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The Broad Spectrum of Responses to Oxidative Stress in Proliferating Cells
Proliferating mammalian cells exhibit a broad spectrum of responses to oxidative stress, depending on the stress level encountered. Very low levels... -
Low Molecular Weight Antioxidants
Low molecular weight antioxidants are an important part of the antioxidative defense mechanisms of cells and organisms. This chapter gives a short... -
Environmental Oxidative Stress – Environmental Sources of ROS
Environmental factors are known sources for oxidative stress. In consequence of the numerous influences that define our environment, environmental... -
Endogenous Oxidant-Generating Systems
Although organisms respiring air oxygen use their energy sources in an optimal way they are threatened by the compulsory formation of reactive oxygen... -
Glutathione
Glutathione is the most abundant non-protein thiol in cells. It is a tripeptide with two important structural features: the thiol group and the... -
Modulation of Cellular Signaling Processes by Reactive Oxygen Species
Exposure of cells to reactive oxygen species (ROS) may result not only in cell death by excessive oxidation of biomolecules but also cause the... -
Chemical Modifications of Biomolecules by Oxidants
There is strong evidence in support of the oxidation of biomolecules during normal physiology and under conditions of environmental or pathological... -
DNA Repair: Mechanisms and Measurements
The early findings that significant amounts of modifications are induced to the cellular DNA both spontaneously and as a consequence of metabolism... -
Mitochondrial Free Radical Production, Antioxidant Defenses and Cell Signaling
Mitochondria were classically recognized as the organelles that produce the energy required to drive the endergonic processes of cell life, but now... -
Protein Repair and Degradation
Protein oxidation is one of the important processes taking place during oxidative stress. Numerous amino acids can be modified within proteins... -
Superoxide Dismutases and Catalase
Superoxide dismutases (SODs) and catalase represent the primary enzymatic defense against reactive oxygen species. Both enzymes are present in... -
A case of death after the severing three appendiceal arteries during appendectomy
IntroductionAcute appendicitis is one of the most common acute abdominal issues requiring surgery and is usually treated by appendectomy. During the...
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Forensic significance of VOCs profiling in decayed ante- and post-mortem injuries by GC×GC-TOF/MS
Accurately identifying and differentiating the types of injuries in decomposed corpses is a major challenge in forensic identification. Forensic...
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The impact of physical activity and exercise interventions on symptoms for women experiencing menopause: overview of reviews
BackgroundWomen experiencing problematic menopausal symptoms report lower health-related quality of life and greater healthcare use than women...
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The efficacy of early office hysteroscopy in preventing intrauterine adhesions after abortion: a randomized controlled trial
BackgroundIntrauterine adhesions (IUA) are a challenging clinical problem in reproductive infertility. The most common causes are intrauterine...
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Clinical Audit of Obstetric Hysterectomy in a Tertiary Care Centre: An Observational Retroprospective Study
Purpose of StudyThe purpose of this study is to analyse the profile and characteristics of patients who may undergo obstetric hysterectomy, to study...
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Diagnostic Ability and Reproducibility of NICE 2017 Intrapartum Cardiotocography Interpretation Guidelines: A Prospective Observational Study
Purpose of StudyAssessment of accuracy, intra-observer and inter-observer and agreement for CTG interpretation utilizing NICE guidelines 2017.
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Clinical Investigation into Survival Outcomes Among Stage IV Epithelial Ovarian Cancer Patients Receiving Curative Treatment: Indian Setting
ObjectiveCurrently, there is scanty data regarding patients specifically with stage IV epithelial ovarian cancer (EOC) as many reports combine...
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Total gonadotropin dose did not affect euploid blastocyst rates: an analysis of more than 19,000 oocytes
BackgroundTo evaluate whether increasing total gonadotropin (Gn) dose is associated with changes in euploid blastocyst rate in preimplantation...