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Effects of Sex Steroids on Innate and Adaptive Immunity
Estrogens and androgens are classically recognized as reproductive sex steroid hormones because of their well-documented effects on reproductive...
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Preclinical and clinical advances to overcome hypoxia in glioblastoma multiforme
Glioblastoma multiforme (GBM) is the most common adult primary brain tumor. The standard clinical treatment of GBM includes a maximal surgical...
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The relationship between the functional movement screen and isokinetic muscle strength around the knee in different sports
The aim of this study was to determine objective data of the relationship between the Functional Movement Screen (FMS) and isokinetic muscle strength...
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Ultra-processed food consumption and risk of diabetes: results from a population-based prospective cohort
Aims/hypothesisUnderstanding the impact of the overall construct of ultra-processed foods on diabetes risk can inform dietary approaches to diabetes...
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Gastrointestinal parasites of Wolffsohn’s viscacha (Chinchillidae: Lagidium wolffsohni), an endemic rodent species from the wild Patagonia
Parasites are ubiquitous in wildlife populations and have a profound impact on population dynamics. Interest in parasites of wildlife has increased...
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Sex differences in membrane properties and cellular excitability of dopamine D1 receptor-expressing neurons within the shell of the nucleus accumbens of pre- and mid-adolescent mice
BackgroundThe transition from childhood to adulthood, or adolescence, a developmental stage, is characterized by psychosocial and biological changes....
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The eEF2 kinase coordinates the DNA damage response to cisplatin by supporting p53 activation
Eukaryotic elongation factor 2 (eEF2) kinase (eEF2K) is a stress-responsive hub that inhibits the translation elongation factor eEF2, and...
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IL-4/IL-4R axis signaling drives resistance to immunotherapy by inducing the upregulation of Fcγ receptor IIB in M2 macrophages
In recent years, immunotherapy, particularly PD-1 antibodies, have significantly enhanced the outcome of gastric cancer patients. Despite these...
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The ubiquitin-like protein UBTD1 promotes colorectal cancer progression by stabilizing c-Myc to upregulate glycolysis
Dysfunction of the ubiquitin-proteasome system (UPS) is involved in the pathogenesis of various malignancies including colorectal cancer (CRC)....
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Bedside electromyography for clinical assessment of sacral motor and reflex activity adapted for patients hospitalized with acute neurological conditions: a pilot study
Study designPilot cohort study.
ObjectiveTo develop and implement a sacral electromyographic (sEMG) technique at bedside to ascertain sparing of...
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Use of diabetes technology in children
Children with type 1 diabetes and their caregivers face numerous challenges navigating the unpredictability of this complex disease. Although the...
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Multimodal training protocols on unstable rather than stable surfaces better improve dynamic balance ability in older adults
BackgroundThere has been growing interest in using unstable devices in training protocols. This study aimed to assess the effectiveness of two...
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Specific CD4+ T cell phenotypes associate with bacterial control in people who ‘resist’ infection with Mycobacterium tuberculosis
A subset of individuals exposed to Mycobacterium tuberculosis ( Mtb ) that we refer to as ‘resisters’ (RSTR) show evidence of IFN-γ − T cell responses...
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Nuclear alpha-synuclein accelerates cell senescence and neurodegeneration
BackgroundThe progression of Parkinson’s disease (PD) is related to ageing. The accumulation of nuclear alpha-synuclein (α-syn) may accelerate the...
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Orchestration of antiviral responses within the infected central nervous system
Many newly emerging and re-emerging viruses have neuroinvasive potential, underscoring viral encephalitis as a global research priority. Upon entry...
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AXDND1 is required to balance spermatogonial commitment and for sperm tail formation in mice and humans
Dynein complexes are large, multi-unit assemblies involved in many biological processes via their critical roles in protein transport and axoneme...
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Advances in diabetes technology to improve the lives of people with cystic fibrosis
People with cystic fibrosis (CF) are at risk for dysglycaemia caused by progressive beta cell dysfunction and destruction due to pancreatic exocrine...
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Dietary Supplementation Strategies for Improving Training Adaptations, Antioxidant Status and Performance of Volleyball Players: A Systematic Review
PurposeVolleyball demands high physical performance including agility, speed, endurance and muscular strength. As volleyball players explore methods...
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Development and validation of a novel screening tool for deep vein thrombosis in patients with spinal cord injury: A five-year cross-sectional study
Study designCross-sectional study.
ObjectivesDeep vein thrombosis (DVT) presents a significant risk of complication in patients with spinal cord...
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Does Performing Resistance Exercise with a Partial Range of Motion at Long Muscle Lengths Maximize Muscle Hypertrophic Adaptations to Training?
BackgroundOver the past few years, the effects of manipulating range of motion (ROM) on muscle hypertrophy has garnered a considerable amount of...