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The human Werner Syndrome as a model system for aging
The aging process is one of the most challenging biological pathways to understand. Applications of model systems for aging have contributed...
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Aging and mitochondrial dysfunction in the filamentous fungus Podospora anserina
In the filamentous fungus Podospora anserina, mitochondria play a paramount role in life span control and aging. During aging, these organelles...
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Aging and the programmed death phenomena
Biochemical mechanisms of the programmed death phenomena are considered at levels of unicellular organisms, mitochondria, cells, groups of cells, and...
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Energy metabolism, anti-oxidant defense and aging in Caenorhabditis elegans
Food restriction and impaired gene function by mutation or RNAi treatment can extend the lifespan of Caenorhabditis elegans considerably. In contrast...
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Do green plants age, and if so, how?
Time-dependent ageing-like processes in green plants are discussed and compared to gerontological changes in animals and other organisms. The...
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Conditional senescence in prokaryotes
Bacteria are immortal in the sense that their capacity for reproduction appears limitless as long as the environment supports growth. However, this...
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Yeast as a model for ageing and apoptosis research
Apoptosis is a form of programmed cell death with a crucial role in health and disease in metazoans. Recent findings demonstrate the existence of an...
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Mammalian and bird aging, oxygen radicals, and restricted feeding
In this chapter, the relationship of aging with oxidative stress is reviewed. Endogenous tissue antioxidants do not determine aging because they...
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Role of subcytotoxic stress in tissue ageing
Most commonly stress-induced premature senescence (SIPS) is defined as the long-term effects of subcytotoxic stress on proliferative cell types,...
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Mitochondria, metabolism, and aging in yeast
Quantitative and qualitative changes in metabolism take place when the lifespan is extended in yeast either by genetic or nutritional manipulation....
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Prophylactic Effect and Antiulcerogenic Potential of Probiotic Lactiplantibacillus plantarum E1K2R2 and its Exopolysaccharide Against Ibuprofen-Induced Acute Gastric Ulcer
Lactiplantibacillus plantarum ( Lpb. plantarum ), as a safe probiotic microorganism, has been documented for its production of multiple bioactive...
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Naturalized alien flora of Uzbekistan: species richness, origin and habitats
This is the first study providing an up-to-date account of the alien flora in Uzbekistan and analyzing the relationship between the invasion status...
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The autophagy adaptor TRIAD3A promotes tau fibrillation by nested phase separation
Multiple neurodegenerative diseases are characterized by aberrant proteinaceous accumulations of tau. Here, we report a RING-in-between-RING-type E3...
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Zeb1 mediates EMT/plasticity-associated ferroptosis sensitivity in cancer cells by regulating lipogenic enzyme expression and phospholipid composition
Therapy resistance and metastasis, the most fatal steps in cancer, are often triggered by a (partial) activation of the epithelial–mesenchymal...
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Exploring the cooperation between nitrogen-fixing and non-fixing alfalfa rhizobia
Alfalfa plays a crucial role in agriculture due to its nitrogen-fixing partnership with rhizobia, resulting in nutritious forage. While the potential...
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Diagnostic applicability of mitogenomics in uncovering intraspecific carangid diversifications: insights into phylogeny, divergence time, and characterization of two cryptic Selaroides leptolepis mitogenomes
Carangidae is an economically important fish family comprised of 32 genera with more than 140 circumglobally distributed species. Its members exhibit...
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Restructuring of Skull Modularity Pattern in Evolution Within Myotis myotis–Myotis blythii Species Group (Vespertilionidae, Chiroptera, Mammalia)
Studies of differences in modularity and integration among the related species can provide important information on their evolution. We argue that...
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Changes in benthic communities in Blagopoluchiya Bay (Novaya Zemlya, Kara Sea): the influence of the snow crab
Until recently, the Kara Sea was a stable ecosystem unaffected by alien species invasions. However, at the beginning of the twenty-first century, the...
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Computational Insights into Papaveroline as an In Silico Drug Candidate for Alzheimer’s Disease via Fyn Tyrosine Kinase Inhibition
Alzheimer’s disease (AD) poses a significant global health challenge, necessitating the exploration of novel therapeutic strategies. Fyn Tyrosine...
