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MicroRNA miR-20a-5p targets CYCS to inhibit apoptosis in hepatocellular carcinoma
Hepatocellular carcinoma is a primary liver cancer, characterised by diverse etiology, late diagnoses, and poor prognosis. Hepatocellular carcinoma...
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Distinct functions of wild-type and R273H mutant Δ133p53α differentially regulate glioblastoma aggressiveness and therapy-induced senescence
Despite being mutated in 92% of TP53 mutant cancers, how mutations on p53 isoforms affect their activities remain largely unknown. Therefore,...
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The adhesion-GPCR ADGRF5 fuels breast cancer progression by suppressing the MMP8-mediated antitumorigenic effects
ADGRF5 (GPR116) has been identified as a facilitator of breast cancer cell migration and metastasis, yet the underlying mechanisms remain largely...
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Coronin 2B deficiency induces nucleolar stress and neuronal apoptosis
In eukaryotes, the nucleolus is the critical non-membranous organelle within nuclei that is responsible for ribosomal DNA (rDNA) transcription and...
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A cell line derived from the black soldier fly, Hermetia illucens (Diptera: Stratiomyidae)
Insect cell lines are effective tools used in industry and academia. For example, they are used in screening potential insecticides, in making...
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TRIM26 deficiency enhancing liver regeneration through macrophage polarization and β-catenin pathway activation
Liver regeneration is a complex process involving the crosstalk between parenchymal and non-parenchymal cells, especially macrophages. However, the...
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Epigenetic roles of KDM3B and KDM3C in tumorigenesis and their therapeutic implications
Advances in functional studies on epigenetic regulators have disclosed the vital roles played by diverse histone lysine demethylases (KDMs), ranging...
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NOS2-derived low levels of NO drive psoriasis pathogenesis
Psoriasis is an IL-23/Th17-mediated skin disorder with a strong genetic predisposition. The impact of its susceptibility gene nitric oxide synthase 2...
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ASAH1 facilitates TNBC by DUSP5 suppression-driven activation of MAP kinase pathway and represents a therapeutic vulnerability
Triple-negative breast cancer (TNBC) is a subtype of breast cancer that is prone to metastasis and therapy resistance. Owing to its aggressive nature...
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Spatiotemporal distribution of PTEN before directed cell migration in monolayers
The intracellular distribution of phosphatase and tensin homolog (PTEN) is closely related to directed cell migration. In single cells, PTEN...
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TNIP3 protects against pathological cardiac hypertrophy by stabilizing STAT1
Pathological cardiac hypertrophy is one of the major risk factors of heart failure and other cardiovascular diseases. However, the mechanisms...
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Cytotoxic effects of the cigarette smoke extract of heated tobacco products on human oral squamous cell carcinoma: the role of reactive oxygen species and CaMKK2
BackgroundThe increasing prevalence of heated tobacco products (HTPs) has heightened concerns regarding their potential health risks. Previous...
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Structural and functional insights into the helicase protein E5 of Mpox virus
Mpox virus (MPXV) can cause mpox in humans. Due to its quick and wide spread in the past two years, mpox has turned into a significant public health...
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IGFBP2/ITGA5 promotes gefitinib resistance via activating STAT3/CXCL1 axis in non-small cell lung cancer
There is a paucity of comprehensive knowledge pertaining to the underlying mechanisms leading to gefitinib resistance in individuals diagnosed NSCLC...
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Dexmedetomidine improves the circulatory dysfunction of the glymphatic system induced by sevoflurane through the PI3K/AKT/ΔFosB/AQP4 pathway in young mice
Multiple sevoflurane exposures may damage the develo** brain. The neuroprotective function of dexmedetomidine has been widely confirmed in animal...
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Proinflammatory cytokines suppress stemness-related properties and expression of tight junction in canine intestinal organoids
Recent advancements in canine intestinal organoid research have paved the way for the development of enhanced in vitro models, crucial for exploring...
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VHL suppresses UBE3B-mediated breast tumor growth and metastasis
Protein homeostasis is predominantly governed through post-translational modification (PTM). UBE3B, identified as an oncoprotein, exhibits elevated...
