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Development of Technetium-99m and Rhenium-188 Radiopharmaceuticals Containing a Terminal Metal–Nitrido Multiple Bond for Diagnosis and Therapy
The chemistry of nitrido complexes of technetium has played an important role in the search of new Tc-99m radiopharmaceuticals and in providing... -
Monitoring Multidrug Resistance P-Glycoprotein Drug Transport Activity with Single-Photon Emission Computed Tomography and Positron Emission Tomography Radiopharmaceuticals
Multidrug resistance (MDR) mediated by overexpression of MDR1 P-glycoprotein (Pgp) is one of the best characterized transporter-mediated barriers to... -
Rhenium and Technetium Complexes Anchored by Phosphines and Scorpionates for Radiopharmaceutical Applications
This review presents a comprehensive overview of the most significant developments in the chemistry of technetium and rhenium complexes anchored by... -
Radiopharmaceuticals for Positron Emission Tomography Imaging of Somatostatin Receptor Positive Tumors
The targeting of somatostatin receptors in tumors has been a goal in cancer treatment and diagnosis since the 1980s. Over the past two decades, great... -
6-Hydrazinonicotinamide Derivatives as Bifunctional Coupling Agents for 99mTc-Labeling of Small Biomolecules
99mTc-labeled small biomolecules are a class of receptor-based, target specific radiopharmaceuticals for the detection of various diseases, such as... -
Radiolabeled Integrin αvβ3 Antagonists as Radiopharmaceuticals for Tumor Radiotherapy
Integrins are a family of proteins that facilitate cellular adhesion to and migration on the extracellular matrix proteins found in intercellular... -
New Organometallic Technetium Complexes for Radiopharmaceutical Imaging
It is the objective of this review to introduce the reader to the current status of organometallic chemistry, oriented towards the development of... -
Radiomics combined with clinical and MRI features may provide preoperative evaluation of suboptimal debulking surgery for serous ovarian carcinoma
PurposeTo develop and validate a model for predicting suboptimal debulking surgery (SDS) of serous ovarian carcinoma (SOC) using radiomics method,...
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A position-enhanced sequential feature encoding model for lung infections and lymphoma classification on CT images
PurposeDifferentiating pulmonary lymphoma from lung infections using CT images is challenging. Existing deep neural network-based lung CT...
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Prediction of microvascular invasion in hepatocellular carcinoma patients with MRI radiomics based on susceptibility weighted imaging and T2-weighted imaging
BackgroundThe accurate identification of microvascular invasion (MVI) in patients with hepatocellular carcinoma (HCC) is of great clinical importance.
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Needle tracking in low-resolution ultrasound volumes using deep learning
PurposeClinical needle insertion into tissue, commonly assisted by 2D ultrasound imaging for real-time navigation, faces the challenge of precise...
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Impact and effect of imaging referral guidelines on patients and radiology services: a systematic review
ObjectivesThe objective of this systematic review was to offer a comprehensive overview and explore the associated outcomes from imaging referral...
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Signal drift in diffusion MRI of the brain: effects on intravoxel incoherent motion parameter estimates
ObjectivesSignal drift has been put forward as one of the fundamental confounding factors in diffusion MRI (dMRI) of the brain. This study...
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A scarce combination of arterial variants: an occipital artery originating from the internal carotid artery associated with a linguofacial trunk
The occipital artery (OA) typically originates from the external carotid artery (ECA). Variations of the ECA has been well described in the current...
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Microstructural characterization of multiple sclerosis lesion phenotypes using multiparametric longitudinal analysis
Background and objectivesIn multiple sclerosis (MS), slowly expanding lesions were shown to be associated with worse disability and prognosis. Their...
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Detection of pulmonary nodules in chest radiographs: novel cost function for effective network training with purely synthesized datasets
PurposeMany large radiographic datasets of lung nodules are available, but the small and hard-to-detect nodules are rarely validated by computed...
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Patients with complex and very-early-onset ATL1-related spastic paraplegia offer insights on genotype/phenotype correlations and support for autosomal recessive forms of SPG3A
Spastic paraplegia type 3A (SPG3A) is the second most common form of hereditary spastic paraplegia (HSP). This autosomal-dominant-inherited motor...
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An evaluation of morphometry and dehiscence of facial canal: a systematic review and meta-analysis of observational studies
IntroductionThe facial canal (FC) is an extensive bony canal that houses the facial nerve and occupies a central position in the petrous part of...