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Human genetics

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  2. Advanced Targeting Strategies for Murine Retroviral and Adeno-associated Viral Vectors

    Targeted gene delivery involves broadening viral tropism to infect previously nonpermissive cells, replacing viral tropism to infect a target cell...
    Julie H. Yu, David V. Schaffer in Gene Therapy and Gene Delivery Systems
    Chapter

  3. Nonviral Delivery of Cancer Genetic Vaccines

    The potential use of genetic vaccines to address numerous diseases including cancer is promising, but currently unrealized. Here, we review...
    Steven R. Little, Robert Langer in Gene Therapy and Gene Delivery Systems
    Chapter

  4. Production and Formulation of Adenovirus Vectors

    Adenovirus vectors have attracted considerable interest over the past decade, with ongoing clinical development programs for applications ranging...
    Nedim E. Altaras, John G. Aunins, ... Jayanthi J. Wolf in Gene Therapy and Gene Delivery Systems
    Chapter

  5. Molecular Conjugates

    Molecular conjugates are nanometer-sized entities consisting of synthetic materials (lipids, polycations, targeting agents, and so on) and nucleic...
    Jeremy Heidel, Swaroop Mishra, Mark E. Davis in Gene Therapy and Gene Delivery Systems
    Chapter

  6. Adeno-associated Virus as a Gene Therapy Vector: Vector Development, Production and Clinical Applications

    Adeno-associated virus (AAV) has emerged as an attractive vector for gene therapy. AAV vectors have successfully been utilized to promote...
    Joshua C. Grieger, Richard J. Samulski in Gene Therapy and Gene Delivery Systems
    Chapter

  7. Lentiviral Vectors

    We review the use of lentiviral vectors in current human gene therapy applications that involve genetic modification of nondividing tissues with...
    Nils Loewen, Eric M. Poeschla in Gene Therapy and Gene Delivery Systems
    Chapter

  8. Plasmid Vaccines and Therapeutics: From Design to Applications

    In the late 1980s, Vical and collaborators discovered that the injection into tissues of unformulated plasmid encoding various proteins resulted in...
    Marston Manthorpe, Peter Hobart, ... Alain Rolland in Gene Therapy and Gene Delivery Systems
    Chapter

  10. Psychological and ethical issues raised by genomic in paediatric care pathway, a qualitative analysis with parents and childhood cancer patients

    In paediatric oncology, genomics raises new ethical, legal and psychological issues, as somatic and constitutional situations intersect throughout...

    Marion Droin-Mollard, Sandrine de Montgolfier, ... Khadija Lahlou-Laforêt in European Journal of Human Genetics
    Article Open access 13 July 2024

  11. Antibody MYH9 and Antibiotic Lidamycin Inhibit the Growth and Proliferation of Lung Cancer Cells and Induce Their Apoptosis

    The aim of this study was to investigate the impact of the antibiotic lidamycin (LDM) and the targeted therapy with the antibody Myosin heavy chain 9...

    Jie Jiang, Ruoyu Hu, ... Wei He in Molecular Biotechnology
    Article 13 July 2024

  12. Effect of α7 nAChR-autophagy axis of deciduous tooth pulp stem cells in regulating IL-1β in the process of physiological root resorption of deciduous teeth

    Abstract

    Physiological root resorption of deciduous teeth is a normal phenomenon occurring during the developmental stages of children. Previous...

    Tiankai Di, Yujiang Chen, ... Lulu Wang in Journal of Molecular Medicine
    Article 13 July 2024

  14. Total gonadotropin dose did not affect euploid blastocyst rates: an analysis of more than 19,000 oocytes

    Background

    To evaluate whether increasing total gonadotropin (Gn) dose is associated with changes in euploid blastocyst rate in preimplantation...

    Jun Shuai, Weiwei Liu, ... Hong Ye in Journal of Assisted Reproduction and Genetics
    Article 13 July 2024

  15. Susceptibility gene mutations in germline and tumors of patients with HER2-negative advanced breast cancer

    Germline mutations in BRCA1 and BRCA2 (g BRCA1/2 ) are required for a PARP inhibitor therapy in patients with HER2-negative (HER2−) advanced breast...

    Peter A. Fasching, Chunling Hu, ... Fergus J. Couch in npj Breast Cancer
    Article Open access 13 July 2024

  16. CCT6A promotes cell proliferation in colon cancer by targeting BIRC5 associated with p53 status

    Chaperonin-containing TCP1 (CCT) is a multi-subunit complex, known to participate the correct folding of many proteins. Currently, the mechanism...

    Han Zhang, Taotao Zheng, ... Huawen Liu in Cancer Gene Therapy
    Article 13 July 2024

  17. First Insight into the Phylogenetic Diversity of Bovicola caprae Infesting Goats of Different Agro-climatic Locations in India

    Bovicola caprae is an important obligate ectoparasite of goats worldwide including India. The present study aimed at the molecular confirmation,...

    Aman D. Moudgil, Anil K. Nehra, ... Sukhdeep Vohra in Biochemical Genetics
    Article 13 July 2024

  18. Comprehensive Quality Analysis of Conventional and Novel Biomarkers in Diagnosing and Predicting Prognosis of Coronary Artery Disease, Acute Coronary Syndrome, and Heart Failure, a Comprehensive Literature Review

    Coronary artery disease (CAD), acute coronary syndrome (ACS), and heart failure (HF) are major global health issues with high morbidity and mortality...

    Muhammad Abubakar, Umema Irfan, ... Farea Ahmed in Journal of Cardiovascular Translational Research
    Article 12 July 2024

  19. Protective defunctioning stoma in bowel segmental resection at the time of total hysterectomy for endometriosis: when less is more

    Purpose

    To compare postoperative complications in women undergoing total hysterectomy with segmental resection (TH-SR) for intestinal endometriosis...

    Carolina Dolci, Yohan Kerbage, ... Chrystèle Rubod in Archives of Gynecology and Obstetrics
    Article Open access 12 July 2024

  20. Gut Microbiota in Primary Osteoporosis: a Systematic Review

    The link between gut microbiota (GM) and primary osteoporosis has garnered substantial attention. In this study, we conducted a systematic review...

    Jiangxun Ji, Feihong Cai, ... Yongjun Wang in Phenomics
    Article Open access 12 July 2024
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