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SHR-A1811 (antibody-drug conjugate) in advanced HER2-mutant non-small cell lung cancer: a multicenter, open-label, phase 1/2 study
A dose-escalation and expansion, phase 1/2 study (ClinicalTrials.gov, NCT04818333) was conducted to assess the novel antibody-drug conjugate...
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Redundancy in microbiota-mediated suppression of the soybean cyst nematode
BackgroundSoybean cyst nematodes (SCN) as animal parasites of plants are not usually interested in killing the host but are rather focused on...
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Effect of zeolite and irrigation treatments on grapevine leaves, an interdisciplinary approach
AimsGlobal warming depicts a real challenge for viticulture. As found by PubMed results, a 90% increase in the abiotic stress publications number...
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Targeting oncogene-induced cellular plasticity for tumor therapy
Cellular plasticity, the remarkable adaptability of cancer cells to survive under various stress conditions, is a fundamental hallmark that...
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DAP12 interacts with RER1 and is retained in the secretory pathway before assembly with TREM2
DNAX-activating protein of 12 kDa (DAP12) is a transmembrane adapter protein expressed in lymphoid and myeloid lineage cells. It interacts with...
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Spatiotemporal distribution and density of a falconid at an airport offer insights into management plans
Airports can be attractive places for fauna to find food resources, especially for large birds, which can cause severe collisions with aircraft. At...
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SNCA is a potential therapeutic target for COVID-19 infection in diffuse large B-cell lymphoma patients
Cuprotosis related genes (CRGs) have been proved to be potential therapeutic targets for coronavirus disease 2019 (COVID-19) and cancer, but their...
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Brominated Flame Retardants in the Great Lakes
Brominated flame retardants in the Great Lakes have not been as well studied as many of the polychlorinated pollutants, especially PCBs, but in the...
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Polycyclic Aromatic Hydrocarbons in the Great Lakes
Polycyclic aromatic hydrocarbons (PAHs) are produced during the incomplete combustion of organic material. They can also be produced through...
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Auxin Transport and Recycling of PIN Proteins in Plants
Polar transport of the phytohormone auxin is mediated by plasma-membrane and endosome localized carrier proteins. PIN proteins are the best...
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Environmental Design Considerationsfor Somatic Embryogenesis
In addition to the biomolecular, physiological, and biochemical aspects of somatic embryogenesis, careful design of environmental conditions is...
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Origin, Development and Structure of Somatic Embryosin Selected Bulbous Ornamentals: BAP as Inducer
Somatic embryogenesis in three important ornamentals is discussed in this chapter. Direct somatic embryo development on the explant tissues...
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Differential Gene Expression During Somatic Embryogenesis
Somatic embryogenesis is a complex developmental program in which somatic cells are induced for a commitment towards forming totipotent...
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Embryogenesis in Catharanthus roseus: Roles of Some External Factors in Proliferation, Maturation and Germination of Embryos
Catharanthus roseus is an important medicinal plant that contains two well-known anticancerous alkaloids, vincristine and vinblastine. Cell...
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Screening and Analysis of Pollen Tube Mutations
Although the cytology of the cellular aspects of male gametophytic development has been very well described for several species, molecular...
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Participation of Plant Hormones in Determination and Progression of Somatic Embryogenesis
In vitro culture protocols have been developed for many species, mainly using empirical approaches, to induce somatic embryogenesis from various...
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Pesticides in the Great Lakes
Pesticides have been widely and heavily used in agriculture in the Great Lakes Basin (approximately 93000 tons were used in 1995 alone). Herbicides...
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Polychlorinated Biphenyls in the Great Lakes
This chapter reviews the scientific understanding of the concentrations, trends, and cycling of polychlorinated biphenyls (PCBs) in the Great...