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Biogenesis of Rab14-positive endosome buds at Golgi–endosome contacts by the RhoBTB3–SHIP164–Vps26B complex
Early endosomes (EEs) are crucial in cargo sorting within vesicular trafficking. While cargoes destined for degradation are retained in EEs and...
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Negative regulation of thyroid adenoma-associated protein (THADA) in the cardiac glycoside-induced anti-cancer effect
Cardiac glycosides, known as inhibitors of Na + ,K + -ATPase, have anti-cancer effects such as suppression of cancer cell proliferation and induction of...
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Acetate ameliorates ovarian mitochondrial dysfunction in letrozole-induced polycystic ovarian syndrome rat model by improving mitofusin-2
Androgen excess and metabolic abnormality largely contribute to the pathogenesis of polycystic ovarian syndrome (PCOS), which primarily precipitates...
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An interactive simulator to deepen the understanding of Guyton’s venous return curve
Mean circulatory filling pressure, venous return curve, and Guyton’s graphical analysis are basic concepts in cardiovascular physiology. However,...
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Microplastics dampen the self-renewal of hematopoietic stem cells by disrupting the gut microbiota-hypoxanthine-Wnt axis
Microplastics (MPs) are contaminants ubiquitously found in the global biosphere that enter the body through inhalation or ingestion, posing...
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Mycobacterium tuberculosis inhibits METTL14-mediated m6A methylation of Nox2 mRNA and suppresses anti-TB immunity
Internal N 6 -methyladenosine (m 6 A) modifications are among the most abundant modifications of messenger RNA, playing a critical role in diverse...
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Fast and flexible profiling of chromatin accessibility and total RNA expression in single nuclei using Microwell-seq3
Single cell chromatin accessibility profiling and transcriptome sequencing are the most widely used technologies for single-cell genomics. Here, we...
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Brain atrophy in normal older adult links tooth loss and diet changes to future cognitive decline
Several studies have found associations between poor oral health, particularly tooth loss and cognitive decline. However, the specific brain regions...
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RBBP6 maintains glioblastoma stem cells through CPSF3-dependent alternative polyadenylation
Glioblastoma is one of the most lethal malignant cancers, displaying striking intratumor heterogeneity, with glioblastoma stem cells (GSCs)...
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Influence of sex on sympathetic vasomotor outflow responses to passive leg raising in young individuals
The purpose of this study was to clarify sex differences in the inhibition of sympathetic vasomotor outflow which is caused by the loading of...
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Switch of innate to adaptative immune responses in the brain of patients with Alzheimer’s disease correlates with tauopathy progression
Neuroinflammation is a key feature of Alzheimer’s disease (AD). In this work, analysis of single- cell RNA-sequencing (scRNA-seq) data obtained from...
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Influence of age on nicotinic cholinergic regulation of blood flow in rat’s olfactory bulb and neocortex
The olfactory bulb receives cholinergic basal forebrain inputs as does the neocortex. With a focus on nicotinic acetylcholine receptors (nAChRs),...
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Structural insights into human organic cation transporter 1 transport and inhibition
The human organic cation transporter 1 (hOCT1), also known as SLC22A1, is integral to hepatic uptake of structurally diversified endogenous and...
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Alteration of serotonin release response in the central nucleus of the amygdala to noxious and non-noxious mechanical stimulation in a neuropathic pain model rat
Previously, we found that serotonin (5-HT) release in the central nucleus of the amygdala (CeA) of anesthetized rats decreases in response to...
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Multi-modal molecular determinants of clinically relevant osteoporosis subtypes
Due to a rapidly aging global population, osteoporosis and the associated risk of bone fractures have become a wide-spread public health problem....
