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Conditional senescence in prokaryotes
Bacteria are immortal in the sense that their capacity for reproduction appears limitless as long as the environment supports growth. However, this...
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Do green plants age, and if so, how?
Time-dependent ageing-like processes in green plants are discussed and compared to gerontological changes in animals and other organisms. The...
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Introduction: Lipids: cellular glue...or are they more than that?
Some 40 years ago, there was a rumor in the research community that lipids are the stuff you have to throw away before starting biochemical...
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10 Sphingosine-1-phosphate metabolism in mammalian cell signalling
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite implicated in the regulation of vital biological processes. Ample evidence...
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Energy metabolism, anti-oxidant defense and aging in Caenorhabditis elegans
Food restriction and impaired gene function by mutation or RNAi treatment can extend the lifespan of Caenorhabditis elegans considerably. In contrast...
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Role of NAADP in Coordinating Spatiotemporal Aspects of Calcium Signalling
We outline the roles of two low molecular weight phosphorylated compounds as intracellular messengers in calcium signaling. These new intracellular...
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8 Biosynthesis and compartmentation of triacylglycerol in higher plants
The biosynthesis of storage lipids (triacylglycerols) in higher plants is now known to occur via a number of different routes. These include the...
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Building a Wave – Models of the Puff-to-Wave Transition
Ca2+ release channels open and close randomly because of random binding and dissociation of Ca2+ and IP3 to their subunits. They are arranged in...
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The Endoplasmic Reticulum: A Central Player in Cell Signalling and Protein Synthesis
In addition to being the principle intracellular Ca 2+ store, the endoplasmic reticulum (ER) is the initial site of synthesis and folding of membrane...
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Global and Local Regulation of Neuronal Differentiation by Calcium Transients
Embryonic spinal neurons express ion channels prior to synaptogenesis that mediate specialized forms of excitability promoting Ca 2+ influx. Ca 2+...
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Mitochondrial and ER Calcium Uptake and Release Fluxes and their Interplay in Intact Nerve Cells
Ionized free Ca ( Ca 2+) is a ubiquitous signaling ion that serves as the critical link between a variety of physiological stimuli and their...
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G1 Phase: Components, Conundrums, Context
A eukaryotic cell must coordinate DNA synthesis and chromosomal segregation to generate a faithful replica of itself. These events are confined to...
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The ubiquitin-proteasome pathway in cell cycle control
Ubiquitin-mediated proteolysis is one of the key mechanisms underlying cell cycle control. The removal of barriers posed by accumulation of...
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Mechanistic and modular approaches to modeling and inference of cellular regulatory networks
In this chapter we wish to present a vision of systems biology as a discipline that generates new insight and knowledge with quantitative and...
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Mathematical modelling of the Wnt-pathway
A kinetic model of the Wnt-signal transduction pathway is presented which includes the main molecular components of this system. It is based on a set...
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What is systems biology? From genes to function and back
The essence of the grand contributions of physiology and molecular biology to biology is discussed in relation to what may be needed to understand...
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Systems Biology: Did we know it all along?
It is often suggested that Systems Biology is nothing new, or that it is irrelevant. Its central paradigm, i.e. that much of biological function...
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Modeling the E. coli cell: The need for computing, cooperation, and consortia
Escherichia coli K-12 is an ideal test bed for pushing forward the limits of our ability to understand cellular systems through computational...
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A modular systems biology analysis of cell cycle entrance into S-phase
A modular systems biology approach to the study of the cell cycle of the budding yeast Saccharomyces cerevisiae is presented. Literature on the...
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Regulation of SNARE assembly by protein phosphorylation
Protein phosphorylation is emerging as an important regulatory mechanism that controls the secretory pathway. It enables coupling between the...