Search
Search Results
-
Biosynthesis and function of 1-methyladenosine in transfer RNA
Determining the function of single nucleotide modifications in tRNA has been elusive because so many tRNA modification enzymes are not essential for...
-
Transfer RNA modifications and modifying enzymes in Saccharomyces cerevisiae
Transfer RNAs are adaptor molecules, which decode mRNA into protein and, thereby, play a central role in gene expression. During the maturation of a...
-
Systems biology of apoptosis
New approaches are required for the mathematical modelling and system identification of complex signal transduction networks, which are characterized...
-
Total Internal Reflection Fluorescence Microscopy in Single Molecule Nanobioscience
Recent development in total internal reflection fluorescence microscopy (TIRFM) has made it possible to directly monitor the behaviors of...
-
Tracking Movement in Cell Biology
This article is an overview of techniques for measuring movement of proteins, vesicles and cells using digital image processing. Diverse techniques...
-
The biosynthesis and functional roles of methylated nucleosides in eukaryotic mRNA
Modified nucleosides are present in mRNA of all eukaryotes, albeit at much lower levels than in other RNA moieties such as rRNA, tRNA, and snRNA....
-
Adenosine to inosine RNA editing in animal cells
Major advances in the understanding of adenosine deaminases acting on RNA (ADARs) have come from the generation of ADAR mutant animals. In mice,...
-
Scientific and technical challenges for systems biology
Systems biology is an emergent discipline, yet can be rooted back almost a century when pioneering thoughts on system-oriented views were discussed....
-
Fluorescence Lifetime Imaging Microscopy (FLIM)
Fluorescence lifetime imaging microscopy (FLIM) is a technique to map the spatial distribution of nanosecond excited state lifetimes within...
-
Spectral Imaging and Linear Unmixing in Light Microscopy
Fluorescence microscopy is an essential tool for modern biological research. The wide range of available fluorophores and labeling techniques allows...
-
Degradation and Preservation of Organic Matter in Marine Sediments
Organic matter that is deposited in aquatic sediments is subject to an intense diagenetic reactor that determines how much organic carbon is...
-
Systems Biology: necessary developments and trends
At the end of this definition of Systems Biology through exampling, we discuss ambitions, goals, and challenges relating to this new discipline. We...
-
The Material-Independent Signatures of Life.Forensic Tools of Astrobiology
Biological life is intimately related to the geochemical conditions on Earth and is fit for this planet’s energy flux. It has often been suggested...
-
The Early History of Bioenergy
Energy is most commonly defined as the potential to do work. The maintenance of the living state requires a constant flow of energy through the...
-
Assembling the Early Puzzle of Life
So far no theory, no approach, no set of formulas, and no blackboard scheme have been found satisfactory in explaining the origin of life. The...
-
The Early History of Bio-Information
In a general sense, the information level of a structure equals the minimum number of instructions needed to specify the structure (Orgel 1973). The...
-
Higher Harmonic Generation Microscopy
Higher harmonic-generation, including second harmonic generation and third harmonic generation, leaves no energy deposition to the interacted matters...
-
Conserved ribosomal RNA modification and their putative roles in ribosome biogenesis and translation
rRNA maturation requires extensive covalent modifications of riboses and bases. These modifications concern exclusively the most conserved regions of...
-
Biosynthesis and function of tRNA wobble modifications
Post-transcriptional modifications at the first (wobble) position of the tRNA anticodon participate in the precise decoding of the genetic code that...
-
From isolation to integration, a systems biology approach for building the Silicon Cell
In the last decade, the field now commonly referred to as systems biology has developed rapidly. With the sequencing of whole genomes and the...