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Development and validation of extraction and clean-up procedures for UPLC-MS/MS analysis of aflatoxins in spices
UPLC-MS/MS analytical conditions for the analysis of aflatoxins in spices were optimized and validated in this study. Liquid-liquid partition-based...
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Silencing DOCK2 Attenuates Cardiac Fibrosis Following Myocardial Infarction in Mice Via Targeting PI3K/Akt and Wnt/β-Catenin Pathways
Cardiac fibrosis following myocardial infarction (MI) seriously affects the prognosis and survival rate of patients. This study aimed to determine...
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Exploring barriers and solutions to consumer involvement in health service research using a nominal group technique
BackgroundConsumer involvement in health research is when patients, their families and caregivers work with researchers on research projects. Despite...
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Biological Evaluation of Lysionotin: a Novel Inhibitor of 5-Lipoxygenase for Anti-glioma
ObjectiveTo explore the potential mechanism of lysionotin in treating glioma.
MethodsFirst, target prediction based on Bernoulli Naïve Bayes...
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Electroacupuncture Alleviates Memory Deficits in APP/PS1 Mice by Targeting Serotonergic Neurons in Dorsal Raphe Nucleus
ObjectiveAlzheimer’s disease (AD) has become a significant global concern, but effective drugs able to slow down AD progression is still lacked....
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The relationship between Stroma AReactive Invasion Front Areas (SARIFA), Warburg-subtype and survival: results from a large prospective series of colorectal cancer patients
BackgroundStroma AReactive Invasion Front Areas (SARIFA) is a recently identified haematoxylin & eosin (H&E)based histopathologic biomarker in...
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Dietary patterns and hepatocellular carcinoma risk: a systematic review and meta-analysis of cohort and case–control studies
BackgroundGlobally, HCC presents a significant health burden, characterized by high incidence and mortality rates. Epidemiological studies have...
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Sedentary behavior is associated with the mental health of university students during the Covid-19 pandemic, and not practicing physical activity accentuates its adverse effects: cross-sectional study
BackgroundMovement behaviours, such as sedentary behavior (SB) and physical inactivity, have become a public health issue due to their implications...
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An initial user model design for adaptive interface development in learning management system based on cognitive load
The cognitive aspect is crucial in develo** interactive and adaptive systems, including learning management systems (LMS). By understanding human...
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Impact of baseline body composition on prognostic outcomes in urological malignancies treated with immunotherapy: a pooled analysis of 10 retrospective studies
ObjectiveNumerous epidemiological investigations have explored the impact of body composition on the effectiveness of immune checkpoint inhibitors...
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Decomposing the gaps in healthy and unhealthy life expectancies between Indigenous and non-Indigenous Australians: a burden of disease and injury study
BackgroundThe gaps in healthy life expectancy (HLE) between Indigenous and non-Indigenous Australians are significant. Detailed and accurate...
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African American Female Veterans Experiences with Perceived Racism Within the Veteran’s Healthcare Administration
There is a lack of understanding of how perceived racism in Veterans Healthcare Administration (VHA) healthcare providers affects the delivery of...
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A new approach to prevent radiation-induced xerostomia using intraglandular injection of mitochondria-boosting agents
Radiotherapy in patients with head and neck cancer fairly leads to xerostomia, profoundly affecting their quality of life. With limited effective...
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The ANGPTL4-HIF-1α loop: a critical regulator of renal interstitial fibrosis
BackgroundRenal interstitial fibrosis (RIF) is a progressive, irreversible terminal kidney disease with a poor prognosis and high mortality....
