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Chiral Ureas and Thiroureas in Asymmetric Catalysis
After an overview of chiral urea and thiourea synthetic methods, this review describes the main applications of urea and thiourea complexes in...
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Synthesis and Surface Reactivity of Organometallic Nanoparticles
The use of organometallic precursors allows the synthesis in mild conditions of nanoparticles of uniform small size (1–3 nm) and of a clean...
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Palladium-Catalyzed Cross-Coupling Reactions in the Synthesis of Pharmaceuticals
The use of Pd-catalyzed cross-coupling methods for the construction of C-C, C-N, and C-O bonds have increased exponentially over the years. The...
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Chiral-at-Metal Complexes as Asymmetric Catalysts
In general, asymmetric catalysts are based on the combination of a chiral organic ligand and a metal ion. Here we show that future research should...
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Development of Transition Metal-Mediated Cyclopropanation Reactions
A brief discussion of the methods for cyclopropane formation emphasizing organometallic reagents and catalysts is followed by several examples of the...
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The Use of N-Heterocyclic Carbenes as Ligands in Palladium-Mediated Catalysis
Recent developments in the use of N-heterocyclic carbenes (NHC) as ligands in palladium-mediated transformations are described. These versatile...
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Nucleophilic Attack by Palladium Species
Recent researches have revealed that certain allyl-, vinyl-, and arylpalladium intermediates show a nucleophilic nature and react with various...
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Palladium-Catalyzed Annulation of Alkynes
Palladium readily catalyzes the cross-coupling of functionally substituted aryl or vinylic halides and alkynes to afford a wide variety of...
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Palladium-Catalyzed Two- or Three-Component Cyclization of Functionalized Allenes
This review summarizes the Pd-catalyzed cyclization of an allene bearing a nucleophilic functionality with an organic or inorganic halide, and the...
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Analogy between Surface and Molecular Organometallic Chemistry
Homogeneous and heterogeneous catalysis traditionally pertains to different communities, and it is thought that they are directed by different...
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Palladium-Catalyzed Cycloaddition Reactions of Arynes
The transition-metal-catalyzed cyclotrimerization of alkynes has been used extensively in synthesis during the past 25 years. However, until recently...
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Catalytic Processes Involving β-Carbon Elimination
Palladium-catalyzed C–C bond cleavage via β-carbon elimination occurs in various cyclic and acyclic systems. Thus, the reaction can be utilized as...
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Biological Organometallic Chemistry of B12
Vitamin B12, the “antipernicious anemia factor” required for human and animal metabolism, was discovered in the late 1940s. B12-derivatives are...
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Cascade and Sequential Catalytic Transformations Initiated by Ruthenium Catalysts
Ruthenium holds a prominent position among the efficient transition metals involved in catalytic processes. Molecular ruthenium catalysts are able...
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The Virtue of Michael-Type Addition Processes in the Design of Transition Metal-Promoted Cyclizative Cascade Reactions
Cascade reactions involving a transition metal-promoted step and a Michael-type addition process have emerged as a powerful tool to construct...
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Medicinal Properties of Organometallic Compounds
Although organometallic compounds are ubiquitous in nature, synthetic organometallic compounds are generally considered to be toxic or...
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Cascade Reactions Involving Pauson–Khand and Related Processes
The Pauson–Khand [2 + 2 + 1] cycloaddition is one of the best ways to construct a cyclopentenone. It implies the formation of three new bonds and...
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Domino Heck-Pericyclic Reactions
Palladium-catalyzed cross-coupling reactions and cycloadditions as well as electrocyclic transformations can efficiently be combined in one-pot...
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Non-Salen Metal-Catalyzed Asymmetric Dihydroxylation and Asymmetric Aminohydroxylation of Alkenes. Practical Applications and Recent Advances
Over the past two decades the asymmetric dihydroxylation (AD) and asymmetric aminohydroxylation (AA) of alkenes has attracted a great deal of...
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Organometallic Receptors for Biologically Interesting Molecules
Trinuclear organometallic macrocycles are able to complex amino acids and peptides in aqueous solution. The complexation, which is driven by...