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Strategies for modeling aging and age-related diseases
The ability to reprogram patient-derived-somatic cells to IPSCs (Induced Pluripotent Stem Cells) has led to a better understanding of aging and...
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Simultaneous de novo calling and phasing of genetic variants at chromosome-scale using NanoStrand-seq
The successful accomplishment of the first telomere-to-telomere human genome assembly, T2T-CHM13, marked a milestone in achieving completeness of the...
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Pig blastocyst-like structure models from embryonic stem cells
Pluripotent stem cells have the potential to generate embryo models that can recapitulate developmental processes in vitro. Large animals such as...
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Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis
The initiation of osteogenesis primarily occurs as mesenchymal stem cells undergo differentiation into osteoblasts. This differentiation process...
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A pan-KRAS degrader for the treatment of KRAS-mutant cancers
KRAS mutations are highly prevalent in a wide range of lethal cancers, and these mutant forms of KRAS play a crucial role in driving cancer...
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Cytotoxic effects of the cigarette smoke extract of heated tobacco products on human oral squamous cell carcinoma: the role of reactive oxygen species and CaMKK2
BackgroundThe increasing prevalence of heated tobacco products (HTPs) has heightened concerns regarding their potential health risks. Previous...
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Structural and functional insights into the helicase protein E5 of Mpox virus
Mpox virus (MPXV) can cause mpox in humans. Due to its quick and wide spread in the past two years, mpox has turned into a significant public health...
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Nodal degree centrality in the default mode-like network of the TgF344-AD Alzheimer’s disease rat model as a measure of early network alterations
This study investigates brain network alterations in the default mode-like network (DMLN) at early stages of disease progression in a rat model of...
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Transcriptome analysis of cynomolgus macaques throughout their lifespan reveals age-related immune patterns
Despite the different perspectives by diverse research sectors spanning several decades, aging research remains uncharted territory for human beings....
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Increased vascular smooth muscle cell senescence in aneurysmal Fibulin-4 mutant mice
Aortic aneurysms are dilatations of the aorta that can rupture when left untreated. We used the aneurysmal Fibulin-4 R/R mouse model to further...
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TMC6 functions as a GPCR-like receptor to sense noxious heat via Gαq signaling
Thermosensation is vital for the survival, propagation, and adaption of all organisms, but its mechanism is not fully understood yet. Here, we find...
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Multiscale and multidisciplinary analysis of aging processes in bone
The world population is increasingly aging, deeply affecting our society by challenging our healthcare systems and presenting an economic burden,...
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Physiology of the volume-sensitive/regulatory anion channel VSOR/VRAC: part 2: its activation mechanisms and essential roles in organic signal release
The volume-sensitive outwardly rectifying or volume-regulated anion channel, VSOR/VRAC, which was discovered in 1988, is expressed in most vertebrate...
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Identification of hypothermia-inducing neurons in the preoptic area and activation of them by isoflurane anesthesia and central injection of adenosine
Hibernation and torpor are not passive responses caused by external temperature drops and fasting but are active brain functions that lower body...
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Single-cell sequencing depicts tumor architecture and empowers clinical decision in metastatic conjunctival melanoma
Conjunctival melanoma (CoM) is a potentially devastating tumor that can lead to distant metastasis. Despite various therapeutic strategies for...
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Clathrin mediates membrane fission and budding by constricting membrane pores
Membrane budding, which underlies fundamental processes like endocytosis, intracellular trafficking, and viral infection, is thought to involve...
