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Molecular-Scale Studies on Biopolymers Using Atomic Force Microscopy
The atomic force microscope (AFM) is capable of acquiring a range of structural and physicochemical information on a wide range of biopolymers. The...
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Polymer Genomics
Biological activities of biocompatible synthetic polymers used in drug delivery, gene delivery, vaccine development or biomaterial surface...
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Biopolyesters in Tissue Engineering Applications
Tissue engineering is a rapidly growing interdisciplinary field of research focused on the development of vital autologous tissue through the use...
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Interfaces to Control Cell-Biomaterial Adhesive Interactions
Cell adhesion to adsorbed proteins and adhesive sequences engineered on surfaces is crucial to cellular and host responses to implanted devices,...
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Solid-State Structure, Organizationand Properties of Peptide—Synthetic Hybrid Block Copolymers
Peptide–synthetic hybrid block copolymers are most easily prepared via ring-opening polymerization of α-amino acid N-carboxyanhydrides using...
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Domino Dendrimers
Domino dendrimers have recently been developed and introduced as a potential platform for a single triggered multi-prodrug. Surprisingly, three...
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Polymeric Systems for Bioinspired Delivery of Angiogenic Molecules
Growth factors are increasingly utilized to promote regeneration of lost or compromised tissues and organs. However, current strategies applying...
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Synthesis of Bio-Inspired Hybrid PolymersUsing Peptide Synthesis and Protein Engineering
The construction of well-defined hybrid materials consisting of synthetic polymers and (poly)peptides or proteins has attracted much attention in...
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Regeneration of Urologic Tissues and Organs
Patients suffering from a variety of urologic diseases may be treated with transplanted tissues and organs. However, there is a shortage of donor...
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Cyanine Dye–DNA Interactions: Intercalation, Groove Binding, and Aggregation
The cyanine dyes are among the oldest classes of synthetic compounds but continue to find applications in a variety of fields. In many cases, the...
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Radiopharmaceuticals for Positron Emission Tomography Imaging of Somatostatin Receptor Positive Tumors
The targeting of somatostatin receptors in tumors has been a goal in cancer treatment and diagnosis since the 1980s. Over the past two decades, great...
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Palladium-Catalyzed Cycloaddition Reactions of Arynes
The transition-metal-catalyzed cyclotrimerization of alkynes has been used extensively in synthesis during the past 25 years. However, until recently...
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Co-Oligomerization of 1,3-Butadiene and Ethylene Promoted by Zerovalent ‘Bare’ Nickel Complexes
The transition-metal-catalyzed cyclooligomerization of 1,3-dienes and the co-oligomerization of 1,3-dienes and alkenes, that involve the...
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Organolithium in Asymmetric Processes
The development of asymmetric processes has been the focus of industrial research as most of the molecules of pharmaceutical interest contain chiral...
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Rhodium/Ruthenium Applications
Asymmetric catalytic hydrogenation and hydrogen transfer reactions of various substrates such as prochiral ketones and olefins using Rh(I) and Ru(II)...
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Palladium-Catalyzed Cross-Coupling Reactions in the Synthesis of Pharmaceuticals
The use of Pd-catalyzed cross-coupling methods for the construction of C-C, C-N, and C-O bonds have increased exponentially over the years. The...
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Synthesis and Reactivity of Zirconium–Silene Complex
When Cp2ZrCl2 was treated with 2 equivalents of Me2PhSiLi, a zirconium–silene complex was formed. In the presence of alkyne, diarylalkyne reacted...
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Synthesis and Reactivity of Zirconaaziridines
η2-Imine complexes of zirconium, or zirconaaziridines, have attracted attention as amino carbanion equivalents. They can be prepared from an amine...
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Facts and Theories of Induced Organ Regeneration
Induced organ regeneration is de novo synthesis of a physiological, or nearly physiological, organ at the same anatomical site as the organ that is...
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