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Multi-omics Investigations in Endocrine Systems and Their Clinical Implications
Innovative techniques such as the “omics” can be a powerful tool for the understanding of intracellular pathways involved in homeostasis maintenance...
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Proteomics and Metabolomics in Congenital Zika Syndrome: A Review of Molecular Insights and Biomarker Discovery
Zika virus (ZIKV) infection can be transmitted vertically, leading to the development of congenital Zika syndrome (CZS) in infected fetuses. During...
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Kidney Disease and Proteomics: A Recent Overview of a Useful Tool for Improving Early Diagnosis
Kidney disease is a critical and potentially life-threatening degenerative condition that poses a significant global public health challenge due to...
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Applications of Proteomics in Probiotics Having Anticancer and Chemopreventive Properties
Proteomics has grown in importance in molecular sciences because it gives vital information on protein identification, expression levels, and...
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Omics to Unveil Diabetes Mellitus Pathogenesis and Biomarkers: Focus on Proteomics, Lipidomics, and Metabolomics
Diabetes mellitus (DM) is a chronic metabolic disorder characterized by elevated blood sugar levels, resulting from either body’s inability to...
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Mass Spectrometry-Based Characterization of Protein Aggregates in Tissues and Biofluids
Protein aggregation is a common mechanism in multiple neurodegenerative and heart diseases and the accumulation of proteins in aggregates is toxic to...
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Proteomic-Based Studies on Memory Formation in Normal and Neurodegenerative Disease-Affected Brains
A critical aspect of cognition is the ability to acquire, consolidate, and evoke memories, which is considerably impaired by neurodegenerative...
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Triazole Antifungal Quantification for Therapeutic Drug Monitoring in Serum by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS): Posaconazole, Voriconazole, Itraconazole, and Hydroxyitraconazole
Antifungal therapy with triazole drugs including posaconazole, voriconazole, itraconazole, and its active metabolite hydroxyitraconazole is routinely...
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Determination of Treosulfan and Fludarabine in Plasma by Turbulent Flow Liquid Chromatography-Tandem Mass Spectrometry (TFLC-MS/MS)
Treosulfan is a structural analog of the alkylating agent busulfan which has been shown in clinical trials to exhibit comparable myeloablative...
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Quantification of Olanzapine by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Olanzapine (Zyprexa™) is indicated for the treatment of schizophrenia and bipolar disorder. Olanzapine is metabolized to inactive metabolites;...
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Quantitative Analysis of Buprenorphine, Norbuprenorphine, and Their Glucuronide Metabolites in Human Urine
We present a quantitative clinical LC-MS/MS assay for the simultaneous analysis of buprenorphine, norbuprenorphine, and their glucuronide metabolites...
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High-Throughput Quantitative LC-MS/MS Analysis of Benzodiazepines in Human Urine
We hereby present a fast, high-throughput, and clinical LC-MS/MS assay for the simultaneous analysis of benzodiazepines in human urine. The assay is...
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Quantitative LC-MS/MS Analysis of Amphetamines and Cocaine in Human Urine
We hereby present a fast and high-throughput LC-MS/MS assay for the simultaneous analysis of amphetamines and cocaine in human urine. The assay is...
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A Liquid Chromatography-Tandem Mass Spectrometry Assay for Quantification of Ethyl Glucuronide and Ethyl Sulfate in Urine
Ethyl glucuronide and ethyl sulfate emerged as the biomarkers of choice for detection of ethanol use as the required sample is urine, enabling easy...
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Quantitative LC-MS/MS Analysis of Opiates and Opioids in Human Urine
We hereby present a direct, clinical LC-MS/MS assay for the simultaneous analysis of opiates and opioids in human urine. The assay is used as...
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Liquid Chromatography-Tandem Mass Spectrometry Method for the Quantification of Plasma Busulfan
Busulfan is an alkylating agent and functions as a myeloablative and anti-leukemic chemotherapy drug. It is widely used with cyclophosphamide for...
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Detection of 41 Drugs and Metabolites in Urine with Internal Hydrolysis Control by Liquid Chromatography-Tandem Mass Spectrometry
Regular monitoring of pain management and substance use disorder patients through urine drug screening is important for assessing patient compliance...
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Turbulent Flow Liquid Chromatography-Tandem Mass Spectrometry Methods for Antiepileptic Drug Quantitation in Serum
Epilepsy is characterized by abnormal electrical discharges in the brain that result in unprovoked seizures. Pharmacotherapy with antiepileptic drugs...
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Liquid Chromatography-Tandem Mass Spectrometry-Based Therapeutic Monitoring of Plasma Atovaquone Concentrations in Pediatric Patients
Atovaquone is an FDA-approved antiparasitic and antifungal therapeutic that is currently used as a prophylactic agent to prevent Pneumocystis carinii...
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Spatial Proteomics of Single Hepatocytes with Multiplexed Data-Independent Acquisition (mDIA)
Spatially resolved mass spectrometry-based proteomics at single-cell resolution promises to provide insights into biological heterogeneity. We...