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Comprehensive analysis of transcription factors involved in odontoblast differentiation mechanism
Primary cultured odontoblasts rapidly lose their tissue-specific phenotype. To identify transcription factors (TF) that are important for the...
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Gut microbiota-derived metabolites tune host homeostasis fate
The gut microbiota, housing trillions of microorganisms within the gastrointestinal tract, has emerged as a critical regulator of host health and...
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Intracellular galectin interactions in health and disease
In the galectin family, a group of lectins is united by their evolutionarily conserved carbohydrate recognition domains. These polypeptides play a...
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The role of microglia in early neurodevelopment and the effects of maternal immune activation
Activation of the maternal immune system during gestation has been associated with an increased risk for neurodevelopmental disorders in the...
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Immunohistochemistry staining of Eag1 and p16/Ki-67 can help improve the management of patients with cervical intraepithelial Neoplasia after cold knife conversion
BackgroundImmunohistochemistry (IHC) is widely used in the management of patients with cervical intraepithelial neoplasia (CIN) but still has many...
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The Increase of Soluble Urokinase Plasminogen Activator Receptor in Heart Failure is Related to Disease Severity and Cardiac Mortality
Heart failure (HF) is a life-threatening syndrome with high prevalence and mortality rates. Soluble urokinase plasminogen activator receptor (suPAR)...
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Quantifizierung von Ki-67 in PitNET („pituitary neuroendocrine tumors“)/Adenomen
This study is the first to compare the determination of the Ki-67 index in pituitary neuroendocrine tumors (PitNET)/pituitary adenomas by...
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Stability of new psychoactive substances in crude wastewater
Those involved in drug testing continue to grapple with the dynamic nature of emerging psychoactive substances (NPS) and their rapid infiltration...
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Hepatitis B virus in Egypt: the whole story
Hepatitis B virus (HBV) infection is a significant global public health threat with variable geographical distribution. Chronic infection with HBV...
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Influence of Suppressor of Cytokine Signaling 1 (SOCS1) Gene Variations on Polycystic Ovary Syndrome
Polycystic ovarian syndrome (PCOS) is associated with low-grade systemic inflammation and an increase in inflammation markers, which are crucial in...
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Dynamic ultrasound assessment for insertional achilles tendinopathy: the COcco-RIcci (CORI) sign
ObjectiveTo describe a novel, dynamic ultrasound assessment of the Achilles tendon at the calcaneal insertion taking advantage of the effusion within...
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Small molecule inhibitors of the VEGF and tyrosine kinase for the treatment of cervical cancer
Cervical cancer accounts for most deaths due to cancer in women, majorly in develo** nations. The culprit behind this disease is the human...
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Situs inversus partialis (levocardia): an incidental discovery of an extremely rare case during the autopsy of a female with suicidal poisoning
BackgroundSitus inversus is a rare congenital anomaly. In this condition, the abdominal and chest organs are positioned in reverse, a mirror image of...
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Prevalence of hepatitis B among pregnant women in Libreville, Gabon
BackgroundHepatitis B virus (HBV) infection is one of the major public health problems worldwide. In pregnant women, there is a risk of...
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Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases
Proteolytic cell surface release (‘shedding’) of the prion protein (PrP), a broadly expressed GPI-anchored glycoprotein, by the metalloprotease...
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Hepatic cholera: a case report with literature review
BackgroundVasoactive intestinal peptide-secreting tumors (VIPomas), also known as WDHA syndrome (or “pancreatic cholera”), are rare neuroendocrine...
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Microsecretory adenocarcinoma of the hard palate: a case report and literature review
Microsecretory adenocarcinoma (MSA) is a new type of salivary gland neoplasm identified in the 2022 World Health Organization Classification of Head...
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Fluorescence confocal microscopy for evaluation of fresh surgical specimens and consecutive tumor cell isolation in rare pediatric tumors
Fluorescence confocal microscopy (FCM) is an optical technique that uses laser light sources of different wavelengths to generate real-time images of...
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Methylprednisolone Modulates the Tfr/Tfh ratio in EAE-Induced Neuroinflammation through the PI3K/AKT/FoxO1 and PI3K/AKT/mTOR Signalling Pathways
Methylprednisolone (MP) is a potent glucocorticoid that can effectively inhibit immune system inflammation and brain tissue damage in Multiple...
