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Optimization of biotransformation processes of Camarosporium laburnicola to improve production yields of potent telomerase activators
BackgroundTelomerase activators are promising agents for the healthy aging process and the treatment/prevention of short telomere-related and...
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Redundancy of p75NTR neurotrophin receptor function in development, growth and fertility in the rat
The p75NTR neurotrophin receptor has positive and negative roles regulating cell survival in the nervous system. Unambiguous interpretation of p75NTR...
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Recombinant human enamelin produced in Escherichia coli promotes mineralization in vitro
BackgroundEnamelin is an enamel matrix protein that plays an essential role in the formation of enamel, the most mineralized tissue in the human...
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Antibacterial and antibiofilm potentials of vancomycin-loaded niosomal drug delivery system against methicillin-resistant Staphylococcus aureus (MRSA) infections
The threat of methicillin-resistant Staphylococcus aureus (MRSA) is increasing worldwide, making it significantly necessary to discover a novel way...
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Optimisation of indole acetic acid production by Neopestalotiopsis aotearoa endophyte isolated from Thymus vulgaris and its impact on seed germination of Ocimum basilicum
BackgroundMicrobial growth during plant tissue culture is a common problem that causes significant losses in the plant micro-propagation system. Most...
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Map** a sustainable approach: biosynthesis of lactobacilli-silver nanocomposites using whey-based medium for antimicrobial and bioactivity applications
This study explores a sustainable approach for synthesizing silver nanocomposites (AgNCs) with enhanced antimicrobial and bioactivity using safe Lactobacillus...
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Production of succinate with two CO2 fixation reactions from fatty acids in Cupriavidus necator H16
BackgroundBiotransformation of CO 2 into high-value-added carbon-based products is a promising process for reducing greenhouse gas emissions. To...
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Design of a novel multi-epitope vaccine against Marburg virus using immunoinformatics studies
Marburg virus (MARV) is a highly contagious and virulent agent belonging to Filoviridae family. MARV causes severe hemorrhagic fever in humans and...
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Construction of lignan glycosides biosynthetic network in Escherichia coli using mutltienzyme modules
BackgroundDue to the complexity of the metabolic pathway network of active ingredients, precise targeted synthesis of any active ingredient on a...
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Natural dyes developed by microbial-nanosilver to produce antimicrobial and anticancer textiles
Develo** special textiles (for patients in hospitals for example) properties, special antimicrobial and anticancer, was the main objective of the...
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Optimization, gene cloning, expression, and molecular docking insights for enhanced cellulase enzyme production by Bacillus amyloliquefaciens strain elh1
BackgroundIn this study, we isolated a cellulase-producing bacterium, Bacillus amyloliquefaciens strain elh, from rice peel. We employed two...
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Streamlining heterologous expression of top carbonic anhydrases in Escherichia coli: bioinformatic and experimental approaches
BackgroundCarbonic anhydrase (CA) enzymes facilitate the reversible hydration of CO 2 to bicarbonate ions and protons. Identifying efficient and...
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Interplay between photosynthetic electron flux and organic carbon sinks in sucrose-excreting Synechocystis sp. PCC 6803 revealed by omics approaches
BackgroundAdvancing the engineering of photosynthesis-based prokaryotic cell factories is important for sustainable chemical production and requires...
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A review on microbes mediated resource recovery and bioplastic (polyhydroxyalkanoates) production from wastewater
BackgroundPlastic is widely utilized in packaging, frameworks, and as coverings material. Its overconsumption and slow degradation, pose threats to...
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Rational construction of a high-quality and high-efficiency biosynthetic system and fermentation optimization for A82846B based on combinatorial strategies in Amycolatopsis orientalis
BackgroundOritavancin is a new generation of semi-synthetic glycopeptide antibiotics against Gram-positive bacteria, which served as the first and...
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Increased stable integration efficiency in CHO cells through enhanced nuclear localization of Bxb1 serine integrase
BackgroundMammalian display is an appealing technology for therapeutic antibody development. Despite the advantages of mammalian display, such as...
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Phytoremediation: a transgenic perspective in omics era
Phytoremediation is an environmental safety strategy that might serve as a viable preventative approach to reduce soil contamination in a...
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Engineering strategies for enhanced 1′, 4′-trans-ABA diol production by Botrytis cinerea
BackgroundCurrently, industrial fermentation of Botrytis cinerea is a significant source of abscisic acid (ABA). The crucial role of ABA in plants...
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‘Small volume—big problem’: culturing Yarrowia lipolytica in high-throughput micro-formats
With the current progress in the ‘design’ and ‘build’ stages of the ‘design-build-test-learn’ cycle, many synthetic biology projects become...
