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Systems Biology: necessary developments and trends
At the end of this definition of Systems Biology through exampling, we discuss ambitions, goals, and challenges relating to this new discipline. We...
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Scientific and technical challenges for systems biology
Systems biology is an emergent discipline, yet can be rooted back almost a century when pioneering thoughts on system-oriented views were discussed....
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From isolation to integration, a systems biology approach for building the Silicon Cell
In the last decade, the field now commonly referred to as systems biology has developed rapidly. With the sequencing of whole genomes and the...
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Systems biology of apoptosis
New approaches are required for the mathematical modelling and system identification of complex signal transduction networks, which are characterized...
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Current Status of Computerized Decision Support Systems in Mammography
Breast cancer is one of the most devastating and deadly diseases for women today. Despite advances in cancer treatment, early mammographic detection...
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Analysis and Architecture of Clinical Workflow Systems using Agent-Oriented Lifecycle Models
Healthcare executives are grappling with a climate of great change in the healthcare industry. This is coming from a number of sources. First, there...
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Modelling signalling pathways – a yeast approach
MAP kinase pathways are conserved signalling systems in eukaryotes that control stress responses, cell growth, and proliferation, as well as...
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Metabolic flux analysis: A key methodology for systems biology of metabolism
Genome-wide analyses of mRNA, protein, or metabolite complements of biological systems produce unprecedented data sets. In contrast to such cellular...
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Mechanistic and modular approaches to modeling and inference of cellular regulatory networks
In this chapter we wish to present a vision of systems biology as a discipline that generates new insight and knowledge with quantitative and...
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Mathematical modelling of the Wnt-pathway
A kinetic model of the Wnt-signal transduction pathway is presented which includes the main molecular components of this system. It is based on a set...
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Systems Biology: Did we know it all along?
It is often suggested that Systems Biology is nothing new, or that it is irrelevant. Its central paradigm, i.e. that much of biological function...
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Systems biology of the yeast cell cycle engine
One goal of systems biology is to obtain an integrated understanding of the physiological properties of cells from the detailed molecular machinery...
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A modular systems biology analysis of cell cycle entrance into S-phase
A modular systems biology approach to the study of the cell cycle of the budding yeast Saccharomyces cerevisiae is presented. Literature on the...
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What is systems biology? From genes to function and back
The essence of the grand contributions of physiology and molecular biology to biology is discussed in relation to what may be needed to understand...
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Modeling the E. coli cell: The need for computing, cooperation, and consortia
Escherichia coli K-12 is an ideal test bed for pushing forward the limits of our ability to understand cellular systems through computational...
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Computerization of Clinical Guidelines: an Application of Medical Document Processing
Clinical Guidelines are being developed as a tool to promote Best Practice in Medicine. They are usually defined as “systematically developed...
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Case-based Medical Informatics
The “applied” nature distinguishes applied sciences from theoretical sciences. To emphasize this distinction, we begin with a general, meta-level...
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Medical Diagnosis and Prognosis Based on the DNA Microarray Technology
Immense genomic data have been accumulated through various research activities such as the Human Genome Project. A genome is the entire collection of...
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Wearable Devices in Healthcare
The miniaturization of electrical and electronic equipment is certainly not a new phenomenon, and its effects have long been evident in the...
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Evidence Based Telemedicine
This chapter focuses on evidence based telemedicine and its various applications. Evidence based medicine is the integration of best research...