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Associations between quantitative measures of mammographic density and terminal ductal lobular unit involution in Chinese breast cancer patients
BackgroundHigher mammographic density (MD), a radiological measure of the proportion of fibroglandular tissue in the breast, and lower terminal duct...
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Roger’s diffusion of innovations theory and the adoption of a patient portal’s digital anamnesis collection tool: study protocol for the MAiBest project
BackgroundGerman hospitals are legally obliged to implement digital patient portals within the next years. Systematic reviews show that the use of...
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Digital histology of retinal microaneurysms as provided by dense B-scan (DART) OCTA: characteristics and clinical relevance in diabetic retinopathy
BackgroundRetinal microaneurysms (MAs) are among the earliest signs of diabetic retinopathy (DR) and can be classified in several subtypes by...
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Impact of physical activity on caloric and macronutrient intake in children and adolescents: a systematic review and meta-analysis of randomized controlled trials
BackgroundPhysical activity is widely promoted to maintain and improve health across all ages. Investigating how physical activity affects subsequent...
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Peptides for microbe-induced cancers: latest therapeutic strategies and their advanced technologies
Cancer is a significant global health concern associated with multiple distinct factors, including microbial and viral infections. Numerous studies...
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Implementing evidence-based practices to improve primary care for high-risk patients: study protocol for the VA high-RIsk VETerans (RIVET) type III effectiveness-implementation trial
BackgroundPatients with significant multimorbidity and other factors that make healthcare challenging to access and coordinate are at high risk for...
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The longitudinal associations of remote intergenerational communication with instrumental activities of daily living among older adults
Maintaining independence in instrumental activities of daily living is crucial for older adults in an ageing society. This study, utilizing...
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Diagnostic conundrum of Superficial CD34-positive fibroblastic tumor (SCPFT): a series of five cases
Superficial CD34-positive fibroblastic tumor (SCPFT) is an extremely rare neoplasm with an indolent behavior. It was incorporated for the first time...
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Sex ratio at birth across 100 years in Sweden and risk of cardiovascular disease and all-cause mortality – a national register study
The human sex ratio at birth (SRB) undergoes temporary changes around a mean proportion of 0.51 male births. SRB has been well studied for...
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Teamwork and implementation of innovations in healthcare and human service settings: a systematic review
BackgroundImplementation of new practices in team-based settings requires teams to work together to respond to new demands and changing expectations....
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Gastric band removal: mind the arterial anastomoses!
Bariatric surgery may sometimes be challenging and may lead to severe complications. Surgical re-intervention in such cases is not the preferred...
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Robot-Assisted Pancreaticoduodenectomy with Hemicircumferential Dissection of Nerve Plexus Around the Superior Mesenteric Artery
BackgroundPancreatic head cancer with perineural invasion of the superior mesenteric artery (SMA) requires dissection of the nerve plexus around the...
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NR2F1 overexpression alleviates trophoblast cell dysfunction by inhibiting GDF15/MAPK axis in preeclampsia
Abnormal functions of trophoblast cells are associated with the pathogenesis of preeclampsia (PE). Nuclear receptor subfamily 2 group F member 1...
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A dual-targeting approach with anti-IL10R CAR-T cells engineered to release anti-CD33 bispecific antibody in enhancing killing effect on acute myeloid leukemia cells
BackgroundImmunotherapies, including chimeric antigen receptor (CAR) T cells and bispecific antibodies (BsAbs), encounter several challenges in the...
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SEOM–GEICO clinical guideline on epithelial ovarian cancer (2023)
In recent years, the incorporation of new strategies to the therapeutic armamentarium has completely changed the outcomes of epithelial ovarian...
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Advancements in Nano-Mandoor Bhasma: Unravelling the Particle Size–Ascorbic Acid Synergy for Enhanced Iron Bioavailability for Anemia Treatment
Mandoor Bhasma (MB) medicine, based on classical Indian Ayurveda, was size- and surface-modified to improve its therapeutic efficiency for treating...
