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Gene therapy by virus-like self-spooling toroidal DNA condensates for revascularization of hindlimb ischemia
Peripheral arterial diseases (PAD) have been reported to be the leading cause for limb amputations, and the current therapeutic strategies including...
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Engineered plastic-associated bacteria for biodegradation and bioremediation
The global plastic waste crisis has triggered the development of novel methods for removal of recalcitrant polymers from the environment....
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Gene expression modulation tools for bacterial synthetic biology
Synthetic biology has revolutionized the creation of microbial cell factories for the efficient production of value-added chemicals and materials...
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ESF1 and MIPEP proteins promote estrogen receptor-positive breast cancer proliferation and are associated with patient prognosis
BackgroundEstrogen receptor-positive (ER+) breast cancer accounts for two-thirds of all breast cancers, and its early and late recurrences still...
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Examining the determinants of food waste behavior in China at the consumer level
Food loss and waste are global problems for food security, as one-third of all food produced globally does not reach the consumer’s table. These...
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Exploring the challenges of RNAi-based strategies for crop protection
RNA silencing (or RNA interference, RNAi) initiated by double-stranded RNAs is a conserved mechanism for regulating gene expression in eukaryotes....
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Comparison of Molecular Mechanisms of Somatic and Zygotic Embryogenesis
Somatic embryogenesis has been used as a model system to understand the mechanisms regulating plant embryogenesis. The morphological and...
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Importance of Cytoskeleton and Cell Wall in Somatic Embryogenesis
Both the cytoskeleton composed of microtubules and actin microfilaments as well as cell wall components such as arabinogalactan proteins and...
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Gametic Embryogenesis in Triticum: a Study of Some Critical Factors in Haploid (Microspore) Embryogenesis
This review of embryogenesis from microspores in two types of wheat examines the influences of various procedures used to induce and produce...
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Structural features of fungal genomes
Eighteen fungal genomes have been sequenced to date from a variety of taxonomic groups, with fifteen Ascomycota, two Basidomycota and one...
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Comparative genomics and gene finding in fungi
In the spring of 2005, we had access to 18 fully sequenced fungal genomes, and more are coming rapidly. New approaches and methods are being...
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Random Voronoi Ensembles for Gene Selection in DNA Microarray Data
Currently, cancer and other complex pathologies are analyzed mainly by morphological classification. In the past few decades there have been dramatic...
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Cancer Classification with Microarray Data Using Support Vector Machines
Microarrays (Schena et al. 1995) are also called gene chips or DNA chips. On a microarray chip, there are thousands of spots. Each spot contains the...
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Class Prediction with Microarray Datasets
Microarray technology is having a significant impact in the biological and medical sciences and class prediction will play an increasingly important...
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A Dynamic Model of Gene Regulatory Networks Based on Inertia Principle
In molecular biology, functions are produced by a set of macromolecules that interact at different levels. Genes and their products, proteins,...
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Production and Formulation of Adenovirus Vectors
Adenovirus vectors have attracted considerable interest over the past decade, with ongoing clinical development programs for applications ranging...
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Nonviral Delivery of Cancer Genetic Vaccines
The potential use of genetic vaccines to address numerous diseases including cancer is promising, but currently unrealized. Here, we review...
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Genetic Algorithms and Genetic Linkage
This chapter provides a summary of fundamental materials on genetic algorithms. It presents definitions of genetic algorithm terms and briefly...
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Advanced Targeting Strategies for Murine Retroviral and Adeno-associated Viral Vectors
Targeted gene delivery involves broadening viral tropism to infect previously nonpermissive cells, replacing viral tropism to infect a target cell...
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Molecular Conjugates
Molecular conjugates are nanometer-sized entities consisting of synthetic materials (lipids, polycations, targeting agents, and so on) and nucleic...