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Evaluating the feasibility and acceptability of a co-designed physical activity intervention for rural middle schoolers: a pilot study
BackgroundLack of physical activity is a concern for children across diverse backgrounds, particularly affecting those in rural areas who face...
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TMAO Impairs Mouse Aortic Vasodilation by Inhibiting TRPV4 Channels in Endothelial Cells
Trimethylamine oxide (TMAO) is an intestinal flora metabolite associated with risk of cardiovascular diseases. Transient receptor potential vanilloid...
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Update on the pathophysiology and treatment of primary Sjögren syndrome
Sjögren syndrome or Sjögren disease is a chronic form of autoimmune epithelitis characterized by lymphocytic infiltration of the exocrine glands,...
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Morphological Features of the Vertebrobasilar System Predict Ischemic Stroke Risk in Spontaneous Vertebral Artery Dissection
The vertebral artery’s morphological characteristics are crucial in spontaneous vertebral artery dissection (sVAD). We aimed to investigate...
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Septic Shock, Tubular Necrosis, and Central Diabetes Insipidus: A Challenging Syndrome
BackgroundThe association between septic shock, acute tubular necrosis, and central diabetes insipidus is infrequent: our recent clinical observation...
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Psychological distress mediates the association between COVID-19-related discrimination and subsequent PTSD symptom severity in healthcare workers: a two-year follow-up study
BackgroundPast research has suggested a cross-sectional association between COVID-19-related discrimination and PTSD symptom severity. However, no...
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Serum dysregulation of serine and glycine metabolism as predictive biomarker for cognitive decline in frail elderly subjects
Frailty is a common age-related clinical syndrome characterized by a decline in the function of multiple organ systems, increased vulnerability to...
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Clinical assessment of breastfeeding in preterm infants
Breastmilk confers empirical benefits for preterm infants, however direct breastfeeding rates in this population remain low. For preterm infants, it...
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Bacteriological quality and physicochemical analysis of the Kalte River at Wolaita Sodo Town, southern Ethiopia
ObjectiveThe current research aimed to investigate the physicochemical and bacteriological quality status of the Kalte River in Wolaita Sodo Town,...
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Childhood PFAS exposure and immunotoxicity: a systematic review and meta-analysis of human studies
BackgroundExposure to poly- and perfluoroalkyl substances (PFAS) may affect infant and childhood health through immunosuppression. However, the...
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METTL3-mediated NDUFB5 m6A modification promotes cell migration and mitochondrial respiration to promote the wound healing of diabetic foot ulcer
BackgroundDiabetic foot ulcer (DFU) is the most devastating complication of diabetes mellitus (DM) and plays a major role in disability and death in...
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The accuracy of predicting hospital admission by emergency medical service and emergency department personnel compared to the prehospital MEWS: a prospective multicenter study
IntroductionOvercrowding in the emergency department (ED) is a global problem. Early and accurate recognition of a patient’s disposition could limit...
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Prior emergency medical services utilization is a risk factor for in-hospital death among patients with substance misuse: a retrospective cohort study
BackgroundSubstance misuse poses a significant public health challenge, characterized by premature morbidity and mortality, and heightened healthcare...
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A cross-sectional survey of first-aid kit equipment in a family in Sichuan, China
PurposeTo examine residents’ first-aid kit preparation and its influencing factors.
DesignCross-sectional survey.
MethodsA questionnaire survey was...
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Identification of Parkinson’s disease PACE subtypes and repurposing treatments through integrative analyses of multimodal data
Parkinson’s disease (PD) is a serious neurodegenerative disorder marked by significant clinical and progression heterogeneity. This study aimed at...
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Involvement of Kindlin-1 in cutaneous squamous cell carcinoma
Kindler syndrome (KS) is a rare genodermatosis resulting from loss-of-function mutations in FERMT1 , the gene that encodes Kindlin-1. KS patients have...
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Aqueous shunt exposure repair: outcomes and risk factors for recurrence
ObjectiveTo investigate the outcomes of aqueous shunt exposure repair and to identify risk factors for recurrent exposure after surgical repair.
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