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Effects of Sex Steroids on Innate and Adaptive Immunity
Estrogens and androgens are classically recognized as reproductive sex steroid hormones because of their well-documented effects on reproductive... -
Methylprednisolone Modulates the Tfr/Tfh ratio in EAE-Induced Neuroinflammation through the PI3K/AKT/FoxO1 and PI3K/AKT/mTOR Signalling Pathways
Methylprednisolone (MP) is a potent glucocorticoid that can effectively inhibit immune system inflammation and brain tissue damage in Multiple...
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Efficacy of tibial cortex transverse transport in treating diabetic foot ulcer and its effect on serum omentin-1 and irisin levels
ObjectiveDiabetic foot ulcer (DFU) is a common and debilitating complication of diabetes that is associated with an increased risk of lower-limb...
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Association between carpal height ratio and ulnar variance in normal wrist radiography
IntroductionThe wrist joint is a complex anatomical structure, and various radiographic parameters are utilized to assess its normal alignment and...
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CYP24A1 Deficiency Mimicking Other Causes of Hypercalciuria and Nephrocalcinosis: A Case Report
In this report, we discuss the case of a 54-year-old patient attending our department with osteopenia, urolithiasis, significant hypercalciuria, and...
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Emodin alleviates intestinal ischemia–reperfusion injury through antioxidant stress, anti-inflammatory responses and anti-apoptosis effects via Akt-mediated HO-1 upregulation
BackgroundIntestinal ischemia–reperfusion (I/R) injury is a severe vascular emergency. Previous research indicated the protective effects of Emodin...
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The association between the neutrophil-to-lymphocyte ratio and type 2 diabetes mellitus: a cross-sectional study
BackgroundType 2 diabetes mellitus (T2DM) is a prevalent chronic disease often accompanied by low-grade inflammation. Recently, the...
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Schmerztherapie in der Rheumatologie
Treatment of painful rheumatic diseases encompasses nonpharmacologic and pharmacologic measures. Pain of short duration usually responds well to...
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The incidence of fractures in children under two years of age: a systematic review
BackgroundEpidemiological research on fractures in children under the age of two is of great importance to help understand differences between...
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Effect of changes in motor skill induced by educational video program to decrease lower-limb joint load during cutting maneuvers: based on musculoskeletal modeling
BackgroundThis study investigated the effects of changes in motor skills from an educational video program on the kinematic and kinetic variables of...
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New studies with stable gastric pentadecapeptide protecting gastrointestinal tract. significance of counteraction of vascular and multiorgan failure of occlusion/occlusion-like syndrome in cytoprotection/organoprotection
Since the early 1990s, when Robert’s and Szabo’s cytoprotection concept had already been more than one decade old, but still not implemented in...
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Experimental study on the biomechanical stability of complex acetabular fractures in the quadrilateral area: application of a dynamic anterior titanium-plate screw system
Background and objectiveComplex acetabular fractures involving quadrilateral areas are more challenging to treat during surgery. To date, there has...
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Operative treatment of isolated epiphyseal fracture of the distal fibula: 1 case report and literature review
Pediatric ankle injuries are common; ankle epiphyseal fractures are also common in children. But isolated distal epiphyseal fibular fractures of the...
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Protective effects of ginsenosides on ulcerative colitis: a meta-analysis and systematic review to reveal the mechanisms of action
BackgroundUlcerative colitis (UC) is a chronic inflammatory disease of the colon. Ginsenoside may be an ideal agent for UC treatment. However, its...
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Comparative effects of different treatments based on the levonorgestrel intrauterine system in endometrial carcinoma and endometrial hyperplasia patients: a network meta-analysis
ObjectiveLevonorgestrel intrauterine system (LNG-IUS) has been widely used in patients with endometrial carcinoma (EC), endometrial hyperplasia...
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INFLA score: a novel inflammatory marker for assessing cardiometabolic disease risk in obese individuals
BackgroundThe low-grade inflammation score (INFLA-score) is a composite index that assesses chronic inflammatory status using multiple inflammatory...
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Challenges in the management of patients with HNF1B MODY and multisystem manifestations: the cases of two adolescent boys
IntroductionHepatocyte nuclear factor-1 beta ( HNF1B ) encodes a homeodomain-containing transcription factor, which is expressed early in...
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Effect of switching from twice-daily basal insulin to once-daily insulin glargine 300 U/mL (Gla-300) in Brazilian people with type 1 diabetes
BackgroundLow adherence to the number of insulin injections and glycemic variability are among the challenges of insulin therapy in type 1 diabetes...