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  1. SHR-A1811 (antibody-drug conjugate) in advanced HER2-mutant non-small cell lung cancer: a multicenter, open-label, phase 1/2 study

    A dose-escalation and expansion, phase 1/2 study (ClinicalTrials.gov, NCT04818333) was conducted to assess the novel antibody-drug conjugate...

    Ziming Li, Zhengbo Song, ... Shun Lu in Signal Transduction and Targeted Therapy
    Article Open access 15 July 2024

  3. Environmental Oxidative Stress – Environmental Sources of ROS

    Environmental factors are known sources for oxidative stress. In consequence of the numerous influences that define our environment, environmental...
    Peter Schröder, Jean Krutmann in Reactions, Processes
    Chapter

  4. Endogenous Oxidant-Generating Systems

    Although organisms respiring air oxygen use their energy sources in an optimal way they are threatened by the compulsory formation of reactive oxygen...
    Hans Nohl, Andrey V. Kozlov, ... Katrin Staniek in Reactions, Processes
    Chapter

  5. Low Molecular Weight Antioxidants

    Low molecular weight antioxidants are an important part of the antioxidative defense mechanisms of cells and organisms. This chapter gives a short...
    Tilman Grune, Peter Schröder, Hans K. Biesalski in Reactions, Processes
    Chapter

  6. Modulation of Cellular Signaling Processes by Reactive Oxygen Species

    Exposure of cells to reactive oxygen species (ROS) may result not only in cell death by excessive oxidation of biomolecules but also cause the...
    Lars-Oliver Klotz in Reactions, Processes
    Chapter

  7. Development of Technetium-99m and Rhenium-188 Radiopharmaceuticals Containing a Terminal Metal–Nitrido Multiple Bond for Diagnosis and Therapy

    The chemistry of nitrido complexes of technetium has played an important role in the search of new Tc-99m radiopharmaceuticals and in providing...
    Alessandro Boschi, Adriano Duatti, Licia Uccelli in Contrast Agents III
    Chapter

  8. Glutathione

    Glutathione is the most abundant non-protein thiol in cells. It is a tripeptide with two important structural features: the thiol group and the...
    Juan Sastre, Federico V. Pallardo, Jose Viña in Reactions, Processes
    Chapter

  9. Monitoring Multidrug Resistance P-Glycoprotein Drug Transport Activity with Single-Photon Emission Computed Tomography and Positron Emission Tomography Radiopharmaceuticals

    Multidrug resistance (MDR) mediated by overexpression of MDR1 P-glycoprotein (Pgp) is one of the best characterized transporter-mediated barriers to...
    Vijay Sharma, David Piwnica-Worms in Contrast Agents III
    Chapter

  10. The Broad Spectrum of Responses to Oxidative Stress in Proliferating Cells

    Proliferating mammalian cells exhibit a broad spectrum of responses to oxidative stress, depending on the stress level encountered. Very low levels...
    Kelvin J. A. Davies in Reactions, Processes
    Chapter

  11. Alendronate treatment rescues the effects of compressive loading of TMJ in osteogenesis imperfecta mice

    Background

    Osteogenesis imperfecta (OI) is a genetic disorder of connective tissue caused by mutations associated with type I collagen, which results...

    Po-Jung Chen, Shivam Mehta, ... Sumit Yadav in Progress in Orthodontics
    Article Open access 15 July 2024

  13. Chemical Modifications of Biomolecules by Oxidants

    There is strong evidence in support of the oxidation of biomolecules during normal physiology and under conditions of environmental or pathological...
    Helen R. Griffiths in Reactions, Processes
    Chapter

  14. Rhenium and Technetium Complexes Anchored by Phosphines and Scorpionates for Radiopharmaceutical Applications

    This review presents a comprehensive overview of the most significant developments in the chemistry of technetium and rhenium complexes anchored by...
    Isabel Santos, António Paulo, João D. G. Correia in Contrast Agents III
    Chapter

  15. Radiopharmaceuticals for Positron Emission Tomography Imaging of Somatostatin Receptor Positive Tumors

    The targeting of somatostatin receptors in tumors has been a goal in cancer treatment and diagnosis since the 1980s. Over the past two decades, great...
    Wen ** Li, Laura A. Meyer, Carolyn J. Anderson in Contrast Agents III
    Chapter

  16. FDG altered biodistribution in white adipose tissue, a rare entity: case report and review of the literature

    Purpose

    Altered 18 F-fluorodeoxyglucose (FDG) biodistribution due to patient factors such as exercise and inadequate fasting are well established...

    William Y. Raynor, Stephen J. Sozio, Jeffrey S. Kempf in EJNMMI Reports
    Article Open access 15 July 2024

  17. Deep transfer learning for detection of breast arterial calcifications on mammograms: a comparative study

    Introduction

    Breast arterial calcifications (BAC) are common incidental findings on routine mammograms, which have been suggested as a sex-specific...

    Nazanin Mobini, Davide Capra, ... Francesco Sardanelli in European Radiology Experimental
    Article Open access 15 July 2024

  18. Superoxide Dismutases and Catalase

    Superoxide dismutases (SODs) and catalase represent the primary enzymatic defense against reactive oxygen species. Both enzymes are present in...
    Grzegorz Bartosz in Reactions, Processes
    Chapter

  19. 6-Hydrazinonicotinamide Derivatives as Bifunctional Coupling Agents for 99mTc-Labeling of Small Biomolecules

    99mTc-labeled small biomolecules are a class of receptor-based, target specific radiopharmaceuticals for the detection of various diseases, such as...
    Shuang Liu in Contrast Agents III
    Chapter

  20. Protein Repair and Degradation

    Protein oxidation is one of the important processes taking place during oxidative stress. Numerous amino acids can be modified within proteins...
    Diana Poppek, Tilman Grune in Reactions, Processes
    Chapter
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