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Modeling Calcium Waves
We present an introduction to the mathematics of calcium waves, both intracellular and intercellular. After a discussion of the earlier models I... -
Regulation of IP 3 Receptors by IP 3 and Ca 2+
Inositol 1,4,5-trisphosphate ( IP 3) receptors are intracellular Ca 2+ channels that mediate release of Ca 2+ from intracellular stores. The channels... -
Hormone-Mediated Intercellular Calcium Signalling in an Insect Salivary Gland – Pathways and Mechanisms
The salivary glands of the blowfly Calliphora vicina are a favourable preparation for investigations into spatio-temporal Ca 2+ dynamics in an intact... -
From Simple to Complex Ca 2+ Oscillations: Regulatory Mechanisms and Theoretical Models
Intracellular Ca 2+ oscillations most often appear as regular spikes. However, complex Ca 2+ oscillations in the form of bursting or chaos have also... -
Functions of Rab GTPases in organelle biogenesis
Rab GTPases regulate diverse aspects of the biogenesis of secretory and endocytic organelles. The conformational changes that accompany GTP binding... -
Introduction: Regulatory processes, an emerging feature in intracellular membrane traffic
The subject of this volume is the molecular mechanism of the intracellular membrane trafficking, a central eukaryotic cell biological process. In the... -
Risk Evaluation of Dietary and Dermal Exposure to Musk Fragrances
Synthetic musk compounds comprising nitro musks, polycyclic musks and macrocyclic musks are used in fragrances which are added to a variety of... -
Synthetic Musks in Bioindicators: Monitoring Data of Fish and Human Milk Samples from the Czech Republic
Until the middle of the 1990s, no attention was paid to the pollution of the environment in Czech Republic by synthetic musk fragrances and to the... -
Synthetic Musks in Suspended Particulate Matter (SPM), Sediment, and Sewage Sludge
Nitro musk and polycyclic musk fragrances accumulate in solid matters of the aquatic environment. They are analyzed by extraction with an organic... -
Enantioselective Analysis of Polycyclic Musks as a Versatile Tool for the Understanding of Environmental Processes
In this chapter the application of enantioselective chromatography to process studies related to the microbial, enzymatic and photochemical... -
Biotic and Abiotic Transformation Pathways of Synthetic Musks in the Aquatic Environment
Synthetic musks are being transformed to intermediates or relatively stable metabolites that may exhibit a strong potential for environmental harm.... -
Post-implantation analysis of genomic variations in the progeny from develo** fetus to birth
The analysis of genomic variations in offspring after implantation has been infrequently studied. In this study, we aim to investigate the extent of de...
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Production and Formulation of Adenovirus Vectors
Adenovirus vectors have attracted considerable interest over the past decade, with ongoing clinical development programs for applications ranging... -
Nonviral Delivery of Cancer Genetic Vaccines
The potential use of genetic vaccines to address numerous diseases including cancer is promising, but currently unrealized. Here, we review... -
Advanced Targeting Strategies for Murine Retroviral and Adeno-associated Viral Vectors
Targeted gene delivery involves broadening viral tropism to infect previously nonpermissive cells, replacing viral tropism to infect a target cell... -
Molecular Conjugates
Molecular conjugates are nanometer-sized entities consisting of synthetic materials (lipids, polycations, targeting agents, and so on) and nucleic... -
Role of NAADP in Coordinating Spatiotemporal Aspects of Calcium Signalling
We outline the roles of two low molecular weight phosphorylated compounds as intracellular messengers in calcium signaling. These new intracellular... -
Building a Wave – Models of the Puff-to-Wave Transition
Ca2+ release channels open and close randomly because of random binding and dissociation of Ca2+ and IP3 to their subunits. They are arranged in... -
The Endoplasmic Reticulum: A Central Player in Cell Signalling and Protein Synthesis
In addition to being the principle intracellular Ca 2+ store, the endoplasmic reticulum (ER) is the initial site of synthesis and folding of membrane...