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Cytogenomic description of a Mexican cohort with differences in sex development
BackgroundDifferences in Sex Development (DSD) is a heterogeneous group of congenital alterations that affect inner and/or outer primary sex...
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The association between waist-to-hip ratio (WHR) with diabetes in the PERSIAN Guilan cohort study population
BackgroundWaist circumference (WC), or waist-to-hip ratio (WHR), potentially offers a more accurate reflection of intra-abdominal fat accumulation...
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Consumer wearable devices for evaluation of heart rate control using digoxin versus beta-blockers: the RATE-AF randomized trial
Consumer-grade wearable technology has the potential to support clinical research and patient management. Here, we report results from the RATE-AF...
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Exploring the electronic structure of knotted proteins: the case of two ornithine transcarbamylase family
Context:Geometrical knots are rare structural arrangements in proteins in which the polypeptide chain ties itself into a knot, which is very...
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Design and Validation of Novel Potential Antiperspirant Peptides Blocking M3-Gαq Sweat Signaling Cascade
Sweat production is vital for human survival as its evaporation eases heat dissipation. Nevertheless, excessive perspiration or hyperhidrosis causes...
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Preclinical evaluation of CXCR4 peptides for targeted radionuclide therapy in glioblastoma
BackgroundGlioblastoma (GBM), is the most fatal form of brain cancer, with a high tendency for recurrence despite combined treatments including...
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Acute effects of dynamic stretching exercises on vertical jump performance and flexibility
PurposeThis study was conducted to examine the acute effects of dynamic stretching exercises (DSE) on vertical jump height (VJH), muscle strength...
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Predictors of parent self-monitoring patterns in a family-based behavioral weight loss treatment program
ObjectiveSelf-monitoring dietary intake is a critical component of family-based intensive health behavior and lifestyle treatment for pediatric...
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Clinical effects of teriparatide, abaloparatide, and romosozumab in postmenopausal osteoporosis
In the management of osteoporosis, anti-resorptive agents serve as a primary therapeutic approach. However, in cases where individuals exhibit an...
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Early changes of microRNAs in blood one month after bariatric surgery
BackgroundChanges in microRNAs (miRNAs) are relevant to bariatric surgery and its comorbidities. The characteristics of changes in miRNAs of the...
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Thyroid complications after hemopoietic stem cell transplantation in children and adolescents
PurposeTo evaluate the prevalence of thyroid dysfunction and its association with possible contributing factors related to diagnosis and treatment in...
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Characterization of 13 Novel Genetic Variants in Genes Associated with Epilepsy: Implications for Targeted Therapeutic Strategies
BackgroundChildhood epilepsies are caused by heterogeneous underlying disorders where approximately 40% of the origins of epilepsy can be attributed...
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Characterization of obesity-related diseases and inflammation using single cell immunophenoty** in two different diet-induced obesity models
BackgroundObesity is a growing problem worldwide and a major risk factor for many chronic diseases. The accumulation of adipose tissue leads to the...
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Identifying early symptoms associated with a diagnosis of childhood, adolescent and young adult cancers: a population-based nested case-control study
BackgroundChildhood, teenage and young adult (CTYA, 0–24 years) cancers are rare and diverse, making timely diagnosis challenging. We aim to explore...
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Imaging-based body fat distribution and diabetic retinopathy in general US population with diabetes: an NHANES analysis (2003–2006 and 2011–2018)
BackgroundLimited studies have investigated the correlation between fat distribution and the risk of diabetic retinopathy (DR) in the general...
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Effects of exercise mimetics as putative therapeutics on brain health, aging, and neurodegenerative diseases
There is growing evidence that an active lifestyle can benefit brain health, delay the onset of neurodegenerative diseases and aging, and improve...
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Ultra-processed food consumption and risk of diabetes: results from a population-based prospective cohort
Aims/hypothesisUnderstanding the impact of the overall construct of ultra-processed foods on diabetes risk can inform dietary approaches to diabetes...
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Neuroprotective and vasoprotective effects of herb pair of Zhiqiao-Danggui in ischemic stroke uncovered by LC-MS/MS-based metabolomics approach
Ischemic stroke is the most important cause of disability and death worldwide, but current treatments remain limited. Traditional Chinese medicine...
