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Effects of Sex Steroids on Innate and Adaptive Immunity
Estrogens and androgens are classically recognized as reproductive sex steroid hormones because of their well-documented effects on reproductive...
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A small molecule compound targeting hemagglutinin inhibits influenza A virus and exhibits broad-spectrum antiviral activity
Influenza A virus (IAV) is a widespread pathogen that poses a significant threat to human health, causing pandemics with high mortality and...
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Minimally invasive approach in a rare emergency surgery, gallbladder perforation
BackgroundGallbladder perforations are challenging to manage for surgeons due to their high morbidity and mortality, rarity, and surgical approach....
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Extrakorporale Verfahren bei Vergiftungen
In rare cases, intoxicated patients may require an extracorporeal procedure for enhanced toxin elimination. The Extracorporeal Treatments in...
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Central nervous system involvement in chronic lymphocytic leukemia: a case report and review of literature
BackgroundCentral nervous system involvement in chronic lymphocytic leukemia rarely occurs, and there is no standard therapy for central nervous...
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PICC tip dislodgement causing massive pleural effusion and atelectasis with acute respiratory failure: a case report
Peripheral intravenous central catheter (PICC) is a common tool for intravenous infusion for children who need central venous access. Although it is...
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Conditional survival and the prognostic value of serum carcinoembryonic antigen level in oldest old with colorectal cancer
BackgroundTo evaluate the clinical value of serum CEA levels and their implications on the diagnostic value of the conventional TNM staging system in...
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A possible role of lncRNA MEG3 and lncRNA MAFG-AS1 on miRNA 147-b in the pathogenesis of Behcet’s disease
Behcet’s disease (BD) is a multisystem disease with altered Toll-like receptors (TLRs) on macrophages. Long noncoding RNA Maternally expressed gene 3...
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Zinc finger 259 gene polymorphisms in Egyptian patients with metabolic syndrome and its association with dyslipidemia
BackgroundZinc finger protein 1 (ZPR1), encoded by the ZNF259 gene, plays crucial roles in transcriptional regulation and cell cycle progression....
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Non-surgical vs. surgical treatment of distal radius fractures: a meta-analysis of randomized controlled trials
PurposeTo compare the clinical outcomes between nonsurgical and surgical treatment of distal radius fracture.
MethodsWe performed a systematic...
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Clinical characteristics of extracorporeal cardiopulmonary resuscitation in China: a multicenter retrospective study
PurposeExtracorporeal cardiopulmonary resuscitation (ECPR) might markedly increase the survival of selected patients with refractory cardiac arrest....
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Effect of NLRP3 gene knockdown on pyroptosis and ferroptosis in diabetic cardiomyopathy injury
Diabetic cardiomyopathy (DCM) is a chronic disease caused by diabetes mellitus, which is recognized as a worldwide challenging disease. This study...
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Randomized investigation of increased dialyzer membrane hydrophilicity on hemocompatibility and performance
BackgroundHemodialyzers should efficiently eliminate small and middle molecular uremic toxins and possess exceptional hemocompatibility to improve...
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Safety of Rimegepant in Adults with Migraine and Cardiovascular Risk Factors: Analysis of a Multicenter, Long-Term, Open-Label Study
IntroductionCardiovascular (CV) risk factors can limit treatment options for migraine. Rimegepant is an orally administered small-molecule calcitonin...
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Comparison of low versus high (standard) intraabdominal pressure during laparoscopic colorectal surgery: systematic review and meta-analysis
BackgroundTo evaluate outcomes of low with high intraabdominal pressure during laparoscopic colorectal resection surgery.
MethodsA systematic search...
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Neutralizing antibody responses assessment after vaccination in people living with HIV using a surrogate neutralization assay
ObjectiveHIV has been reported to interfere with protective vaccination against multiple pathogens, usually through the decreased effectiveness of...
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Refractory type 1 plastic bronchitis in a child; case report
BackgroundPlastic bronchitis (PB) is a rare pediatric pulmonary condition characterized by the production of branching bronchial casts that cause...
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Trichohepatoenteric syndrome type 1: expanding the clinical spectrum of THES type 1 due to a homozygous variant in the SKIC3 gene
Trichohepatoenteric syndrome (THES), also known as phenotypic diarrhea or syndromic diarrhea, is a rare autosomal recessive genetic disorder caused...
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A mixed meal tolerance test predicts onset of type 2 diabetes in Southwestern Indigenous adults
Background/ObjectiveTo identify predictors of incident type 2 diabetes using a mixed meal tolerance test (MMTT).
MethodsAdult Indigenous Americans...
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Predictive role of platelets to lymphocytes ratio and neutrophil to lymphocytes ratio in COPD exacerbation
BackgroundThe hallmark of COPD is the progressive destruction of the lung parenchyma, which is frequently brought on by the body's inflammatory...
