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PEGylation of Proteins as Tailored Chemistry for Optimized Bioconjugates
The high potential of peptides and proteins as therapeutic agents has not been fully exploited because of their common shortcomings: the only...
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Polymer Therapeutics for Cancer: Current Status and Future Challenges
Drug delivery systems for cancer therapeutics have revolutionized medicine. Delivery systems have improved the efficacy and reduced the toxicity of...
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Enzymatic Polymerization to Polysaccharides
Polysaccharides are formed by repeated glycosylations between a sugar donor and a sugar acceptor. This chapter reviews the in vitro synthesis of...
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Polymer Therapeutics: Polymers as Drugs, Drug and Protein Conjugates and Gene Delivery Systems: Past, Present and Future Opportunities
As the 21st century begins we are witnessing a paradigm shift in medical practice. Whereas the use of polymers in biomedical materials applications...
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Block Copolymer Micelles
This review summarizes recent advances to date in the area of block copolymer micelles and also tries to highlight some new directions in that...
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Surface-Grafted Polymer Gradients: Formation, Characterization, and Applications
This review presents to-date progress in the formation of surface-tethered polymer assemblies with gradually varying physico-chemical properties....
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Computer-Aided Conformation-Dependent Design of Copolymer Sequences
A survey is given of the simulation methods as applied to the design of nontrivial sequences in synthetic copolymers aimed at achieving desired...
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After-Action of the Ideas of I.M. Lifshitz in Polymer and Biopolymer Physics
We review the development of ideas in polymer physics initially formulated by I.M. Lifshitz. We start with general issues in polymer statistics,...
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Role of Physical Factors in the Process of Obtaining Copolymers
A brief introduction into the principles of the statistical description of the chemical structure of linear heteropolymers is given....
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Polypeptide and Polypeptide Hybrid Copolymer Synthesis via NCA Polymerization
This article summarizes recent developments in the synthesis of polypeptides and hybrid peptide copolymers. Traditional methods used to polymerize...
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Nucleation and Crystallization in Diblock and Triblock Copolymers
Crystallization of block copolymer microdomains can have a tremendous influence on the morphology, properties and applications of these materials....
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Gene Delivery Using Polymer Therapeutics
The use of polymers as synthetic non-viral carriers for introducing nucleic acids into cells appears very appealing. Polymers can be generated in...
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Synthesis of Phenol Polymers Using Peroxidases
This chapter deals with the peroxidase-catalyzed polymerization of phenol and its derivatives. Such a polymerization needs an oxidation reagent,...
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Polymer Brushes by Anionic and Cationic Surface-Initiated Polymerization (SIP)
The formation of homopolymer and block copolymer brushes grafted from flat and nanoparticle surfaces via surface-initiated anionic and cationic...
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Solution Properties of Polypeptide-based Copolymers
The aggregation behaviour of biomimetic polypeptide hybrid copolymers and copolypeptides is here reviewed with a particular eye on the occurrence...
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Nanostructured Devices Based on Block Copolymer Assemblies for Drug Delivery: Designing Structures for Enhanced Drug Function
Block copolymers spontaneously assemble into nanoscaled polymeric micelles, which have significant potential as drug carriers. Following much work...
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Surface Rearrangement of Diblock Copolymer Brushes—Stimuli Responsive Films
This article reviews results from our group of the synthesis and characterization of diblock copolymer brushes. Results from the literature are...
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Dynamical Theory of Parametric X-ray Radiation
Previous chapters demonstrate a close analogue between the theory of parametric X-ray radiation (PXR) in thin crystals and the kinematic theory of...
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Cu-Mg-Si (Copper - Magnesium - Silicon)
This document is part of Subvolume A4 'Light Metal Systems. Part 4: Selected Systems from Al-Si-Ti to Ni-Si-Ti' of Volume 11 'Ternary Alloy Systems -...
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Aid of Scaling Laws in the Achievement of a Well-Controlled Film Deposition Process
Scaling laws are profitably applied in all the scientific disciplines. Approximated solutions constitute a valuable aid for the analysis of complex...