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The Use of Drugs that Should be Avoided or Used with Caution in Patients Hospitalized for Acute Decompensated Heart Failure
BackgroundHeart failure (HF) is a pervasive global health concern, with acute decompensated heart failure (ADHF) contributing significantly to...
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The role of playgrounds in promoting children’s health – a sco** review
BackgroundActive outdoor play is important for children’s health and development, and playgrounds provide good places for play. However, the...
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Microglia are dispensable for experience-dependent refinement of mouse visual circuitry
To test the hypothesized crucial role of microglia in the developmental refinement of neural circuitry, we depleted microglia from mice of both sexes...
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Effect of transcranial direct current stimulation with concurrent cognitive performance targeting posterior parietal cortex vs prefrontal cortex on working memory in schizophrenia: a randomized clinical trial
Working memory deficits are linked to irregularities in the dorsolateral prefrontal cortex (DLPFC) and the posterior parietal cortex (PPC) in...
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Improving student diet and food security in higher education using participatory and co-creation approaches: a systematic review
BackgroundHigher education students are an important target group for public health nutrition interventions. When designing tailored and contextually...
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The risks for major psychiatric disorders in the siblings of probands with major depressive disorder
Using a case-controlled study including siblings of major depression (MD) and control probands, born 1970–1990 and followed through 2018, we sought...
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Thalamocortical functional connectivity and rapid antidepressant and antisuicidal effects of low-dose ketamine infusion among patients with treatment-resistant depression
Previous studies have shown an association between the thalamocortical dysconnectivity and treatment-resistant depression (TRD). Whether a single...
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The concept of cognitive readiness: potential solution and opportunity for the Malaysian army
This paper focuses on exploring the potential solution and opportunity in the development of the Malaysian Army Transformation Plan by using the...
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Pharmacotherapy as an Augmentation to Bariatric Surgery for Obesity
A global obesity pandemic is one of the most significant health threats worldwide owing to its close association with numerous comorbidities such as...
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Synchronous citizen science with dogs
Citizen science approaches have grown in popularity over the years, partly due to their ability to reach a wider audience and produce more...
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Uncovering the unique characteristics of different groups of 5-HT5AR ligands with reference to their interaction with the target protein
BackgroundThe serotonin 5-HT 5A receptor has attracted much more research attention, due to the therapeutic potential of its ligands being...
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HIV in Eswatini: Climate Change Impacts and Adaptation Strategies
Purpose of ReviewThis review assessed the impact of climate change on HIV transmission and HIV care of children and adults in Eswatini, and what...
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Dusting Metarhizium rileyi conidia with a drone for controlling fall armyworm and soybean looper in maize and soybean fields
Exploring the utilization of drones for field applications of entomopathogenic fungus as a dry powder marks a pioneering effort in pest management....
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Effects of psychedelic, DOI, on nucleus accumbens dopamine signaling to predictable rewards and cues in rats
Psychedelics produce lasting therapeutic responses in neuropsychiatric diseases suggesting they may disrupt entrenched associations and catalyze...
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Endpoints for Pharmacotherapy Trials for Alcohol Use Disorder
Alcohol use disorder (AUD) is a debilitating disorder, yet currently approved pharmacotherapies to treat AUD are under-utilized. The three...
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Givinostat: First Approval
Givinostat (DUVYZAT™), an orally available histone deacetylase inhibitor, is being developed by Italfarmaco for the treatment of muscular dystrophy...
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Is the Homologous Recombination Repair Mutation Defined by a 15-Gene Panel Associated with the Prognosis of Epithelial Ovarian Cancer?
BackgroundThere is no consensus regarding the specific genes included in the homologous recombination repair (HRR) gene panel for identifying the HRR...
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Nogapendekin alfa Inbakicept: First Approval
Nogapendekin alfa inbakicept (ANKTIVA ® ; nogapendekin alfa inbakicept-pmln) is a recombinant interleukin-15 (IL-15) superagonist protein complex being...
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Empagliflozin Effects in Patients with ST-Elevation Myocardial Infarction Undergoing Primary PCI: The EMI-STEMI Randomized Clinical Trial
IntroductionEmpagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, improves cardiovascular outcomes in heart failure patients, but data...
