpy skin disease virus (LSDV) in bovines. Rapid and accurate diagnosis is very...
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Metabolomic and lipidomic profiling of the spinal cord in type 2 diabetes mellitus rats with painful neuropathy
In this paper we investigated lipid and metabolite changes in diabetic neuropathy, using untargeted lipidomics and metabolomics analyses of the...
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INFLA score: a novel inflammatory marker for assessing cardiometabolic disease risk in obese individuals
BackgroundThe low-grade inflammation score (INFLA-score) is a composite index that assesses chronic inflammatory status using multiple inflammatory...
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Sex- and age-specific associations of serum essential elements with diabetes among the Chinese adults: a community-based cross-sectional study
BackgroundAlthough several studies have found the relationship between essential elements and diabetes, the studies about the association of...
