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The ubiquitin-like protein UBTD1 promotes colorectal cancer progression by stabilizing c-Myc to upregulate glycolysis
Dysfunction of the ubiquitin-proteasome system (UPS) is involved in the pathogenesis of various malignancies including colorectal cancer (CRC)....
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Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases
Mitotic catastrophe (MC), which occurs under dysregulated mitosis, represents a fascinating tactic to specifically eradicate tumor cells. Whether...
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Early biomarkers in the presymptomatic phase of cognitive impairment: changes in the endocannabinoidome and serotonergic pathways in Alzheimer's-prone mice after mTBI
BackgroundDespite extensive studies on the neurobiological correlates of traumatic brain injury (TBI), little is known about its molecular...
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Soft tissue hemangioma of the right upper extremity with intraosseous extension and secondary intravascular papillary endothelial hyperplasia
Intravascular papillary endothelial hyperplasia (IPEH), also known as Masson’s tumor, is an uncommon exuberant form of organizing thrombus that may...
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Multimodal training protocols on unstable rather than stable surfaces better improve dynamic balance ability in older adults
BackgroundThere has been growing interest in using unstable devices in training protocols. This study aimed to assess the effectiveness of two...
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Specific CD4+ T cell phenotypes associate with bacterial control in people who ‘resist’ infection with Mycobacterium tuberculosis
A subset of individuals exposed to Mycobacterium tuberculosis ( Mtb ) that we refer to as ‘resisters’ (RSTR) show evidence of IFN-γ − T cell responses...
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Nuclear alpha-synuclein accelerates cell senescence and neurodegeneration
BackgroundThe progression of Parkinson’s disease (PD) is related to ageing. The accumulation of nuclear alpha-synuclein (α-syn) may accelerate the...
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Orchestration of antiviral responses within the infected central nervous system
Many newly emerging and re-emerging viruses have neuroinvasive potential, underscoring viral encephalitis as a global research priority. Upon entry...
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AXDND1 is required to balance spermatogonial commitment and for sperm tail formation in mice and humans
Dynein complexes are large, multi-unit assemblies involved in many biological processes via their critical roles in protein transport and axoneme...
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Increased ONECUT2 induced by Helicobacter pylori promotes gastric cancer cell stemness via an AKT-related pathway
Helicobacter pylori (HP) infection initiates and promotes gastric carcinogenesis. ONECUT2 shows promise for tumor diagnosis, prognosis, and...
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Combined neurokinin-1 receptor antagonist and sorafenib is a promising approach for hepatocellular carcinoma therapy
BackgroundHCC (Hepatocellular carcinoma) is the most common primary malignant cancer in the liver. Treatment options to incurable HCC such as...
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CAR-NKT Cells in Asthma: Use of NKT as a Promising Cell for CAR Therapy
NKT cells, unique lymphocytes bridging innate and adaptive immunity, offer significant potential for managing inflammatory disorders like asthma....
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Patientenbefragung zum Einsatz von Videosprechstunden in der ambulanten Behandlung von chronischem Pruritus
BackgroundAnalyses of patient evaluations and barriers to the implementation of teledermatology procedures are still rare. The aim of this study was...
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First detection and a new avian host of the tick Ixodes ventalloi Gil Collado, 1936, in Slovakia
This study describes the first detection of Ixodes ventalloi in Slovakia. Two engorged females of I. ventalloi were collected from Dunnocks ( Prunella...
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A wingless fly on a winged mammal: host-parasite dynamics between Basilia travassosi (Diptera: Nycteribiidae) and Myotis lavali (Chiroptera: Vespertilionidae)
Nycteribiidae encompasses a specialized group of wingless blood-sucking flies that parasitize bats worldwide. Such relationships are frequently...
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Proteomic insights into extracellular vesicles in ALS for therapeutic potential of Ropinirole and biomarker discovery
BackgroundExtracellular vesicles (EVs) hold the potential for elucidating the pathogenesis of amyotrophic lateral sclerosis (ALS) and serve as...
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Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury
Ischemia-induced retinopathy is a hallmark finding of common visual disorders including diabetic retinopathy (DR) and central retinal artery and vein...
