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Construction of Carbocycles via Zirconacycles and Titanacycles
Metal-mediated selective construction of useful carbocyclic compounds from multi-component reaction systems has attracted much attention in recent...
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Inclusion Bodies: Formation and Utilisation
The efficient in vivo folding of many heterologous proteins is a major bottleneck of high level production in bacterial hosts and simple optimisation...
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Monitoring of Stress Responses
New developments in the RNA analysis techniques now enable a comprehensive view on the bacterial physiology under bioprocess conditions. The DNA-chip...
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Analysis and Control of Proteolysis of Recombinant Proteins in Escherichia coli
Proteolysis is one of the reasons for poor production of recombinant proteins in Escherichia coli. Important properties of E. coli proteases, which...
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Novel Genes Involved in Cephalosporin Biosynthesis: The Three-component Isopenicillin N Epimerase System
Cephalosporin is one of the best β-lactam antibiotics, widely used in the treatment of infectious diseases. It is synthesized by Acremonium...
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Palladium-Catalyzed Heck Arylations in the Synthesis of Active Pharmaceutical Ingredients
The utility of inter- and intramolecular Heck arylations in the synthesis of intermediates for the preparation of active pharmaceutical ingredients...
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The Application of Multi-Parameter Flow Cytometry to Monitor Individual Microbial Cell Physiological State
The development of multi-parameter flow cytometric techniques in our laboratories has led to a functional classification of the physiological state...
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Development of Transition Metal-Mediated Cyclopropanation Reactions
A brief discussion of the methods for cyclopropane formation emphasizing organometallic reagents and catalysts is followed by several examples of the...
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Metallocene-Catalyzed Selective Reactions
Transition metal cyclopentadienyl complexes constitute a large family of compounds that can be used as catalyst for a number of organic...
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Regulation of Cephalosporin Biosynthesis
The filamentous fungus Acremonium chrysogenum is the natural producer of the β-lactam antibiotic cephalosporin C and is as such used worldwide in...
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Control of Fluxes Towards Antibiotics and the Role of Primary Metabolism in Production of Antibiotics
Yield improvements in antibiotic-producing strains have classically been obtained through random mutagenesis and screening. An attractive alternative...
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Non-Salen Metal-Catalyzed Asymmetric Dihydroxylation and Asymmetric Aminohydroxylation of Alkenes. Practical Applications and Recent Advances
Over the past two decades the asymmetric dihydroxylation (AD) and asymmetric aminohydroxylation (AA) of alkenes has attracted a great deal of...
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Stereospecific Olefin Polymerization Catalyzed by Metallocene Complexes
Metallocene complexes that serve as stereoselective olefin polymerization catalysts are described. The polymerization of propylene, styrene, methyl...
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Diastereoselective, Enantioselective, and Regioselective Carboalumination Reactions Catalyzed by Zirconocene Derivatives
Coordinatively unsaturated alkylzirconocene derivatives can undergo stereo-, and regioselective carbometallation reactions of synthetic utility via...
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Biochemistry and General Genetics of Nonribosomal Peptide Synthetases in Fungi
Peptides like penicillin or cyclosporin are nonribosomally synthesised by large multifunctional enzymes. Peptide synthetase genes are coexpressed...
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Compartmentalization and Transport in β-Lactam Antibiotics Biosynthesis
Classical strain improvement of β-lactam producing organisms by random mutagenesis has been a powerful tool during the last century. Current insights...