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The Impact of Lebrikizumab on Vaccine-Induced Immune Responses: Results from a Phase 3 Study in Adult Patients with Moderate-to-Severe Atopic Dermatitis
IntroductionLebrikizumab, a high-affinity IgG4 monoclonal antibody that selectively inhibits interleukin-13 with high binding affinity and slow...
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COPD, PRISm and lung function reduction affect the brain cortical structure: a Mendelian randomization study
Chronic obstructive pulmonary disease (COPD) has been associated with alterations in the brain cortical structure. Nonetheless, the causality between...
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LINE1-mediated epigenetic repression of androgen receptor transcription causes androgen insensitivity syndrome
Androgen insensitivity syndrome (AIS) is a difference of sex development (DSD) characterized by different degrees of undervirilization in individuals...
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Fabrication, characterization and numerical validation of a novel thin-wall hydrogel vessel model for cardiovascular research based on a patient-specific stenotic carotid artery bifurcation
In vitro vascular models, primarily made of silicone, have been utilized for decades for studying hemodynamics and supporting the development of...
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Association between the serum uric acid/serum creatinine ratio and cognitive function in older adults: NHANES in the United States
Cognitive impairment can potentially become a significant health concern in older adults. However, early effective diagnostic methods are still...
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Generalized Simulation-Based Domain Adaptation Approach for Intelligent Bearing Fault Diagnosis
In recent years, various deep learning techniques have been utilized for dealing with bearing fault diagnosis. Although these methods have achieved...
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Single-cell transcriptomics analysis of bullous pemphigoid unveils immune-stromal crosstalk in type 2 inflammatory disease
Bullous pemphigoid (BP) is a type 2 inflammation- and immunity-driven skin disease, yet a comprehensive understanding of the immune landscape,...
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Mechanical power density, spontaneous breathing indexes, and prolonged weaning failure: a prospective cohort study
A prospective observational study comparing mechanical power density (MP normalized to dynamic compliance) with traditional spontaneous breathing...
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Insights into bioactive constituents of onion (Allium cepa L.) waste: a comparative metabolomics study enhanced by chemometric tools
BackgroundOnion waste was reported to be a valuable source of bioactive constituents with potential health-promoting benefits. This sparked a surge...
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Therapeutic potential of Buddleja Polystachya Fresen (stem and leaves) extracts: antimicrobial and cytotoxic properties for ocular disease management
This study on Buddleja polystachya highlights its phytochemical composition, antimicrobial activity, and cytotoxic impacts. The study emphasizes the...
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Structural, elastic, electronic, optical and anisotropy properties of newly quaternary Tl2HgGeSe4 via DFPT predictions associated to XPES and RS experiments
In the present work, we report on theoretical studies of thermodynamic properties, structural and dynamic stabilities, dependence of unit-cell...
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Inhomogeneous terminators on the exoplanet WASP-39 b
Transmission spectroscopy has been a workhorse technique over the past two decades to constrain the physical and chemical properties of exoplanet...
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Absence of effects of widespread badger culling on tuberculosis in cattle
Government policy in England aims for the elimination of bovine tuberculosis (bTB). This policy includes culling of European badger ( Meles meles ) to...
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\(\text{Sech}^{2}\)-type solitary waves and the stability analysis for the KdV–mKdV equation
In this article, we investigated the solitary wave solutions of the KdV–mKdV equation using Hirota’s bilinear method. Closed-form analytical single...
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The regulatory mechanism of m6A modification in gastric cancer
To the best of our knowledge, N6-Methyladenosine (m6A) exerts a significant role in the occurrence and development of various tumors. Gastric cancer...
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Phylogeography and genetic structure of Papaver bracteatum populations in Iran based on genoty**-by-sequencing (GBS)
Papaver bracteatum , known for its high thebaine content and absence of morphine, has emerged as a promising alternative to opium poppy for codeine...
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Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging
Intrinsic and extrinsic factors, including lifestyle and sun exposure, can contribute to cell senescence, which impairs skin homeostasis, that may in...
